The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without delirium

Kaźmierski, Jakub; Sieruta, Monika; Banyś, Andrzej; Jaszewski, Ryszard; Sobów, Tomasz; Liberski, Paweł P.; Kłoszewska, Iwona

doi:10.1016/j.genhosppsych.2014.06.002

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…Reasons for exclusion were no diagnosis by physician or research personnel (428 studies), no characterization of predisposing or precipitating factors (338 studies), retrospective study design (86 studies), not diagnosed by reference standard (108 studies), no multivariable model (43 studies), delirium assessment not conducted in person (25 studies), not cohort or case-control design (20 studies), sample included less than 50 patients (12 studies), abstract only (18 studies), cohort previously reported (3 studies), and pediatric population (1 studies). Ultimately, 315 studies…”

Section: Resultsmentioning

confidence: 99%

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Predisposing and Precipitating Factors Associated With Delirium

et al. 2023

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ImportanceDespite discrete etiologies leading to delirium, it is treated as a common end point in hospital and in clinical trials, and delirium research may be hampered by the attempt to treat all instances of delirium similarly, leaving delirium management as an unmet need. An individualized approach based on unique patterns of delirium pathophysiology, as reflected in predisposing factors and precipitants, may be necessary, but there exists no accepted method of grouping delirium into distinct etiologic subgroups.ObjectiveTo conduct a systematic review to identify potential predisposing and precipitating factors associated with delirium in adult patients agnostic to setting.Evidence ReviewA literature search was performed of PubMed, Embase, Web of Science, and PsycINFO from database inception to December 2021 using search Medical Subject Headings (MeSH) terms consciousness disorders, confusion, causality, and disease susceptibility, with constraints of cohort or case-control studies. Two reviewers selected studies that met the following criteria for inclusion: published in English, prospective cohort or case-control study, at least 50 participants, delirium assessment in person by a physician or trained research personnel using a reference standard, and results including a multivariable model to identify independent factors associated with delirium.FindingsA total of 315 studies were included with a mean (SD) Newcastle-Ottawa Scale score of 8.3 (0.8) out of 9. Across 101 144 patients (50 006 [50.0%] male and 49 766 [49.1%] female patients) represented (24 015 with delirium), studies reported 33 predisposing and 112 precipitating factors associated with delirium. There was a diversity of factors associated with delirium, with substantial physiological heterogeneity.Conclusions and RelevanceIn this systematic review, a comprehensive list of potential predisposing and precipitating factors associated with delirium was found across all clinical settings. These findings may be used to inform more precise study of delirium’s heterogeneous pathophysiology and treatment.

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Section: Resultsmentioning

confidence: 99%

“…A list of included studies with number of participants and NOS score is included in eTable in Supplement 1). There were 138 studies (43.8%) that excluded participants due to a language barrier (participants were excluded if they did not speak the same language that delirium assessors used).…”

Section: Resultsmentioning

confidence: 99%

Predisposing and Precipitating Factors Associated With Delirium

et al. 2023

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“…Conversely, a meta-analysis of dopaminergic genes (dopamine transporter, SLC6A3, and the D2 dopamine receptor DRD2) identified significant association for a SNP in the former. A SNP in the glutamate receptor GRIN3A was also nominally associated with delirium in a single study (Kazmierski et al, 2014). In the present study, which includes more individuals than in all prior investigations, we did not detect robust evidence of association for any of these candidates (Supplemental Table 2) (Adamis et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association identifies a novel locus for delirium risk

McCoy

Hart

Pellegrini

et al. 2018

Neurobiology of Aging

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We aimed to identify common genetic variations associated with delirium through genome-wide association testing in a hospital biobank. We applied a published electronic health record based definition of delirium to identify cases of delirium, and control individuals with no history of delirium, from a biobank spanning two Boston academic medical centers. Among 6,035 individuals of Northern European ancestry, including 421 with a history of delirium, we used logistic regression to examine genome-wide association. We identified one locus spanning multiple genes, including three interleukin-related genes, associated with p=1.41e-8, and five other independent loci with p<5e-7. Our results do not support previously reported candidate gene associations in delirium. Identifying common-variant associations with delirium may provide insight into the mechanisms responsible for this complex and multifactorial outcome. Using standardized claims-based phenotypes in biobanks should allow the larger-scale investigations required to confirm novel loci such as the one we identify.

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“…Human genetic studies have reported altered prevalence of common and rare GRIN3A variants in schizophrenia patients (Table 2), as well as a linkage peak on chromosome 9 close to the GRIN3A locus in a schizophrenia family study (Greenwood et al 2016), correlated to specific cognitive traits in patients. GRIN3A variants have also been associated with post-operative delirium (Kazmierski et al 2014), a disorder sharing major features with schizophrenia.…”

Section: Schizophreniamentioning

confidence: 99%

“…GRIN3A variants have also been associated with post‐operative delirium (Kazmierski et al . 2014), a disorder sharing major features with schizophrenia.…”

Section: Glun3a/grin3a Disease Linksmentioning

confidence: 99%

GluN3A NMDA receptor subunits: more enigmatic than ever?

Crawley

Conde-Dusman

Pérez‐Otaño

2021

The Journal of Physiology

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Non‐conventional N‐methyl‐d‐aspartate receptors (NMDARs) containing GluN3A subunits have unique biophysical, signalling and localization properties within the NMDAR family, and are typically thought to counterbalance functions of classical NMDARs made up of GluN1/2 subunits. Beyond their recognized roles in synapse refinement during postnatal development, recent evidence is building a wider perspective for GluN3A functions. Here we draw particular attention to the latest developments for this multifaceted and unusual subunit: from finely timed expression patterns that correlate with plasticity windows in developing brains or functional hierarchies in the mature brain to new insight onto presynaptic GluN3A‐NMDARs, excitatory glycine receptors and behavioural impacts, alongside further connections to a range of brain disorders.

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The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without delirium

Cited by 10 publications

References 24 publications

Predisposing and Precipitating Factors Associated With Delirium

Predisposing and Precipitating Factors Associated With Delirium

Genome-wide association identifies a novel locus for delirium risk

GluN3A NMDA receptor subunits: more enigmatic than ever?

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