The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults

Chanti‐Ketterl, Marianne; Gamaldo, Alyssa A.; Andel, Ross; Thorpe, Roland J.

doi:10.1177/0898264317690866

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…Despite the lack of consensus in associations between biomarkers and frailty in previous studies [ 11 ], a moderate link between haemoglobin and frailty [ 26 ] was reported, while there was a reported link between low HDL level and ADL-related disability [ 27 ]. Supporting our hypothesis, the associations between these markers and the physical aspect of frailty extend additional support to these existing findings.…”

Section: Discussionmentioning

confidence: 99%

Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

Cable

Hiyoshi

Kondo

et al. 2018

BioMed Research International

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We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22–3.23; RRR = 1.36, 95% CI = 1.33–1.39; RRR = 1.36, 95% CI = 1.23–1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91–2.70; RRR = 1.59, 95% CI = 1.51–1.68; RRR = 1.40, 95% CI = 1.28–1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23–2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.

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Section: Discussionmentioning

confidence: 99%

Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

Cable

Hiyoshi

Kondo

et al. 2018

BioMed Research International

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“…Due to the physiological function of HDL-C, HDL-C is regarded as a positive factor of health in the whole population. Relevant research demonstrates that the higher the level of HDL-C, the better the functional status, 29 ADL, 30 and cognitive function 14 of the elderly. This study found that the increase of HDL-C in centenarians had the strongest protective effect on ADL disability, suggesting that the prevention of hypoHDL-C in the elderly and centenarians has important health significance.…”

Section: Discussionmentioning

confidence: 99%

<p>Higher Normal Levels of Triglyceride and Low and High-Density Lipoprotein Cholesterol Might Have a Protective Effect Against Activities of Daily Living Disability Within Chinese Female Centenarians: A Cross-Sectional, Complete Sample Study</p>

Wang¹,

Liu²,

Yang³

et al. 2020

CIA

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Background and Objective: Activities of daily living (ADL) disability seriously affects the quality of life in the elderly. This study aims to examine the prevalence of ADL disability and its possible correlation with lipid profile indicators (LDL-C, TG and HDL-C) among female centenarians in Hainan, China. Methods: A cross-section of complete sample study including 822 female centenarians was conducted from the China Hainan Centenarians Cohort Study (CHCCS) from June 2014 to December 2016. Barthel index was used to estimate ADL disability and multivariate logistic regression model was used to explore the relationship between lipid profile indicator and ADL disability. Results: A total of 822 female centenarians were recruited in Hainan province, and the median age was 102 (IQR: 101-104) years, and 244 (29.7%) centenarians had ADL disability. After adjustment, 1 mmol/L increment in LDL-C, TG and HDL-C were associated with 26.4% (aOR=0.736, 95% CI:0.592-0.915), 29.8% (aOR=0.702, 95% CI:0.521-0.948) and 60.5% (aOR=0.395, 95% CI:0.257-0.610) decline in ADL disability of female centenarian, respectively. The prevalence of ADL disability showed downward trend with the increase of the quintile of LDL-C, TG and HDL-C (P trend <0.05). Increment of HDL-C levels had the strongest protective effect against ADL disability. Conclusion: We concluded that a new possible association of higher normal lipid profile indicators, especially HDL-C, might have a protective effect on ADL disability among female centenarians.

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Impact of Renal Transplantation and Immunosuppressive Therapy on Muscle Strength, Functional Capacity, and Quality of Life: A Longitudinal Study

Gil

Lunardi

Santana

et al. 2020

Transplantation Proceedings

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The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults

Abstract: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.

Cited by 4 publications

References 46 publications

Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

<p>Higher Normal Levels of Triglyceride and Low and High-Density Lipoprotein Cholesterol Might Have a Protective Effect Against Activities of Daily Living Disability Within Chinese Female Centenarians: A Cross-Sectional, Complete Sample Study</p>

Impact of Renal Transplantation and Immunosuppressive Therapy on Muscle Strength, Functional Capacity, and Quality of Life: A Longitudinal Study

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