The association between carotid-femoral pulse-wave velocity and lung function in the Swedish CArdioPulmonary bioImage study (SCAPIS) cohort

Zaigham, Suneela; Östgren, Carl-Johan; Persson, Margaretha; Muhammad, Iram Faqir; Nilsson, Peter M.; Wollmer, Per; Engvall, Jan; Engström, Gunnar

doi:10.1016/j.rmed.2021.106504

Cited by 11 publications

(19 citation statements)

References 45 publications

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“…Our finding that greater lung function was cross-sectionally associated with less stiff arteries largely supports previously published research. 17,[19][20][21][22]24,25 Bolton et al 19 function in later-life with lung function 20 years earlier at midlife in terms of associations with central arterial stiffness and concluded that lung function at mid-life was a better predictor of later-life arterial stiffness than measures of lung function later in life. 19 However, our findings suggest that lung function at mid-life and later-life were both associated with later-life arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

“…Most prior studies of lung function and arterial stiffness, as measured by pulse wave velocity (PWV), have been cross sectional, and support an inverse association between lung function and arterial stiffness. The majority of cross-sectional studies assessing expiratory function, measured by forced expiratory volume in one second (FEV 1 ), found poor expiratory function to be associated with greater arterial stiffness, [17][18][19][20][21][22] while some did not. 9,23 Other studies have assessed the cross-sectional association of lung capacity, measured by force vital capacity (FVC), and arterial stiffness, finding mixed results: some studies found poor lung capacity to be associated with stiffer arteries, 19,[21][22][23][24][25] while others did not.…”

Section: Introductionmentioning

confidence: 99%

“…The majority of cross-sectional studies assessing expiratory function, measured by forced expiratory volume in one second (FEV 1 ), found poor expiratory function to be associated with greater arterial stiffness, [17][18][19][20][21][22] while some did not. 9,23 Other studies have assessed the cross-sectional association of lung capacity, measured by force vital capacity (FVC), and arterial stiffness, finding mixed results: some studies found poor lung capacity to be associated with stiffer arteries, 19,[21][22][23][24][25] while others did not. 18 To our knowledge, only two studies have examined the relationship between lung function and central arterial stiffness prospectively, and only one in terms of lung function changes over time.…”

Section: Introductionmentioning

confidence: 99%

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Decline in Lung Function From Mid-to Late-Life With Central Arterial Stiffness: The Atherosclerosis Risk in Communities Study

et al. 2022

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We investigated the association of lung function at mid-life, later in life, and its 20-year decline, with arterial stiffness later in life. We examined 5720 Atherosclerosis Risk in Communities Study participants who attended Visits 1 (1987-1989) and 5 (2011-2013). Lung function measures were forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), obtained at Visits 1, 2 (1990–1992), and 5. Central artery stiffness (carotid-femoral pulse wave velocity [cfPWV]) was measured at Visit 5. We evaluated associations of lung function with later-life central artery stiffness and cfPWV >75th percentile by multivariable linear and logistic regressions. Lung function at Visit 1 (FEV1 β: −26, 95% Confidence Interval [CI]: −48, −5; FVC β: −14, 95% CI: −32, 5) and Visit 5 (FEV1 β: −22, 95% CI: −46, 2; FVC β: −18, 95% CI: −38, 2) were inversely associated with cfPWV at Visit 5, and with odds of high cfPWV in fully adjusted models. Twenty-year decline in lung function was not associated with continuous or dichotomous measures of arterial stiffness (FEV1 β: 11, 95% CI: −46, 68; FVC β: −4, 95% CI: −52, 43). Lung function at mid-life and late-life was inversely associated with arterial stiffness in later life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Decline in Lung Function From Mid-to Late-Life With Central Arterial Stiffness: The Atherosclerosis Risk in Communities Study

et al. 2022

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“…Carotid–femoral pulse wave velocity (PWV) was measured by trained biomedical scientists using an applanation tonometer according to a previously published protocol. 21 In brief, measurements were made twice using the SphygmoCor XCEL device (from Atcor Medical, Sydney, NSW, Australia). The average of these measurements was used for analysis, and calculated using a correction factor of 0.8 in accordance with current international guidelines.…”

Section: Methodsmentioning

confidence: 99%

Home Blood Pressure Compared With Office Blood Pressure in Relation to Dysglycemia

Engvall

Östgren

Nyström

et al. 2022

American Journal of Hypertension

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Background Masked hypertension is more common in individuals with type 2 diabetes than in individuals with normoglycemia. We aimed to explore if there is a discrepancy between office blood pressure (office BP) and home blood pressure monitoring (HBPM) in relation to HbA1c as well as glycemic status in 5,029 middle-aged individuals. Method HBPM was measured in a subsample of 5,029 participants in The Swedish CardioPulmonary BioImage Study (SCAPIS), a population-based cohort of 50-64 years old participants. Both office BP and HBPM were obtained after five minutes’ rest using the semi-automatic Omron M10-IT oscillometric device. White coat effect was calculated by subtracting systolic HBPM from systolic office BP. Participants were classified according to glycemic status: Normoglycemia, prediabetes or diabetes based on fasting glucose, HbA1c value and self-reported diabetes diagnosis. Results Of the included 5,025 participants, 947 (18.8%) had sustained hypertension, 907 (18.0%) reported taking antihypertensive treatment and 370 (7.4%) had diabetes mellitus. Both systolic office BP and HBPM increased according to worsened glycemic status (p for trend 0.002 and 0.002, respectively). Masked hypertension was more prevalent in participants with dysglycemia compared to normoglycemia (p=0.036). The systolic white coat effect was reversely associated with HbA1c (p=0.012). Conclusion The systolic white coat effect was reversely associated with HbA1c, and the prevalence of masked hypertension increased with dysglycemia.

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“…As for the sex differences, at least two studies ( 143 , 144 ) have shown that males in comparison to females have stiffer arteries, assessed by carotid-femoral pulse wave velocity (cfPWV), which could help to predict the loss of lung function in male subjects. The Swedish CArdioPulmonary bioImage Study (SCAPIS) ( 145 ) observed the reduction in PWV by 1-SD increase in Forced Expiratory Volume 1 sec (FEV1) and diffusing capacity for carbon monoxide only in males but not in females from healthy populations.…”

Section: Early Vascular Aging: Sex and Gendermentioning

confidence: 99%

Gender dimension in cardio-pulmonary continuum

Hernandez

Laučytė-Cibulskienė²,

Ward³

et al. 2022

Front. Cardiovasc. Med.

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Cardio-pulmonary diseases, which were once regarded as a man's illness, have been one of the leading causes of morbidity and mortality for both men and women in many countries in recent years. Both gender and sex influence the functional and structural changes in the human body and therefore play an important role in disease clinical manifestation, treatment choice, and/or response to treatment and prognosis of health outcomes. The gender dimension integrates sex and gender analysis in health sciences and medical research, however, it is still relatively overlooked suggesting the need for empowerment in the medical research community. Latest advances in the field of cardiovascular research have provided supportive evidence that the application of biological variables of sex has led to the understanding that heart disease in females may have different pathophysiology compared to males, particularly in younger adults. It has also resulted in new diagnostic techniques and a better understanding of symptomatology, while gender analysis has informed more appropriate risk stratification and prevention strategies. The existing knowledge in the pulmonary field shows the higher prevalence of pulmonary disorders among females, however, the role of gender as a socio-cultural construct has yet to be explored for the implementation of targeted interventions. The purpose of this review is to introduce the concept of gender dimension and its importance for the cardiopulmonary continuum with a focus on shared pathophysiology and disease presentation in addition to interrelation with chronic kidney disease. The review presents basic knowledge of what gender dimension means, and the application of sex and gender aspects in cardiovascular medicine with a specific focus on early pulmonary development, pulmonary hypertension, and chronic obstructive pulmonary disease (COPD). Early vascular aging and inflammation have been presented as a potential pathophysiological link, with further interactions between the cardiopulmonary continuum and chronic kidney disease. Finally, implications for potential future research have been provided to increase the impact of gender dimension on research excellence that would add value to everybody, foster toward precision medicine and ultimately improve human health.

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The association between carotid-femoral pulse-wave velocity and lung function in the Swedish CArdioPulmonary bioImage study (SCAPIS) cohort

Cited by 11 publications

References 45 publications

Decline in Lung Function From Mid-to Late-Life With Central Arterial Stiffness: The Atherosclerosis Risk in Communities Study

Decline in Lung Function From Mid-to Late-Life With Central Arterial Stiffness: The Atherosclerosis Risk in Communities Study

Home Blood Pressure Compared With Office Blood Pressure in Relation to Dysglycemia

Gender dimension in cardio-pulmonary continuum

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