The Association Between Apolipoprotein E Genotype and Lipid Profiles in Healthy Woman Workers

Moon, Kieun; Sung, Sook Hee; Chang, Youn Koun; Park, Il Keun; Paek, Yun Mi; Kim, Soo Geun; Choi, Tae In; Jin, Young Woo

doi:10.3961/jpmph.2010.43.3.213

Cited by 14 publications

(4 citation statements)

References 26 publications

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“…Drink consumption is defined as 5 gm or more drinks per day. Insulin resistance (HOMA-IR) was calculated as following formula ( 33 ):…”

Section: Methodsmentioning

confidence: 99%

Association Between Four Anthropometric Indexes and Metabolic Syndrome in US Adults

Zheng

et al. 2022

Front. Endocrinol.

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ObjectiveTo study the association between anthropometric indexes [lipid accumulation products (LAP), visceral obesity index (VAI), triglyceride and glucose index (TyG) and waist triglyceride index (WTI)] and metabolic syndrome (MetS) in a representative sample of American adult population surveyed by National Health and Nutrition Examination Survey (NHANES).MethodsCross-sectional data from the NHANES were used. Participants were adults aged 18–80 y from 1996–2006. MetS were defined by the updated National Cholesterol Education Program/Adult Treatment Panel III criteria (NCEP-ATP III) for Americans. Receiver operating characteristic (ROC) curve was drawn and the areas under the curve (AUC) were used to assess the ability of these indexes in screening MetS. Statistical differences among the AUC values of these indexes were compared. The association between the anthropometric indexes and MetS was investigated using weighted multivariable-adjusted logistic regression.Results560 (35.2%) males and 529 (26.4%) females were diagnosed with MetS. LAP was the strongest predictor of MetS for men (AUC=0.87, 95% CI 0.85-0.89), and also was the strongest for women [AUC=0.85, 95% confidence interval (CI) 0.83-0.86], according to the ROC curve analysis. In men, differences in AUC values between LAP and other anthropometric indicators were also significant (all P<0.001). In women, there was a significant difference in AUC values between LAP and WTI (P<0.001), but differences in AUC values between LAP and TyG, VAI were not significant.ConclusionThe present study indicated that LAP is a better predictor in the clinical setting for identifying individuals with MetS in the American adult population.

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“…Drink consumption is defined as 5 gm or more drinks per day. Insulin resistance (HOMA-IR) was calculated as following formula ( 33 ):…”

Section: Methodsmentioning

confidence: 99%

Association Between Four Anthropometric Indexes and Metabolic Syndrome in US Adults

Zheng

et al. 2022

Front. Endocrinol.

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“…Glycated hemoglobin A1c was measured with high-performance liquid chromatography using Variant II (Bio-Rad, Hercules, CA, USA), and insulin was measured with electrochemiluminescence immunoassay using Roche Modular Analytics E170 (Roche, Mannheim, Germany). The homeostasis model assessment-insulin resistance (HOMA-IR) was computed using the equation [fasting insulin concentration (µIU/mL)×fasting blood glucose level (mmol/L)/22.5] 18…”

Section: Methodsmentioning

confidence: 99%

<p>Usefulness Of Surrogate Markers Of Body Fat Distribution For Predicting Metabolic Syndrome In Middle-Aged And Older Korean Populations</p>

Shin¹,

Kim²

2019

DMSO

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BackgroundObesity markers, the lipid accumulation product (LAP), visceral adiposity index (VAI), triglyceride and glucose (TyG) index, and waist-to-height ratio (WHtR) are useful for assessing the risk of obesity-related cardiovascular disease. However, no previous study has assessed the usefulness of these four indices as predictors of metabolic syndrome among middle-aged and older Korean populations.PurposeTo investigate the usefulness of LAP, VAI, TyG index, and WHtR as predictors of metabolic syndrome in middle-aged and older Korean populations.MethodsThis study included 15,490 male and female adults aged 40 years or older who underwent a medical check-up in a general hospital located in a Korean metropolitan area between January 2015 and December 2016. The diagnostic criteria for metabolic syndrome suggested by the American Heart Association/National Heart Lung and Blood Institute were used. LAP, VAI, and TyG index were computed based on the suggested mathematical models. WHtR was computed by dividing waist circumference by height. The independent sample t-test, one-way analysis of variance, Scheffe test, chi-square test, Pearson's correlation analysis, and logistic regression were used to analyze the data.ResultsLAP, VAI, TyG index, and WHtR were significantly related to metabolic syndrome in both sexes. Receiver operating characteristic curve analysis showed the following optimal cutoffs for LAP, VAI, TyG index, and WHtR: 33.97, 1.84, 8.81, and 0.51, respectively. After adjusting for latent confounding variables (age, systolic blood pressure, diastolic blood pressure, and waist circumference), LAP, VAI, TyG index, and WHtR were significantly correlated with metabolic syndrome. Area under the curve (AUC) values based on ROC curves showed that LAP, VAI, TyG index, and WHtR were reliable predictors of metabolic syndrome. LAP had the greatest AUC, suggesting that it was a more useful predictor than the other markers (AUC=0.917, 95% confidence interval: 0.913–0.922).ConclusionLAP, VAI, TyG index, and WHtR are useful predictors of metabolic syndrome in middle-aged and older Koreans, but LAP had the greatest diagnostic accuracy.

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“…In those studies, carriers of APOE4 had higher results with respect to LDL cholesterol, while carriers of the genotype APOE2 -the lowest [20]. In the studies conducted among 305 women in Korea, a negative relationship was found between apoE2 and the level of HDL cholesterol, whereas there was a positive relationship between APOE4 and the level of LDL cholesterol [21]. In the studies by Sertic et al, a significant relationship was observed between APOE and hypercholesterolaemia.…”

Section: Discussionmentioning

confidence: 89%

Cognitive functions, lipid profile, and Apolipoprotein E gene polymorphism in postmenopausal women

Bojar¹,

Owoc²,

Owoc³

et al. 2015

Ann Agric Environ Med.

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The objective of the study was investigation of the relationship between cognitive functions and lipid profile, BMI and change of body weight in postmenopausal women carriers of Apolipoprotein E gene polymorphisms (APOE). A group of 170 women was recruited to the study. The inclusion criteria were: minimum of two years after the last menstruation, FSH concentration 30 U/ml and no signs of dementia on the Montreal Cognitive Assessment (MoCA). A computerized battery of Central Nervous System Vital Signs (CNS VS) was used for diagnostic cognitive functions. APOE genotype was performed by multiplex PCR. In blood plasma were determined: triglycerides, total cholesterol and its fractions: HDL cholesterol and LDL cholesterol. Statistical analysis was performed using two-way analysis of variance in STATISTICA software. In the postmenopausal women examined, the carrier state of APOE gene polymorphism was associated with the level of triglycerides, and results concerning three cognitive functions: executive functions, psychomotor speed, and cognitive flexibility. Loss of body weight in postmenopausal women was related with lower results in neurocognitive index and the majority of cognitive functions. The results concerning cognitive functions in postmenopausal women in the study were not significantly related with lipid profile. Significant differences were observed according to APOE gene polymorphism in correlations between LDL/HDL and CHOL/HDL ratios, and results in the processing speed and reaction time, as well as between the BMI and results in processing speed in the postmenopausal women examined.

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The Association Between Apolipoprotein E Genotype and Lipid Profiles in Healthy Woman Workers

Abstract: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.

Cited by 14 publications

References 26 publications

Association Between Four Anthropometric Indexes and Metabolic Syndrome in US Adults

Association Between Four Anthropometric Indexes and Metabolic Syndrome in US Adults

<p>Usefulness Of Surrogate Markers Of Body Fat Distribution For Predicting Metabolic Syndrome In Middle-Aged And Older Korean Populations</p>

Cognitive functions, lipid profile, and Apolipoprotein E gene polymorphism in postmenopausal women

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