The association between alcohol consumption and mortality: the Swedish women’s lifestyle and health study

Behrens, Gundula; Leitzmann, Michael F.; Sandin, Sven; Löf, Marie; Heid, Iris M.; Adami, Hans Olov; Weiderpass, Elisabete

doi:10.1007/s10654-011-9545-x

Cited by 21 publications

(17 citation statements)

References 41 publications

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“…In addition, information on hormone receptor status was available for most of breast cancer patients with relatively high completeness. Another strength is the age structure of the cohort, since few cohort studies aimed to include predominantly premenopausal women [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The details for the calculation of total alcohol intake have been described previously [ 14 ]. Briefly, the reported quantities of beer, wine, and spirits were converted to grams of alcohol using food composition data from the Swedish National Food Administration [ 14 ]. Total alcohol intake was categorized according to the distribution of the variable in the WLH population as categories (0, 0.1–5.0, 5.1–15, and >15 g/day), and as a continuous variable.…”

Section: Methodsmentioning

confidence: 99%

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Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

et al. 2015

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BackgroundWe aimed to estimate the effect of alcohol consumption on breast cancer risk and to test whether overweight and obesity modifies this association.MethodsWe included in the analysis 45,233 women enrolled in the Swedish Women’s Lifestyle and Health study between 1991 and 1992. Participants were followed for occurrence of breast cancer and death until December 2009. Poisson regression models were used, and analyses were done for overall breast cancer and for estrogen receptor positive or negative (ER+, ER-) and progesterone receptor positive and negative (PR+, PR-) tumors separately.ResultsA total of 1,385 breast cancer cases were ascertained during the follow-up period. Overall, we found no statistically significant association between alcohol intake and breast cancer risk after adjustment for confounding, with an estimated relative risk (RR) of 1.01 (95 % CI: 0.98–1.04) for an increment in alcohol consumption of 5 g/day. A statistically significant elevated breast cancer risk associated with higher alcohol consumption was found only among women with BMI ≤25 (RR 1.03, 95 % CI 1.0–1.05 per 5 g/day increase).ConclusionAn increase in breast cancer risk with higher alcohol consumption was found for breast cancers in women with a BMI ≤25 kg/m2.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

et al. 2015

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“…Overall risk of death in middle age was slightly reduced with alcohol intake, although all-cause mortality increased with heavier drinking, particularly among adults under age 60 with a lower risk of cardiovascular disease. 38 Among 87,526 middle-aged female nurses in the Nurses' Health Study, moderate alcohol consumption reduced CHD risk during 334,382 person-years of follow up. An inverse association was demonstrated between alcohol and CHD risk in an analysis of pooled data from eight prospective North American and European studies involving 192,067 women and 74,919 men.…”

Section: Evidence Of Cardiovascular Benefitmentioning

confidence: 99%

Toxic Effects of Alcohol on the Heart

2015

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“…Studies on light-to-moderate alcohol consumption over time and risk of death in women are, however, scarce 10. Within the Swedish Women's Lifestyle and Health (WLH) Study, an earlier analysis showed that a possible beneficial effect of light-to-moderate alcohol drinking was limited to CVD/CHD mortality, with no measurable increase in overall cancer mortality 11. In the current study, we quantify the associations between time-varying alcohol consumption and overall and cause-specific mortality, including cancer mortality—separating ARC and other cancers—death from CVDs, violence and injuries and other causes.…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort

et al. 2016

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BackgroundAlcohol consumption is steadily increasing in high-income countries but the harm and possible net benefits of light-to-moderate drinking remain controversial. We prospectively investigated the association between time-varying alcohol consumption and overall and cause-specific mortality among middle-aged women.MethodsAmong 48 249 women at baseline (33 404 at follow-up) in the prospective Swedish Women's Lifestyle and Health cohort, age 30–49 years at baseline, we used repeated information on alcohol consumption and combined this method with multiple imputation in order to maximise the number of participants and deaths included in the analyses. Multivariable Cox regression models were used to calculate HRs for overall and cause-specific mortality.ResultsDuring >900 000 person/years, a total of 2100 deaths were recorded through Swedish registries. The median alcohol consumption increased from 2.3 g/day in 1991/1992 (baseline) to 4.7 g/day in 2004 (follow-up). Compared with light drinkers (0.1–1.5 g/day), a null association was observed for all categories of alcohol consumption with the exception of never drinkers. The HR comparing never with light drinkers was 1.46 (95% CI 1.22 to 1.74). There was a statistically significant negative trend between increasing alcohol consumption and cardiovascular and ischaemic heart diseases mortality. The results were similar when women with prevalent conditions were excluded.ConclusionsIn conclusion, in a cohort of young women, light alcohol consumption was protective for cardiovascular and ischaemic heart disease mortality but not for cancer and overall mortality.

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The association between alcohol consumption and mortality: the Swedish women’s lifestyle and health study

Cited by 21 publications

References 41 publications

Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

Toxic Effects of Alcohol on the Heart

Alcohol consumption over time and mortality in the Swedish Women’s Lifestyle and Health cohort

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