2011
DOI: 10.1016/j.tox.2011.07.006
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The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation

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Cited by 71 publications
(34 citation statements)
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“…For concurrent exposures to benzene and toluene, the levels of phenol, cresol and hippuric acid in urine, the inhibition of erythrocyte 59 Fe uptake and the clastogenic effect of benzene were reduced as compared to those for exposures to benzene-only at similar concentrations (Snyder et al 1989;Barale et al 1990). Mogel et al (2011) observed that exposures to aromatic hydrocarbons influence the expression of cyclooxygenase-2 and enhanced the formation of prostaglandin E(2) and prostaglandin F(2 alpha) in human lung epithelial cells.…”
Section: Introductionmentioning
confidence: 98%
“…For concurrent exposures to benzene and toluene, the levels of phenol, cresol and hippuric acid in urine, the inhibition of erythrocyte 59 Fe uptake and the clastogenic effect of benzene were reduced as compared to those for exposures to benzene-only at similar concentrations (Snyder et al 1989;Barale et al 1990). Mogel et al (2011) observed that exposures to aromatic hydrocarbons influence the expression of cyclooxygenase-2 and enhanced the formation of prostaglandin E(2) and prostaglandin F(2 alpha) in human lung epithelial cells.…”
Section: Introductionmentioning
confidence: 98%
“…1,2 The VOCs found in this cigarette smoke have been attributed to diseases of the respiratory (e.g., benzene, toluene, styrene) 3 and cardiovascular system (e.g., benzene, toluene, xylenes, ethylbenzene, styrene), 4 and have been identified as neurological and developmental toxicants (e.g., toluene). 5 For some of these VOCs (i.e., toluene and benzene), cigarette smoke is the primary source of non-occupational exposure in the U.S. population.…”
Section: Introductionmentioning
confidence: 99%
“…Several biological models could explain how organic solvents affect susceptibility to MS, such as altering the impermeability of the blood-brain barrier (Kim et al 2011). Accumulating evidence also suggests that chronic exposure to organic solvents can induce oxidative stress-mediated inflammatory responses (Feltens et al 2010;Mögel et al 2011). Furthermore, organic solvents, such as trichloroethene, induce lipid peroxidation which is implicated in the pathogenesis of various autoimmune diseases.…”
Section: Exposure To Organic Solventsmentioning
confidence: 99%