2013
DOI: 10.1111/epi.12049
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The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin

Abstract: SUMMARYPurpose: This study sought to determine the association between BsmI polymorphism and bone mineral density, 25-hydroxyvitamin D, and parathyroid hormone levels in patients with epilepsy. Methods: We recruited ambulatory young adults with epilepsy who were taking phenytoin. Data regarding demographics, basic laboratory studies, history of clinical epilepsy, parathyroid hormone, and vitamin D levels, as well as BsmI polymorphism of the vitamin D receptor (VDR) gene, were obtained. The bone mineral density… Show more

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Cited by 14 publications
(9 citation statements)
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“…A cross-sectional study evaluated BsmI polymorphism of the VDR gene in 73 long-term users of antiepileptic monotherapy and found that patients with at least one allele had lower serum 25-OH vitamin D levels with a concomitant rise in serum PTH levels [76]. In a more recent study investigating ambulatory young adult patients with epilepsy on PHT monotherapy, BsmI polymorphism was found to be associated with lower BMD and 25-OH vitamin D levels [77]. Besides inducing P450 system, PHT and CBZ have been reported to inhibit bone proliferation by diminishing bone formation in therapeutic doses [13].…”
Section: Mechanism Of Vitamin D Deficiency In Epilepsy Treatmentmentioning
confidence: 99%
“…A cross-sectional study evaluated BsmI polymorphism of the VDR gene in 73 long-term users of antiepileptic monotherapy and found that patients with at least one allele had lower serum 25-OH vitamin D levels with a concomitant rise in serum PTH levels [76]. In a more recent study investigating ambulatory young adult patients with epilepsy on PHT monotherapy, BsmI polymorphism was found to be associated with lower BMD and 25-OH vitamin D levels [77]. Besides inducing P450 system, PHT and CBZ have been reported to inhibit bone proliferation by diminishing bone formation in therapeutic doses [13].…”
Section: Mechanism Of Vitamin D Deficiency In Epilepsy Treatmentmentioning
confidence: 99%
“…Furthermore, it has recently been reported that BsmI polymorphism in epilepsy patients taking phenytoin was strongly associated with lower BMD. [20] Similarly, a case–controlled study in Iran suggested a strong association between the VDR BsmI polymorphism and LS BMD of Iranian women. [21] …”
Section: Discussionmentioning
confidence: 99%
“…Although the leading hypothesis is that AEDs increase vitamin D metabolism through increased expression of CYP450 enzymes, certainly other mechanisms leading to increased bone turnover are involved, such as direct effects of the AEDs on osteoblast-like cells. More recently, an association between Bsml vitamin D receptor (VDR) polymorphism and low bone mineral density in patients with epilepsy treated with phenytoin has been reported [67]. Young adult patients with epilepsy carrying the Bsml polymorphism demonstrated lower bone mineral density than patient with epilepsy carrying the wild-type VDR gene [67].…”
Section: Discussionmentioning
confidence: 99%
“…More recently, an association between Bsml vitamin D receptor (VDR) polymorphism and low bone mineral density in patients with epilepsy treated with phenytoin has been reported [67]. Young adult patients with epilepsy carrying the Bsml polymorphism demonstrated lower bone mineral density than patient with epilepsy carrying the wild-type VDR gene [67]. These results suggest that allelic variation in the VDR gene may predispose patients to lower bone mineral density.…”
Section: Discussionmentioning
confidence: 99%