The Association between Carotenoids and Head and Neck Cancer Risk

Brewczyński, Adam; Jabłońska, Beata; Kentnowski, M.; Mrowiec, Sławomir; Składowski, Krzysztof; Rutkowski, T.

doi:10.3390/nu14010088

Cited by 13 publications

(14 citation statements)

References 51 publications

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“…Those with greater pre-intervention carotene concentrations in their plasma or diets reduced cancer incidence (75). A highcarotene diet may also benefit cancer treatment (76,77).…”

Section: Dietary Consumptionmentioning

confidence: 99%

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review

et al. 2022

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Cancer is a severe condition characterized by uncontrolled cell division and increasing reported mortality and diagnostic cases. In 2040, an estimated 28.4 million cancer cases are expected to happen globally. In 2020, an estimated 19.3 million new cancer cases (18.1 million excluding non-melanoma skin cancer) had been diagnosed worldwide, with around 10.0 million cancer deaths. Breast cancer cases have increased by 2.26 million, lung cancer by 2.21 million, stomach by 1.089 million, liver by 0.96 million, and colon cancer by 1.93 million. Cancer is becoming more prevalent in Pakistan, with 19 million new cancer cases recorded in 2020. Food adulteration, gutkha, paan, and nutritional deficiencies are major cancer risk factors that interplay with cancer pathogenesis in this country. Government policies and legislation, cancer treatment challenges, and prevention must be revised seriously. This review presents the current cancer epidemiology in Pakistan to better understand cancer basis. It summarizes current cancer risk factors, causes, and the strategies and policies of the country against cancer.

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“…Those with greater pre-intervention carotene concentrations in their plasma or diets reduced cancer incidence (75). A highcarotene diet may also benefit cancer treatment (76,77).…”

Section: Dietary Consumptionmentioning

confidence: 99%

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review

et al. 2022

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“…Clinicians are therefore constantly looking for new prognostic biomarkers to better predict the aggressiveness of these cancers, but also for predictive biomarkers in order to select the patients that are most likely to respond to new therapies. HNSCC are mostly associated with alcohol and tobacco consumption but also with human papillomavirus (HPV) infection, and they are less reported to diet [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Dealing with Macrophage Plasticity to Address Therapeutic Challenges in Head and Neck Cancers

Furgiuele

Descamps

Cascarano

et al. 2022

IJMS

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The head and neck tumor microenvironment (TME) is highly infiltrated with macrophages. More specifically, tumor-associated macrophages (TAM/M2-like) are one of the most critical components associated with poor overall survival in head and neck cancers (HNC). Two extreme states of macrophage phenotypes are described as conducting pro-inflammatory/anti-tumoral (M1) or anti-inflammatory/pro-tumoral (M2) activities. Moreover, specific metabolic pathways as well as oxidative stress responses are tightly associated with their phenotypes and functions. Hence, due to their plasticity, targeting M2 macrophages to repolarize in the M1 phenotype would be a promising cancer treatment. In this context, we evaluated macrophage infiltration in 60 HNC patients and demonstrated the high infiltration of CD68+ cells that were mainly related to CD163+ M2 macrophages. We then optimized a polarization protocol from THP1 monocytes, validated by specific gene and protein expression levels. In addition, specific actors of glutamine pathway and oxidative stress were quantified to indicate the use of glutaminolysis by M2 and the production of reactive oxygen species by M1. Finally, we evaluated and confirmed the plasticity of our model using M1 activators to repolarize M2 in M1. Overall, our study provides a complete reversible polarization protocol allowing us to further evaluate various reprogramming effectors targeting glutaminolysis and/or oxidative stress in macrophages.

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“…Certain types of cancer have also been extensively studied in relation to carotenoid intake [ 37 ]. For example, diets rich in carotenoids have been associated with a lower incidence of Head and neck cancer (HNC), lung cancer, and breast cancer [ [38] , [39] , [40] ]. In addition, lutein and zeaxanthin have shown potential protective effects against age-related macular degeneration (AMD) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of serum carotenoids with asthma and mortality in the US adults

Zhang,

Li,

Zheng

2024

Heliyon

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The Association between Carotenoids and Head and Neck Cancer Risk

Cited by 13 publications

References 51 publications

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review

Dealing with Macrophage Plasticity to Address Therapeutic Challenges in Head and Neck Cancers

Associations of serum carotenoids with asthma and mortality in the US adults

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