The Applications of 3D Printing for Craniofacial Tissue Engineering

Tao, Owen; Kort-Mascort, Jacqueline; Lin, Yi Chun; Pham, Hieu M.; Charbonneau, André M.; Elkashty, Osama A.; Kinsella, Joseph M.; Tran, Simon D.

doi:10.3390/mi10070480

Cited by 80 publications

(69 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, scaffold environments that are conducive to differentiation and neotissue growth often require low modulus materials . Other examples of high moduli tissues include periodontal tissue engineering where 3D printing is being investigated . Applications such as skin, skeletal muscle, and blood vessels require high strength and elastic materials to recapitulate the tissues mechanical response in vivo, but these environments may not be optimal for promoting the desired cellular response .…”

Section: Resultsmentioning

confidence: 99%

Stereolithographic 3D Printing for Deterministic Control over Integration in Dual‐Material Composites

Muralidharan

Uzcategui

McLeod

et al. 2019

Adv Materials Technologies

View full text Add to dashboard Cite

A rapid and facile approach to predictably control integration between two materials with divergent properties is introduced. Programmed integration between photopolymerizable soft and stiff hydrogels is investigated due to their promise in applications such as tissue engineering where heterogeneous properties are often desired. The spatial control afforded by grayscale 3D printing is leveraged to define regions at the interface that permit diffusive transport of a second material in‐filled into the 3D printed part. The printing parameters (i.e., effective exposure dose) for the resin are correlated directly to mesh size to achieve controlled diffusion. Applying this information to grayscale exposures leads to a range of distances over which integration is achieved with high fidelity. A prescribed finite distance of integration between soft and stiff hydrogels leads to a 33% increase in strain to failure under tensile testing and eliminates failure at the interface. The feasibility of this approach is demonstrated in a layer‐by‐layer 3D printed part fabricated by stereolithography, which is subsequently infilled with a soft hydrogel containing osteoblastic cells. In summary, this approach holds promise for applications where integration of multiple materials and living cells is needed by allowing precise control over integration and reducing mechanical failure at contrasting material interfaces.

show abstract

Section: Resultsmentioning

confidence: 99%

Stereolithographic 3D Printing for Deterministic Control over Integration in Dual‐Material Composites

Muralidharan

Uzcategui

McLeod

et al. 2019

Adv Materials Technologies

View full text Add to dashboard Cite

show abstract

“…The types of 3D medical printing technology include SLA (Wang, Goyanes, et al, 2016) FDM (Kollamaram et al, 2018), SLS (Beaulieu et al, 2019; Grillo et al, 2018; Huotilainen, Salmi, & Lindahl, 2019; Tao et al, 2019), direct ink writing (DIW) (Xu, Quinn, Lebel, Therriault, & L'Esperance, 2019), ink‐jet printing (Gunasekera et al, 2016), and so forth. Based on the above mature materials and processes, 3D medical printing technology has the advantages of personalized customization, high efficiency, high accuracy, and replicable complex structure. SLA (Wang, Goyanes, et al, 2016) uses a laser with specific intensity and wavelength to focus on the surface of the light‐curing material so that the material is solidified from point to line and then to surface to complete the printing of one layer.…”

Section: Overview Of 3d Printing Technologiesmentioning

confidence: 99%

Three‐dimensional printing: The potential technology widely used in medical fields

Fan

Zhu

2020

J Biomedical Materials Res

View full text Add to dashboard Cite

Three‐dimensional (3D) printing technology is one of the hottest research fields nowadays, which has influenced the treatment methods in the medical industry. In order to explore the progress of 3D printing technology in medical applications, the authors conducted English retrieval with the keywords “three‐dimensionalprinting,” “bioprinting,” and “3D printing” in PubMed, and extracted information related to this exploration. This review firstly introduces the 3D printing materials, types of technology, and printing procedures in medical fields, then elaborates the current applications of 3D printing in medical devices, in vitro anatomical models, organ printing, implants, tissue engineering scaffolds, and the leap from 3D medical printing to four‐dimensional (4D) medical printing, finally put forward the shortage of the medical 3D/4D printing and possible solutions of them.

show abstract

“…То есть дают возможность получения персонализированных конструкций [19]. Подобный подход в настоящее время разрабатывается в стоматологии и челюстно-лицевой хирургии [20,21]. Однако наиболее распространенным подходом, описываемым в данных работах, является печать самого скаффолда, а не формы для него [22].…”

Section: рис 3 пролиферативная активность клеток выращиваемых в фиunclassified

Fibrin scaffolds containing dental pulp stem cells for the repair of periodontal bone defects

Домбровская

Енукашвили

Kotova

et al. 2020

Transl. med. (Print)

View full text Add to dashboard Cite

Background. 3D scaffolds plays an important role in developing new approaches in modern dentistry. They are used to establish optimal conditions for cell differentiation, vascularization and remodeling of regenerating bone tissue.Objective. Evaluation of the possibility of creating scaffolds developed on the basis of 3D modeling of periodontal bone defects and containing tooth pulp stem cells.Materials and Methods. The computer tomography data of the maxillar bone tissue defect were analysed. Anatomical prototype — a mold representing defects of the vestibular and palatal fragments of bone tissue was created by 3D printing. This 3D form was filled with fibrin glue and dental pulp stem cells. The fibrin glue was prepared from autologous blood plasma and mixed with dental pulp stem cells.Results. Fibrin glue prepared from an autologous plasma concentrate (fibrinogen 20 g/l) retains its shape for 4 days. On the day 5, the clot retraction became clearly visible and on the day 7, the clot diameter decreased to 50 % of the original size. The proliferation rate of cells, grown both inside the scaffold and in 2D conditions, did not differ. The immunophenotype of cells of both groups corresponded to the immunophenotype of mesenchy mal stromal cells. The mesenchymal immunophenotype is a feature of dental stem cells. Alizarin red staining of cells both grown on adhesive culture plastic and extracted from glue on day 10 after the induction of osteogenic differentiation did not differ.Conclusion. The fibrin glue is a good material for creation a scaffold with suitable mechanical characteristics. The cells enclosed in the fibrin glue maintain their viability, immunophenotype and osteogenic potential. This technology can be used for bone tissue repair in dentistry and maxillofacial surgery.

show abstract

The Applications of 3D Printing for Craniofacial Tissue Engineering

Cited by 80 publications

References 94 publications

Stereolithographic 3D Printing for Deterministic Control over Integration in Dual‐Material Composites

Stereolithographic 3D Printing for Deterministic Control over Integration in Dual‐Material Composites

Three‐dimensional printing: The potential technology widely used in medical fields

Fibrin scaffolds containing dental pulp stem cells for the repair of periodontal bone defects

Contact Info

Product

Resources

About