The association between high-sensitivity C-reactive protein and hypertension in women of the CARDIA study

Abstract

Objective The aim of this study was to determine the prevalence of hypertension in mid-life women, characterize the association between high sensitivity C-reactive protein (hs-CRP) and hypertension in women, and describe differences in hypertension prevalence by menopausal stage. Methods We included 1625 women, aged 43-55 years, with measurements of hs-CRP and detailed reproductive histories in the Coronary Artery Risk Development in Young Adults Study at follow up year 25. Prevalent hypertension was defined as a systolic blood pressure of 140 mm hg, or diastolic blood pressure of 90 mm hg, or greater or use of antihypertensive medications. Logistic regression was used for analysis. Results The prevalence of hypertension was 25.8 %, 37.8 %, and 39.0 % in premenopausal, perimenopausal and postmenopausal women respectively. The median (25th, 75th percentiles) of hs-CRP was 3.08 (1.12, 7.98) μg/ml and 1.18 (0.48, 3.15) μg/ml in women with and without hypertension respectively. After adjusting for confounders, metabolic factors and body mass index (BMI), a doubling (100% increment) in hs-CRP levels was significantly associated with hypertension in premenopausal (1.27 [1.01 - 1.59]) but not in perimenopausal (1.12 [0.99 - 1.27]) or postmenopausal (1.09 [0.95 - 1.26]) women. Conclusions Hypertension was common in mid-life women. The association of hs-CRP and hypertension was consistent across menopausal stages. The association of hs-CRP with hypertension was independent of BMI in premenopausal but not in perimenopausal or postmenopausal women.

The association between mean platelet volume and inflammation in geriatric patients with emergency hypertension

“…Therefore, any relationship between the severity of inflammation and acutely increased BP remains unclear. We explored the relationships between inflammatory markers such as NLR and hs-CRP level, and the severity of HT in geriatric patients admitted to our ED with HT attacks, and both parameters were significantly elevated in geriatric patients with HT emergencies rather than urgencies (23). Previous studies also revealed a clear link between the levels of hs-CRP and MPV.…”

Serum C‐reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice

“…It is also of interest that the risks of CVD associated with CRP levels were lower for men than women (Ebong et al, ; Shrivastava et al, ). This results reflect the effect modification by sex.…”

Successful treatment of obesity and insulin resistance via ketogenic diet status post Roux-en-Y

“…Elevated hs-CRP is a risk factor for CVD as well as HTN, wherein HTN increases proportionate to increased hs-CRP 41. Moreover, this association is more pronounced in women who are postmenopausal, independent of BMI 39. This correlation, in theory, is due to inflammation, obesity and loss of oestrogen in postmenopausal HTN 39.…”

“…Moreover, this association is more pronounced in women who are postmenopausal, independent of BMI 39. This correlation, in theory, is due to inflammation, obesity and loss of oestrogen in postmenopausal HTN 39. CRP contributes to HTN by diminishing the production of nitric oxide (NO) from endothelial cells, resulting in vasodysregulation and endothelial dysfunction 39–42 44.…”