The Association between Helicobacter Pylori and Laryngopharyngeal Reflux in Laryngeal Pathologies

Abstract

We conducted a study to determine the presence or absence of Helicobacter pylori and laryngopharyngeal reflux (LPR) in 43 previously untreated patients who had presented with a laryngeal lesion. Our aim was to determine if there was any association among H pylori, LPR, and laryngeal lesions. H pylori status was determined by real-time polymerase chain reaction (PCR) assays of biopsy tissue obtained during direct laryngoscopy. The presence or absence of LPR was determined on the basis of patients' reflux symptom index (RSI) and reflux finding score (RFS), which were based on their questionnaire responses and findings on endoscopic examination of the larynx, respectively. Patients with an RSI of 14 or more and/or an RFS of 8 or more were considered to have LPR. H pylori was present in 24 patients (55.8%) and absent in 19 (44.2%)-not a statistically significant difference. The prevalence of LPR was higher than the prevalence of H pylori; it was present in 30 patients (69.8%) and absent in 13 (30.2%). The difference was statistically significant (p = 0.01). We found no association between H pylori status and LPR status. Additionally, we analyzed two subgroups based on whether their lesions were benign or malignant/premalignant and found a significant relationship between LPR positivity and the presence of malignant/ premalignant laryngeal lesions (p = 0.03). We found no association between H pylori status and either of the two subgroup categories.

Detection of Helicobacter pylori in patients with head and neck cancer: Results from a prospective comparative study combining serology, polymerase chain reaction, and rapid urease test

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“…H. pylori bacteria may also be detected in the UADT because of gastric contamination . H. pylori ‐contaminated gastric fluids may reach the UADT in a retrograde fashion and lead to positive PCR results in the UADT.…”

The Role of Pepsin in LPR: Will It Change Our Diagnostic and Therapeutic Approach to the Disease?

“…The prevalence and severity of LPR was significantly higher in cancer patients than the controls. Furthermore, Cekin et al [52] reported the prevalence of LPR in new patients presenting with a laryngeal lesion was 69.8 % and there was a significant relationship between LPR positivity and presence of a malignant/premalignant laryngeal lesion (p = 0.03). Additional studies examined the direct effect of various individual components of refluxate including acid, pepsin and bile salts on laryngeal cells.…”

Association between Helicobacter pylori and Pharyngolaryngeal Carcinomas: The Role in the Development and Prognostic Significance

“…pylori infection is one of the most common bacterial infections in humans, affecting more than half of the world's population [13] . Its prevalence is 30-40% in developed countries and reaches up to 80-90% in underdeveloped countries [14,15] .…”