The Association Between <i>AXIN2</i> Gene Polymorphisms and the Risk of Breast Cancer in Chinese Women

Dai, Jianbo; Gao, Haiyan; Xue, Jiao; Lin, Weijia; Zheng, Lin

doi:10.1089/gtmb.2018.0309

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…An increase in CCN2 expression levels has been shown to play an important role in the invasion and metastasis of breast cancer [ 37 ]. The polymorphisms rs11079571 and rs3923087 of the AXIN2 gene were reported to be associated with an increased risk of breast cancer [ 38 ]. The metastasis of breast cancer can be suppressed by activating the canonical BMP4-SMAD7 signaling axis [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing

Liang

Pan

Xia

et al. 2021

Aging

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The function of oleanolic acid (OA) in various types of cancer has been reported frequently, especially for breast cancer. However, the regulation of breast tumor growth in response to OA treatment has not been studied in depth. Here, we first explored the effect of OA treatment on breast tumors in vitro and in vivo and then used RNA-seq technology to study the effect and molecular mechanism of OA treatment of MCF-7 cells, particularly at the level of functional genomics. The results showed that 40 μM OA treatment could significantly inhibit the proliferation and induce the apoptosis of MCF-7 cells. Through analysis of RNA sequencing data quality and differentially expressed genes (DEGs), 67 significantly downregulated genes and 260 significantly upregulated genes were identified to be involved in OA treatment of MCF-7 cells. Among these genes, 43 unique DEGs were enriched in several signaling pathways and Gene Ontology terms, such as p53 signaling pathway, TNF signaling pathway and mTOR signaling pathway. Six downregulated genes, including THBS1, EDN1, CACNG4, CCN2, AXIN2 and BMP4, as well as six upregulated genes, including ATF4, SERPINE1, SESN2, PPARGC1A, EGR1 and JAG1, were selected as target genes in response to OA treatment. The inhibitory effect of OA on breast cancer was also found in the following mouse experiments. Our study provides evidence and molecular support for the treatment of breast cancer with OA.

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Section: Resultsmentioning

confidence: 99%

Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing

Liang

Pan

Xia

et al. 2021

Aging

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“…Chapman et al observed genetic changes (mostly deletions) of A XIN 2 in 7% of human adrenocortical adenomas tumor samples and 17% of adrenocortical carcinomas tumor samples [69]. Consistent with the idea that A XIN 2 might act as a tumor suppressor, A XIN 2 downregulation is associated with poorer overall survival of patients with breast cancer [70]. However, in vivo findings also suggest A XIN 2 as tumor-promoting, as it upregulates the transcriptional repressor, SNAI1, leading to increased EMT and metastatic activity in colorectal cancers in mice [71].…”

Section: Wnt Signaling In Cancermentioning

confidence: 88%

WNT Signaling in Disease

Kaur

Bunnag

et al. 2019

Cells

185

154

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“… 155 , 158 , 160 Axin2 dysfunction was associated with a variety of tumors, including endometrial cancer, 161 CRC, 162 – 165 lung cancer, 166 , 167 and breast cancer. 168 – 170 In these cancers, Axin2 performed suppressive roles by mainly constraining the level of β-catenin.…”

Section: Intracellular Compositionsmentioning

confidence: 99%

Wnt/β-catenin signaling in cancers and targeted therapies

Chen

et al. 2021

Sig Transduct Target Ther

345

160

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Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression, development of poor prognostics, and even ascendence of the cancer-associated mortality. Early experimental investigations have proposed the theoretical potential that efficient repression of this signaling might provide promising therapeutic choices in managing various types of cancers. Up to date, many therapies targeting Wnt/β-catenin signaling in cancers have been developed, which is assumed to endow clinicians with new opportunities of developing more satisfactory and precise remedies for cancer patients with aberrant Wnt/β-catenin signaling. However, current facts indicate that the clinical translations of Wnt/β-catenin signaling-dependent targeted therapies have faced un-neglectable crises and challenges. Therefore, in this study, we systematically reviewed the most updated knowledge of Wnt/β-catenin signaling in cancers and relatively targeted therapies to generate a clearer and more accurate awareness of both the developmental stage and underlying limitations of Wnt/β-catenin-targeted therapies in cancers. Insights of this study will help readers better understand the roles of Wnt/β-catenin signaling in cancers and provide insights to acknowledge the current opportunities and challenges of targeting this signaling in cancers.

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The Association Between AXIN2 Gene Polymorphisms and the Risk of Breast Cancer in Chinese Women

Cited by 11 publications

References 20 publications

Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing

Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing

WNT Signaling in Disease

Wnt/β-catenin signaling in cancers and targeted therapies

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