The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study

Søgaard, Anne‐Johanne; Ranhoff, Anette Hylen; Meyer, Haakon E; Omsland, Tone Kristin; Nystad, Wenche; Tell, Grethe S.; Holvik, Kristin

doi:10.1007/s00198-018-4627-1

Cited by 17 publications

(14 citation statements)

References 40 publications

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“…A number of studies in men had suggested a lower risk with low to moderate intake (13,17,31,36) and this analysis showed an apparent inverse trend even with 30+g/d of consumption, equivalent to over 2 drinks/day. However, a Norwegian study among men over age 60 showed no association up to consumption of 27 servings a week and a suggestion of increased risk above that (35). Therefore, our data agree with others who found low to moderate alcohol intake is not associated with an increased risk but a potential for a lower risk of hip fracture in middle aged and older men.…”

Section: Discussionsupporting

confidence: 86%

“…Existing studies in older women shows that low to moderate alcohol intake were either not associated with or inversely associated with hip fracture risk while high intake trended toward an increased risk (13,(31)(32)(33)(34)(35). In this study, we too observed a reduced risk with low to moderate intakes, equivalent to about 1.5 drinks/day, when compared with abstainers.…”

Section: Discussioncontrasting

confidence: 42%

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Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older

Fung

Mukamal

Rimm

et al. 2019

The American Journal of Clinical Nutrition

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Background Although a number of studies have examined the association between alcohol intake and hip fractures, few have considered specific alcoholic beverages separately. Objectives We prospectively assessed total alcohol and specific alcoholic beverage consumption and risk of hip fractures in US men and women. Methods Health, lifestyle information, and hip fractures were self-reported on biennial questionnaires between 1980 and 2014 in 75,180 postmenopausal women from the Nurses’ Health Study, and between 1986 and 2014 in 38,398 men aged ≥50 y from the Health Professionals Follow-Up Study. Diet was assessed approximately every 4 y with a semiquantitative FFQ. RRs were computed for hip fracture using Cox proportional hazards models, adjusting for potential confounders. Results We ascertained 2360 incident low trauma hip fractures in women and 709 in men. Among women, RRs for low trauma hip fractures compared with nondrinkers were 0.89 (95% CI: 0.80, 0.99) for an average daily consumption of <5.0 g, 0.81 (95% CI: 0.70, 0.94) for 5.0 to <10.0 g, 0.83 (95% CI: 0.71, 0.96) for 10.0 to <20.0 g, and 0.93 (95% CI: 0.78, 1.10) for ≥20.0 g. Among men, risk declined linearly with higher alcohol consumption (P-trend = 0.002). Multivariable RR compared with nondrinkers was 0.77 (95% CI: 0.59, 1.01), 0.69 (0.49, 0.96), and 0.67 (0.48, 0.95) for an average intake of 10 g/d to <20 g/d, 20 g/d to <30 g/d, and 30.0 g/d or more, respectively. In women, the alcoholic beverage most significantly associated with hip fracture risk was red wine (RR per serving = 0.59; 95% CI: 0.45, 0.79). In men, there was no clear association with specific alcoholic beverages. Conclusion In these 2 US cohorts, low to moderate alcohol consumption, when compared with no consumption, was associated with a lower risk of hip fractures, particularly with red wine consumption among women.

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Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 42%

Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older

Fung

Mukamal

Rimm

et al. 2019

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…The number of fracture patients was limited, as the incidence of hip fractures in this age group is low [19]. The sample size was small and included both genders, recognizing the differences in risk factors and epidemiology of hip fracture in women and men [15, 18, 38, 39]. Exact power calculations were not performed, but tripling the number of controls was used to improve statistical strength [26].…”

Section: Discussionmentioning

confidence: 99%

“…We did not record several well-known risk factors for hip fractures and osteoporosis, such as alcohol consumption, calcium and vitamin D levels, differences in bone-associated comorbidities (e.g. malabsorption), hormonal deficits, or the use of specific medication influencing bone quality (steroids, anti-epileptic medication) [20, 34, 35, 39–41].…”

Section: Discussionmentioning

confidence: 99%

Low bone density and high morbidity in patients between 55 and 70 years with displaced femoral neck fractures: a case-control study of 50 patients vs 150 normal controls

Bartels

Gjertsen

Frihagen

et al. 2019

BMC Musculoskelet Disord

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Background A displaced femoral neck fracture (FNF) in patients 55-70 years is a serious injury with a high risk of treatment failure and the optimal surgical treatment remains unclear. We aimed to describe characteristics of fracture patients compared to a sample from the normal population. Methods Fifty patients aged 55-70 years with a displaced FNF were gender- and age- matched with a control group of 150 persons without a hip fracture using computergenerated randomization and the Norwegian National Population Register. To reduce the risk of spurious selection bias, the sample size of the control group was trebled compared to the fracture group. Dual-energy x-ray absorptiometry (DXA) was performed. Demographics and hip function (Harris Hip Score, Oxford Hip Score, and Hip Dysfunction and Osteoarthritis Outcome Score) were collected. Results There were more than 75% women in both groups. The mean age was 64.5 years in the fracture group and 65.1 in the control group. Results for DXA measured for lumbar spine, total hip and the femoral neck showed that patients with displaced FNF were significantly more osteoporotic. Fracture patients had significantly lower body mass index, higher Charlson comorbidity index (CCI), and higher ASA (American Society of Anesthesiologists) score than the control group. No clinically relevant differences in hip function were found. There were 48% smokers in the fracture group compared to 10% in the control group. The odds ratio for obtaining a displaced FNF was high if the patients suffered from osteoporosis, smoked or had several comorbidities. Conclusions This study showed that patients aged 55-70 years with a displaced femoral neck fracture had lower bone density and higher comorbidity compared with a gender- and age-matched population without femoral neck fractures. This suggests that this patient group is epidemiologically similar to older patients with femoral neck fractures.

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“…Despite contradictory association between alcohol intake and incidence of fracture in the elderly, all well sized cohort studies included subjects from various age groups [ 6 , 14 ]. In studies conducted in elderly population only, none of previous researches contained more than 150,000 subjects [ 15 - 17 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Alcohol Intake and Fracture Risk in Elderly Varied by Affected Bones: A Nationwide Longitudinal Study

Wang

Han

Kim

et al. 2020

Psychiatry Investig

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Objective Previous studies investigating association of alcohol intake and fracture risk in elderly yielded conflicting results. We first examined the association between alcohol intake and total fracture risk in elderly subjects and further analyzed whether the association varied by fracture locations.Methods This is a nationwide population-based cohort study which included all people aged 66 (n=1,431,539) receiving the National Screening Program during 2009–2014. Time-to-event were defined as duration from study recruitment, the day they received health screening, to the occurrence of fracture.Results Total fracture was significantly lower in mild drinkers [adjusted hazard ratio (aHR)=0.952; 95% confidence interval (95% CI) =0.931–0.973] and higher in heavy drinkers (aHR=1.246; 95% CI=1.201–1.294) than non-drinkers. Risk pattern of alcohol consumption and fracture differed according to affected bones. Similar J-shaped trends were observed for vertebra fractures, but risk of limb fracture showed a linear relationship with alcohol intake. For hip fracture, risk decrement was more pronounced in mild and moderate drinkers, and significant increment was noted only in very severe drinkers [≥60 g/day; (aHR)=1.446; 1.162–1.801].Conclusion Light to moderate drinking generally lowered risk of fractures, but association between alcohol and fracture risk varied depending on the affected bone lesions.

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The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study

Cited by 17 publications

References 40 publications

Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older

Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older

Low bone density and high morbidity in patients between 55 and 70 years with displaced femoral neck fractures: a case-control study of 50 patients vs 150 normal controls

Association of Alcohol Intake and Fracture Risk in Elderly Varied by Affected Bones: A Nationwide Longitudinal Study

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