The association between glutathione S-transferase T1 and M1 gene polymorphisms and cardiovascular autonomic neuropathy in Slovak adolescents with type 1 diabetes mellitus

Vojtková, Jarmila; Ďurdík, Peter; Ciljakova, Miriam; Michnová, Zuzana; Turčan, Tomáš; Babušíková, Eva

doi:10.1016/j.jdiacomp.2012.07.002

Cited by 20 publications

(14 citation statements)

References 24 publications

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“…There is only one study, published in 2015, referring the GSTM1 and GSTT1 polymorphisms in a Romanian T2DM population [ 28 ] but according to our knowledge no other studies in Romania or in other countries investigated the effect of these polymorphisms in T2DM DSPN. In the medical literature we found only one study on GSTM1 and GSTT1 gene polymorphisms and cardiovascular autonomic neuropathy (CAN) in T1DM in Slovak adolescents [ 30 ] but we did not find studies regarding these gene polymorphisms in T2DM DSPN. This is the first study investigating the association between the combined effect of GSTM1 , GSTT1 , and GSTP1 genotypes in a population consisting of a control group and T2DM patients with and without DSPN in Romania and to our knowledge the first study of its kind to investigate the effect of these combined genotypes on the occurrence of DSPN in T2DM.…”

Section: Discussionmentioning

confidence: 85%

Influence ofGSTM1,GSTT1, andGSTP1Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk

et al. 2015

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Background and Aims. Diabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy. We investigated the relation between polymorphism in genes related to oxidative stress such as GSTM1, GSTT1, and GSTP1 and the presence of T2DM and diabetic neuropathy (DN). Methods. Samples were collected from 84 patients with T2DM (42 patients with DN and 42 patients without DN) and 98 healthy controls and genotyped by using polymerase chain reaction and restriction fragment length polymorphism method. Results. GSTP1 Ile105Val polymorphism was associated with the risk of developing T2DM (p = 0.05) but not with the risk of developing DN in diabetic cases. GSTM1 and GSTT1 gene polymorphisms were associated with neither the risk of developing T2DM nor the risk of DN occurrence in diabetic patients. No association was observed between the patients with T2DM and DSPN (diabetic sensorimotor peripheral neuropathy) and T2DM without DSPN regarding investigated polymorphism. Conclusion. Our data suggest that GSTP1 gene polymorphisms may contribute to the development of T2DM in Romanian population. GSTM1, GSTT1, and GSTP1 gene polymorphisms are not associated with susceptibility of developing diabetic neuropathy in T2DM patients.

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Section: Discussionmentioning

confidence: 85%

Influence ofGSTM1,GSTT1, andGSTP1Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk

et al. 2015

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“…Cinzia Ciccacci et al 36 carried out a case–control study to evaluate the contribution of TCF7L2 polymorphisms to diabetic complications, reporting that TCF7L2 genetic variability contributes to the progression of CAN. Vojtková et al 8 found that glutathione S-transferase T1 wild and GST T1/M1 wild/null represented a risk factor for progression of CAN. In this study, we focused on the effect of SCN10A and DM on CAN.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported associations of genetic polymorphisms with neuropathy susceptibility. For instance, associations have been found between polymorphisms of glutathione S-transferase and a higher risk of CAN development 8. Our previous study investigated the effects of interaction of HTN and uric acid on the disease 9.…”

Section: Introductionmentioning

confidence: 99%

Association and interaction analysis of diabetes mellitus andSCN10Afor cardiovascular autonomic neuropathy in a Chinese population

Zhou

Tang

et al. 2016

Postgraduate Medical Journal

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“…Babizhayev MA et al studied 446 patients with T1D of short duration (less than 3 years), with 226 of them having PDN and found no significant association between GST polymorphisms and PDN. In a study of 46 Slovak adolescents with T1D, 10 of whom with CAN, the relation of null alleles of GTSs polymorphism with the development of CAN was investigated . Although not statistically significant, the GSTM1 null genotype was more frequent in patients with CAN.…”

Section: Genetic Markers Of Diabetic Neuropathy Developmentmentioning

confidence: 99%

Diabetic neuropathy in children and adolescents with type 1 diabetes mellitus: Diagnosis, pathogenesis, and associated genetic markers

Kallinikou

Soldatou

Tsentidis

et al. 2019

Diabetes Metabolism Res

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Summary Diabetic neuropathy (DN) is a common long‐term complication of type 1 (T1D) and type 2 (T2D) diabetes mellitus, with significant morbidity and mortality. DN is defined as impaired function of the autonomic and/or peripheral nervous system, often subclinical, particularly in children and adolescents with T1D. Nerve conduction studies (NCS) and skin biopsies are considered gold‐standard methods in the assessment of DN. Multiple environmental and genetic factors are involved in the pathogenesis of DN. Specifically, the role of metabolic control and glycemic variability is of paramount importance. A number of recently identified genes, including the AKR1B1, VEGF, MTHFR, APOE, and ACE genes, contribute significantly in the pathogenesis of DN. These genes may serve as biomarkers to predict future DN development or treatment response. In addition, they may serve as the basis for the development of new medications or gene therapy. In this review, the diagnostic evaluation, pathogenesis, and associated genetic markers of DN in children and adolescents with T1D are presented and discussed.

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The association between glutathione S-transferase T1 and M1 gene polymorphisms and cardiovascular autonomic neuropathy in Slovak adolescents with type 1 diabetes mellitus

Cited by 20 publications

References 24 publications

Influence ofGSTM1,GSTT1, andGSTP1Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk

Influence ofGSTM1,GSTT1, andGSTP1Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk

Association and interaction analysis of diabetes mellitus andSCN10Afor cardiovascular autonomic neuropathy in a Chinese population

Diabetic neuropathy in children and adolescents with type 1 diabetes mellitus: Diagnosis, pathogenesis, and associated genetic markers

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