The association between chronic periodontitis and oral Helicobacter pylori: A meta-analysis

Wei, Xiang; Zhao, Hongxia; Ma, Chuan; Zhang, Aobo; Feng, Hao; Zhang, Dong; Liu, Chao

doi:10.1371/journal.pone.0225247

Cited by 28 publications

(25 citation statements)

References 40 publications

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“…In the oral cavity, the microorganisms in dental biofilm and saliva may play a role as a potential reservoir for H. pylori [ 41 ]. Recently, oral H. pylori was found to a potential risk factor for the development of CP [ 42 ]. In addition, a systematic review demonstrated a great reduction in H. pylori among patients who received periodontal therapy [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study

Huang

Yang

Wang

et al. 2021

IJERPH

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Migraine is considered to be a neurovascular disease that manifests as a throbbing headache, possibly caused by the activation of the trigeminovascular system. Several studies have supported the role of inflammation in the pathogenesis of migraine. Chronic periodontitis (CP) is an infectious inflammatory disease triggered by bacterial products evoking an immune response which could result in the destruction of the periodontium. However, little is known about the longitudinal association between CP and migraine. In this study, we designed a nationwide population-based cohort study to investigate the risk of migraine and CP exposure in Taiwan. In total, 68,282 patients with CP were identified from the National Health Insurance Research Database (NHIRD), and 68,282 comparisons were randomly captured and matched by age, sex, monthly income, urbanization and comorbidities. The association between CP exposure and migraine risk was evaluated by Cox proportional hazards regression models. In this study, 785 migraine patients were identified in the CP cohort, and 641 migraine cases were found in the non-CP cohort. The incidence rate of migraine was significantly higher in the CP cohort than the non-CP cohort (adjusted HR: 1.21, 95% CI: 1.09–1.34, p < 0.001) during the 13-year follow-up period. Females had a 2.69-fold higher risk for migraine than males (95% CI: 2.38–3.04, p < 0.001). In summary, CP is associated with an increased risk of subsequent migraine in Taiwan.

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Section: Discussionmentioning

confidence: 99%

Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study

Huang

Yang

Wang

et al. 2021

IJERPH

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“…A meta‐analysis was performed on 11 studies including 1993 participants (1319 with chronic periodontitis (CP) and 674 controls) who had oral and gastric H pylori tested by PCR and rapid urease test. When compared to the H pylori ‐negative population, H pylori ‐positive patients had a significantly increased risk of CP (OR = 3.42, 95% CI = 2.71‐4.31) 19 . Another meta‐analysis of 13 studies involving 6800 patients, also suggested that the risk of periodontal diseases in the patients with oral H pylori positivity was 2.31 (95% CI, 1.00‐2.68) times higher than those with H pylori negativity 20 .…”

Section: Helicobacter Pylori Acquisitionmentioning

confidence: 99%

Review: Epidemiology of Helicobacter pylori

et al. 2020

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This review summarizes the recent knowledge on the epidemiology of Helicobacter pylori and the potential modes of transmission. In addition to English language publications, the authors have included original full‐text publications from Russia and Latin America published in the original languages. High H pylori prevalence has been reported in Russia, Jordan, Iran, China, and Latin American countries as well as in Arctic populations in Canada. Indigenous inhabitants in the Arctic were found to be infected substantially more frequently than non‐indigenous inhabitants. In Amsterdam, the Netherlands, the ethnic minority groups were at a significantly higher risk of being H pylori seropositive compared to the Dutch population. For the first time, data on the prevalence from Armenia have been published indicating 41.5% H pylori prevalence. Convincing evidence on the decline of H pylori prevalence in Southeast Hungary and Taiwan was published. A study from Chile suggested high infection rates in newborns during the first month after birth. Two meta‐analyses covered the potential correlation between H pylori and periodontal diseases, therefore addressing the potential oro‐oral transmission rates. Periodontal disease was found to be more prevalent in H pylori‐infected subjects. Other studies addressed the potential role of drinking water and food products as well as socioeconomic factors in transmitting the infection. Several studies in Asia addressed annual reinfection rates of H pylori, ranging from 1.5% in China to 3.1% in Korea. Finally, a review was published on the current evidence and future perspective of analysing H pylori in ancient human remains by a metagenomic approach.

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“…Generally, all ages are affected, this in combination with the condition of infection at the right time by the specific bacterium with good oral hygiene; conditions that must simultaneously be in combination with each other. The study aims to collect retrospective and cross-sectional data on the prevalence of chronic periodontitis [5][6][7][8][9][10]. Having both types of studies for the purpose of data collection, it is possible to find possible correlations on the effect of risk factors for the occurrence of chronic periodontitis, the effect of local dental factors on the formation of bacterial plaque and then on the occurrence of chronic, local or generalized periodontitis, or the extent of this infection divided or not depending on the sex, age of the affected individuals.…”

Section: Introductionmentioning

confidence: 99%

“…Having both types of studies for the purpose of data collection, it is possible to find possible correlations on the effect of risk factors for the occurrence of chronic periodontitis, the effect of local dental factors on the formation of bacterial plaque and then on the occurrence of chronic, local or generalized periodontitis, or the extent of this infection divided or not depending on the sex, age of the affected individuals. An important element that gives the opportunity through this study to collect and process the recorded data, is the possibility of finding correlations of this diagnosis and the presence of other lesions of hard and soft tissues [2,5,7,[11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Chronic Periodontitis: A Retrospective Cross-sectional Study

et al. 2021

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Introduction: The characteristic appearance of chronic periodontitis with the absence of bacterial plaque or with minimal amounts of it, but with the presence of gingival health, expressed in the specific pink color of the gingiva, is associated with active stages of the disease and its inactive stages. The aim of this study is to compare cross-sectional and retrograde data on the prevalence of chronic periodontitis in the two respective groups of patients, evaluated according to specific periodontal diagnostic tools. Materials and Methods: The study was applied in two groups of patients: the first group of patients presented at the dental clinic in the period October 2019 - January 2020 and the second group; in the period October-November in the annual interval 2010-2018. In these patients, periodontal status was assessed based on probing values, bacterial plaque index, bleeding index, and amount of gingival fluid in specific dentures. The number of natural teeth and the number of teeth replaced with fixed prosthetics were recorded. Results: For both cross-sectional and retrograde data, chronic periodontitis is a disease that affects young people, with a higher prevalence in females. This data is expressed with high ratios of tooth loss for periodontal reasons. The highest dental care for replacement with fixed prosthetics, again belongs to the female sex, but with a high bacterial plaque index. The high index of gingival hemorrhage with reduced bacterial plaque index, are data with high percentages both for the group of patients cross-sectional data and for the group of patients with retrograde data. Conclusions: The high prevalence of chronic periodontitis at a young age indicates a poor prognosis of this disease at older ages. Gingival recession associated with loss of attachment for patients with chronic periodontitis have higher values at age intervals 31-50 years, intervals where systemic pathologies are in the stages of development and stabilization in the human body. Doi: 10.28991/SciMedJ-2021-0301-5 Full Text: PDF

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The association between chronic periodontitis and oral Helicobacter pylori: A meta-analysis

Cited by 28 publications

References 40 publications

Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study

Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study

Review: Epidemiology of Helicobacter pylori

Prevalence of Chronic Periodontitis: A Retrospective Cross-sectional Study

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