The association baseline NIH Stroke Scale score with ABO blood-subtypes in young patients with acute ischemic stroke

Yang, Ning; Zhang, Bin; Xie, Longchang; Yin, Jun; He, Yi; Yang, Xiaoshan; Gao, Cong

doi:10.1016/j.atherosclerosis.2014.06.019

Cited by 13 publications

(12 citation statements)

References 29 publications

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“…On this note, the influence of ABO-system blood types on the nervous system has been a largely unexplored research area. Despite the association which has been frequently reported between 'O' and non-'O' blood types and cardiovascular risk factors (Carpeggiani et al, 2010;Wu et al, 2008;Yang et al, 2014), recent findings suggest that other, non-vasculogenic mechanisms might exist, such as, for instance, the involvement of glycosyltransferase enzymes encoded by the ABO genetic locus (Alexander et al, 2014). In a retrospective and explorative fashion, we carried out a voxel-based morphometric analysis of the differences of whole-brain GM volumes between a subgroup of healthy adults with 'O' blood type and comparable subgroups having other blood types.…”

Section: -Discussionmentioning

confidence: 99%

“…Remarkably, an 'O' vs non-'O' difference seems to be visible even at a young age, as ≤ 50 years old sufferers from ischemic stroke carrying both alleles ('AB' blood-type individuals) appear to have a poorer prognosis (Yang et al, 2014). In addition, a recent cohort-based investigation which tested the possibility that 'non-O' adults might show poorer cognitive trajectories, found that 'AB' blood type is associated with higher incidence of cognitive decline (Alexander et al, 2014).…”

Section: -Introductionmentioning

confidence: 99%

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‘O’ blood type is associated with larger grey-matter volumes in the cerebellum

Marco

Venneri

2015

Brain Research Bulletin

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Section: -Discussionmentioning

confidence: 99%

Section: -Introductionmentioning

confidence: 99%

‘O’ blood type is associated with larger grey-matter volumes in the cerebellum

Marco

Venneri

2015

Brain Research Bulletin

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“…In conclusion we believe that, similarly to other scores evaluating the risk of developing acute occlusive arterial events (27,28), the ABO status should be incorporated also in the Cardiorisk score in order to better identify blood donors at higher risk of developing cardiovascular adverse events, and thus implementing preventive measures on modifiable risk factors.…”

Section: Discussionmentioning

confidence: 99%

The relationship between ABO blood group and cardiovascular disease: results from the Cardiorisk program

Capuzzo¹,

Bonfanti²,

Frattini³

et al. 2016

Annals of Translational Medicine

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Background:The ABO blood group exerts a profound influence on hemostasis, and it has hence been associated with the development of thrombotic cardiovascular adverse events. In this study, we evaluated the relationship between the ABO blood group and the risk of cardiovascular disease assessed with the Cardiorisk score.Methods: All blood donors aged between 35 and 65 years were enrolled in the Cardiorisk program, which included the assessment of 8 variables (sex, age, total cholesterol, high-density lipoprotein (HDL) cholesterol, plasma glucose, arterial blood pressure, anti-hypertensive therapy and smoking) which were used to generate a score. Individuals with a resulting score ≥20, considered at high cardiovascular risk, underwent additional instrumental tests (chest X-ray, stress electrocardiogram and Doppler ultrasound of supra-aortic trunks) and were closely clinically monitored.Results: Between January 2005 and December 2015, 289 blood donors with Cardiorisk ≥20 were identified, 249 of whom were included in the study with at least 2 years of follow-up. Among these, 36 (14.5%) had instrumental abnormality tests and developed adverse cardiovascular events (10 acute coronary syndrome, 2 cerebral ischemia, 3 cardiac arrhythmia, 8 stenosis of supra-aortic trunks or iliac arteries) during a median follow-up of 5.3 years. In this group of 249 high risk individuals, a statistically significant association (P=0.02) was found between the non-O blood type and the risk of developing subclinical or clinical cardiovascular events (odds ratio, 3.3; 95% CI, 1.1-10.1; P=0.033). Conclusions:The results of this study underline the both key role of ABO blood group for the risk of developing arterial thrombotic events and the need for including such unmodifiable variable on the scores assessing the thrombotic risk.

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“…Thanks to our research and that of other investigators [55][56][57], the ABO blood type has now been included in a number of scores evaluating the thrombotic risk. For instance, Yang and colleagues assessed the association of blood groups with the National Institute of Health Stroke Scale (NIHSS) score in young stroke patients, and identified the AB subtype as a major predictor of stroke severity [58]. In addition, Gong and colleagues investigated the relation of the ABO blood type and the severity of coronary atherosclerosis assessed by Gensini score, and concluded that blood group A was an independent risk factor (OR 1.44; 95% CI: 1.16-1.80; P = 0.001), whereas group O was a protective factor (OR 0.77; 95% CI: 0.65-0.92; P = 0.004) for serious coronary atherosclerosis [59].…”

Section: Abo and Cardiovascular Diseasementioning

confidence: 99%