The Application of Supercritical Fluid Extraction in Phenolic Compounds Isolation from Natural Plant Materials

Tyśkiewicz, Katarzyna; Konkol, Marcin; Rój, Edward

doi:10.3390/molecules23102625

Cited by 146 publications

(72 citation statements)

References 165 publications

(299 reference statements)

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“…Despite the fact that several food processing by-products and/or agriculture wastes are being discarded, numerous studies have been demonstrating that they can be an attractive and cheap source of bioactive compounds with high interest for the food, cosmetic, and pharmaceutical industries [6][7][8]. In this way, the use of agro-industry residues to obtain added-value molecules or products is increasingly being suggested as part of the concept of a circular economy [9,10]. Among the molecules/products that can be obtained, phenolic compounds and/or plant extracts rich in these types of compounds have been attracting increasing attention both from researchers and industry.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Phenolic Profile of Castanea sativa Mill. By-Products and Their Antioxidant and Antimicrobial Activity against Multiresistant Bacteria

et al. 2020

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The chestnut industry generates a large amount of by-products. These agro-industrial wastes have been described as potential sources of phenolic compounds with high bioactive potential. Therefore, we aimed to extract the phenolic compounds from chestnut by-products and assess their antioxidant potential and evaluate their antimicrobial activity against multidrug resistant bacteria. The individual phenolic compounds in the ethanolic extracts of chestnut shell, inner shell, bur, and leaves were characterized by HPLC-DAD/electrospray ionization (ESI)-MS. The antioxidant properties were determined by DPPH and ABTS assays. The minimum inhibitory concentration (MIC) and the antimicrobial susceptibility was performed using the Kirby–Bauer disc diffusion method against 10 bacterial strains. The major phenolic compounds identified in the extracts were trigalloyl-HHDP-glucose, gallic acid, quercetin, and myricetin glycoside derivatives. All chestnut by-products presented promising antioxidant activity in both assays, with leaf samples the ones presenting the highest antioxidant capacity. The inner shell’s extract was effective against all Gram-positive and two Gram-negative bacteria; nevertheless, all extracts showed antibacterial activity. Staphylococcus epidermidis showed susceptibility to all extracts while none of the extracts was able to suppress the growth of Escherichia coli and Salmonella enteritidis. Chestnut by-products are a source of phenolic compounds with prominent antioxidant and antimicrobial activities. Nevertheless, further studies should be conducted to assess the correlation between phenolic compounds and the bioactivities obtained.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Phenolic Profile of Castanea sativa Mill. By-Products and Their Antioxidant and Antimicrobial Activity against Multiresistant Bacteria

et al. 2020

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“…However, these methods present low extraction yields with this class of compounds. 13,14 Several novel techniques have been developed to improve the extraction results, including ultrasound-assisted extraction (UAE), 15 microwave-assisted extraction, 15 accelerated solvent extraction, 16 supercritical fluid extraction, 17 and enzymatic extraction. 18 UAE has been widely used to extract phenolic compounds because its cost is relatively low.…”

Section: Introductionmentioning

confidence: 99%

Application of response surface methodology for optimization of ultrasound‐assisted solid‐liquid extraction of phenolic compounds from Cenostigma macrophyllum

Moreira

Filho

Carvalho

et al. 2020

Journal of Chemometrics

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This study determines the optimal conditions for the ultrasound-assisted solidliquid extraction (UA-SLE) of the total phenolic compounds (TPC) of Cenostigma macrophyllum leaves. The experiments were carried out according to three-level, four-variable Box-Behnken design combined with the response surface methodology (RSM). Extraction (sonication) time, liquid-solid ratio, methanol concentration, and ultrasonic power were investigated as independent variables to obtain the optimal extraction conditions for TPC. Data were fitted to a second-order polynomial model, and the model fitness was evaluated by the analysis of variance, which indicated the model (P < 0.0001), presenting precision and reliability with the experiments performed (R 2 = 0.9947, coefficient of variance [CV] = 4.29, SD = 1.67). Individual and interactive effects of the independent variables on TPC extraction were interpreted using the proposed mathematical model. The results showed that for the maximum TPC extraction, the optimal conditions included 32 min extraction time, 29.73 mLÁg −1 liquid-solid ratio, 47.72% methanol concentration, and 145.71 W ultrasonic power. Under these optimal conditions, the predicted values were in agreement with the experimental values, thus validating the RSM model. When the optimal conditions were compared with those of conventional extraction techniques, the results showed that UA-SLE presented significantly better results for TPC extraction (71.2% to 138.3% more efficient) and for antioxidant activity (115.0% to 179.2% more efficient). High-performance liquid chromatography analysis of the extracts revealed that UA-SLE did not interfere with the extract chemical composition, thus confirming that it was more effective than conventional techniques.

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“…By controlling different temperatures, pressures and different kinds and contents of entrainers, the supercritical fluid can selectively extract the components of different polarities, boiling points, and molecular weights successively. This method is called the supercritical fluid extraction (SFE) method [7].…”

Section: Supercritical Fluid Extraction Methodsmentioning

confidence: 99%

Analytical Methods of Isolation and Identification

Feng¹,

Li²,

Hao³

et al. 2020

Phytochemicals in Human Health

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The chemical constituents of plants are complicated, and monomeric compounds must be obtained via extraction and isolation before structure identification, bioactivity screening, and so on. In recent years, the new technologies and methods of the extraction, isolation, and structural identification have come forth, which promote the speed of extraction and analysis of phytochemicals. The chemical structures of compounds from plants must be identified or elucidated, which may provide the necessary basis for further study on the bioactivities, structureactivity relationships, metabolisms in vivo, structural modification, and synthesis of the active compounds. The amount of chemical constituents isolated from plants is often minor, so the structural studies are often difficult to carry out with classical methods. Therefore, spectral analysis is mainly used. This chapter describes the isolation and identification methods during the study of phytochemicals.

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The Application of Supercritical Fluid Extraction in Phenolic Compounds Isolation from Natural Plant Materials

Cited by 146 publications

References 165 publications

Evaluation of the Phenolic Profile of Castanea sativa Mill. By-Products and Their Antioxidant and Antimicrobial Activity against Multiresistant Bacteria

Evaluation of the Phenolic Profile of Castanea sativa Mill. By-Products and Their Antioxidant and Antimicrobial Activity against Multiresistant Bacteria

Application of response surface methodology for optimization of ultrasound‐assisted solid‐liquid extraction of phenolic compounds from Cenostigma macrophyllum

Analytical Methods of Isolation and Identification

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