The association between endocrine disrupting chemicals and MAFLD: Evidence from NHANES survey

Association of Di(2-ethylhexyl) Terephthalate and Its Metabolites with Nonalcoholic Fatty Liver Disease: An Epidemiology and Toxicology Study

“…An investigation found that the DEHTP metabolites (MECPTP and MEHHTP) are positively associated with 8-iso-prostaglandin F 2α in pregnant women, which is a reliable indicator of oxidative stress in vivo . Oxidative stress is central to NAFLD pathogenesis and is a crucial factor in NAFLD progression driven by some environmental pollutants. , Lei et al recently observed that estimated DEHTP exposure concentrations were positively associated with the risk of metabolic dysfunction-associated fatty liver disease in humans . The human and in vitro studies proposed in this work aimed to further refine this finding.…”

“…59,60 Lei et al recently observed that estimated DEHTP exposure concentrations were positively associated with the risk of metabolic dysfunction-associated fatty liver disease in humans. 61 The human and in vitro studies proposed in this work aimed to further refine this finding. We found the hydroxyl metabolite MEHHTP derived from DEHTP ingested by the body may be a triggering cause of NAFLD.…”

Urinary caffeine and its metabolites in association with advanced liver fibrosis and liver steatosis: a nationwide cross-sectional study

“…The participant who reported no physical activity was considered inactive, while <30 MET-h/week was defined as low activity, 30–60 MET-h/week was classified as medium activity, and ≥60 MET-h/week was classified as high activity. 42 For dietary factors, daily energy and alcohol intake were obtained from two 24-hour dietary recalls, with mean values being utilized for analysis. BMI was calculated as weight (kg) divided by the square of the height (m 2 ) and classified into two groups (<25 kg m −2 and ≥25 kg m −2 ).…”

“…Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or currently using antihypertensive medications. 42 Blood pressure was measured after resting quietly in a seated position for five minutes, and the mean value of blood pressure measurements taken at all three times was used for analysis. The survey cycle corresponded to three periods: 2009–2010, 2011–2012, and 2013–2014.…”

The Interplay between Endocrine-Disrupting Chemicals and the Epigenome towards Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review

“…Some EDCs have been widely recognised as obesogens, contributing to obesity as well as other metabolic diseases in humans [ 4 ]. Moreover, many EDCs are metabolised in the liver; they appear to be closely associated with MASLD predisposition and also to cause significant epigenetic alterations that are inherited across generations, including DNA methylation, histone modification, and miRNA regulation [ 5 , 6 ]. These alterations lead to modified gene transcription/silencing, resulting in heritable changes in the epigenome that evidently persist across generations [ 4 ].…”