2015
DOI: 10.1124/pr.114.009001
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The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology

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Cited by 427 publications
(441 citation statements)
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References 239 publications
(313 reference statements)
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“…Results from a variety of laboratories over the past decade have revealed that the AHR has key roles in the development of cardiovascular, reproductive, and neural systems as well as in hematopoiesis and regulation of immune responses (Benedict, Lin, Loeffler, Peterson, & Flaws, 2000; Esser & Rannug, 2015; Gasiewicz, Singh, & Bennett, 2014; Kimura, Ding, & Tohyama, 2016; Lahvis et al., 2005; Quintana & Sherr, 2013; Singh et al., 2014; Stockinger, Di Meglio, Gialitakis, & Duarte, 2014). Some of these functions may involve natural or endogenous ligands such as metabolites generated by the microbiome, tryptophan metabolites, or lipid‐derived molecules (Bessede et al., 2014; Hubbard, Murray, & Perdew, 2015; McMillan & Bradfield, 2007; Moura‐Alves et al., 2014).…”
Section: Ahr Pathwaymentioning
confidence: 99%
“…Results from a variety of laboratories over the past decade have revealed that the AHR has key roles in the development of cardiovascular, reproductive, and neural systems as well as in hematopoiesis and regulation of immune responses (Benedict, Lin, Loeffler, Peterson, & Flaws, 2000; Esser & Rannug, 2015; Gasiewicz, Singh, & Bennett, 2014; Kimura, Ding, & Tohyama, 2016; Lahvis et al., 2005; Quintana & Sherr, 2013; Singh et al., 2014; Stockinger, Di Meglio, Gialitakis, & Duarte, 2014). Some of these functions may involve natural or endogenous ligands such as metabolites generated by the microbiome, tryptophan metabolites, or lipid‐derived molecules (Bessede et al., 2014; Hubbard, Murray, & Perdew, 2015; McMillan & Bradfield, 2007; Moura‐Alves et al., 2014).…”
Section: Ahr Pathwaymentioning
confidence: 99%
“…The stratum corneum also impedes the skin penetration of topical drugs. [46][47][48] A good topical delivery system can enhance the skin penetration of drugs and active ingredients. Paudel et al 49 revealed that the output value of topical and transdermal drug delivery systems will reach 32 billion in the US market in 2015, including polymeric nanoparticles, solid lipid nanoparticles, liposomes, and nanoemulsions.…”
Section: Discussionmentioning
confidence: 99%
“…Extrinsic factors likely to be involved in mediating changes in the CD4 ϩ T-cell response to infection include changes in other immune cells, including dendritic cells, and altered signals from cells of the lung. All of these cells express the AHR and can be modulated by its activation in adult animals (16). The increase in Th1 cells can occur as a result of intrinsic changes in the CD4 lineage, or due to changes in cells extrinsic to the CD4 lineage after developmental AHR activation.…”
Section: Discussionmentioning
confidence: 99%
“…The AHR is an environment-sensing transcription factor in the Per-Arnt-Sim protein superfamily that is broadly expressed in immune and nonimmune cells, including cells of the lung (16). Although endogenous AHR ligands are not fully elucidated, numerous exogenously derived chemicals bind to the AHR.…”
Section: T Cells and May Involve Developmentally Induced Changes In Smentioning
confidence: 99%
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