The Applications of Gold Nanoparticle-Initialed Chemiluminescence in Biomedical Detection

Abstract

Chemiluminescence technique as a novel detection method has gained much attention in recent years owning to the merits of high sensitivity, wider linear ranges, and low background signal. Similarly, nanotechnology especially for gold nanoparticles has emerged as detection tools due to their unique physical and chemical properties. Recently, it has become increasingly popular to couple gold nanoparticles with chemiluminescence technique in biological agents’ detection. In this review, we describe the superiority of both chemiluminescence and gold nanoparticles and conclude the different applications of gold nanoparticle-initialed chemiluminescence in biomedical detection.

“Green” Synthesis of Metallic Nanoparticles by Sonoelectrochemical and Sonogalvanic Replacement Methods

“… The unique attributes of AuNPs reproduced from [ 7 ] under the terms of the creative commons CC BY license. …”

“…Metal nanoparticles are widely used in biomedicine [ 1 – 5 ], biosensors [ 4 , 6 , 7 ], catalysis [ 1 , 8 ], and other fields. The nanoparticles of noble metals are the most studied in terms of the synthesis methods, as well as physicochemical and functional properties.…”

“…Thus, in [ 6 ], the advantages of plasmonic AgNPs, AuNPs, and PtNPs for the colorimetric sensing applications in drugs assays in pharmaceutical and biological samples are described. The use of gold nanoparticles in the chemiluminescence technique showed a high sensitivity for the detection of biological agents [ 7 ].…”

“…Functional properties of MNPs, especially their biological activity, depend on both the nature of the metal and the geometry of the particles, that is, shape (sphere, rod, nanoshell, nanostar, etc.) and size (from 1 to 100–150 nm) [ 1 – 7 ]. The geometry of MNPs determines their excellent biocompatibility and optical (caused by the surface plasmon resonance phenomenon) and catalytic properties ( Figure 2 ).…”

Gold Nanostar Colorimetric Detection of Fructosyl Valine as a Potential Future Point of Care Biosensor Candidate for Glycated Haemoglobin Detection

“…Their easy synthesis method and their unique physical properties is what makes gold nanoparticles useful. This allows for manipulation and design [21]. Functional gold nanoparticles have been successfully used in protein, enzyme, oligonucleotide, metal ions and small molecule detection and can act as both the molecular acceptor as well as the signal transducer enhancing the sensitivity of a sensor [22,23].…”