The assessment of the clinical efficacy and tolerability of complex treatment of patients with acute low-back pain

Dadasheva, M. N.; Горенков, Р. В.; Zolotovskaya, I. A.; Dadasheva, K. N.

doi:10.17116/jnevro202012009147

Cited by 8 publications

(1 citation statement)

References 18 publications

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“…Meloxicam is a preferential COX-2 inhibitor that exhibits COX-2 specificity between 3 and 77 times that of COX-1 [22,23] and is widely used in the veterinary clinic [24][25][26], as well as in humans [27,28]. Meloxicam is widely used as a post-operative treatment to reduce inflammation and pain with very efficient results [29,30].…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective effect of meloxicam in a transient ischemia model involves an increase in axonal sprouting but a decrease in new neuron formation after 7 days of reperfusion

Ugidos

González‐Rodríguez

Santos‐Galdiano

et al. 2021

Preprint

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The inflammatory response plays an important role in neuroprotection and regeneration after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects. In this context, the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stroke, but its ability to inhibit both cyclooxygenase isoforms (1 and 2) could be a promising strategy to modulate post-ischemic inflammation. This study analyzed the effect of the anti-inflammatory agent meloxicam in a transient focal ischemia model in rats, measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area. We show that meloxicam's neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia. Moreover, meloxicam treatment modulated glial scar reactivity, which matched with an increase in axonal sprouting. However, this treatment decreased the formation of neuronal progenitor cells. This study discusses the dual role of anti-inflammatory treatments after stroke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies.

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Section: Introductionmentioning

confidence: 99%

The neuroprotective effect of meloxicam in a transient ischemia model involves an increase in axonal sprouting but a decrease in new neuron formation after 7 days of reperfusion

Ugidos

González‐Rodríguez

Santos‐Galdiano

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Meloxicam

2020

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Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies

Shavlovskaya

Бокова

Shavlovskiy

2021

RJTAO

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More than 500 million people worldwide suffer from osteoarthritis (OA). Neck and low back pain (LBP) is one of the most common reasons for visiting a general practitioner to receive primary medical care in different countries. The prevalence of chronic LBP varies from 4% to 20%, and increases linearly from the third decade to 60 years, and stabilizes in the seventh decade of life. According to the latest published clinical guidelines of the Russian Association for the Study of Pain, nonsteroidal anti-inflammatory drugs (NSAIDs) are used in minimally effective doses and a short course to relieve acute musculoskeletal pain. The ratio of the NSAIDs activity associated with cyclooxygenase (COX) – COX-1 / COX-2 – inhibition allows us to evaluate their potential toxicity. The smaller this value, the more selective the drug is against COX-2, and the less toxic it is. Meloxicam belongs to the predominantly selective COX-2 inhibitors. In the Russian market, meloxicam of domestic production - Amelotex® is widely prescribed. Several studies have shown the high efficacy and safety of meloxicam in the treatment of pain syndromes with different localizations (LBP, neck pain of vertebrogenic nature, OA, etc.), it can be recommended for elderly patients, patients with comorbid diseases such as arterial hypertension (AH), diabetes mellitus, gastrointestinal tract pathology. Meloxicam has a good efficacy and safety profile, a pronounced symptom-modifying effect.

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The assessment of the clinical efficacy and tolerability of complex treatment of patients with acute low-back pain

Cited by 8 publications

References 18 publications

The neuroprotective effect of meloxicam in a transient ischemia model involves an increase in axonal sprouting but a decrease in new neuron formation after 7 days of reperfusion

The neuroprotective effect of meloxicam in a transient ischemia model involves an increase in axonal sprouting but a decrease in new neuron formation after 7 days of reperfusion

Meloxicam

Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies

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