2011
DOI: 10.1038/jhh.2011.94
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The association between low 25-hydroxyvitamin D and increased aortic stiffness

Abstract: There is accumulating evidence that vitamin D exerts important pathophysiological effects on cardiovascular system. Low vitamin D was associated with increased cardiovascular risk in several reports. We studied the association between vitamin D and arterial stiffness in a random sample of 560 subjects selected from general population. Arterial stiffness was measured as aortic pulse-wave velocity (PWV) using Sphygmocor device. Serum 25-hydroxyvitamin D (25(OH)D) was measured using commercial kits. We found a cl… Show more

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Cited by 42 publications
(29 citation statements)
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“…In previous studies we have found that in the random, generally healthy population, the serum 25-OH-D 3 concentrations are inversely associated with aPWV [14]. Recently, we demonstrated similar findings for dp-ucMGP [15].…”
Section: Introductionsupporting
confidence: 79%
See 1 more Smart Citation
“…In previous studies we have found that in the random, generally healthy population, the serum 25-OH-D 3 concentrations are inversely associated with aPWV [14]. Recently, we demonstrated similar findings for dp-ucMGP [15].…”
Section: Introductionsupporting
confidence: 79%
“…In our previous analysis we found an independent inverse association between 25-OH-D 3 and increased arterial stiffness in the general population [14], and this finding was confirmed by several other studies in various settings of subjects [30][31][32][33]. The potential physiological role of vitamin D in regulating vascular calcification is multifactorial, but the pivotal role of matrix metalloproteinases (MMPs), a group of connective-tissue enzymes, is generally accepted.…”
Section: Accepted Manuscriptsupporting
confidence: 62%
“…Many observational studies have reported an inverse association between low VitD levels and brachial BP in large samples from the general population [23,24,25], but also among Peruvian adolescents [26], middle-aged individuals [27], people aged >60 years and the elderly [28,29], pregnant women and women aged 20-80 years [30,31]. Similarly, the evidence from medium to large observational studies shows strong and independent inverse associations between serum VitD and cfPWV among diverse study populations [32,33,34,35,36,37,38]. Other markers of regional arterial stiffness, including increased carotid-radial pulse wave velocity and brachial-ankle pulse wave velocity, have been associated with lower VitD levels among people with type 2 diabetes mellitus (T2DM) [39,40].…”
Section: Summary Of Observational Data On the Relationship Between Sementioning
confidence: 99%
“…Many cross-sectional studies have shown inverse associations between vitamin D and arterial stiffness (91,(101)(102)(103)(104)(105)(106)(107) , but there are relatively few clinical trials that have investigated the effect of vitamin D supplementation (Table 2). Gepner et al conducted a study in which healthy postmenopausal women were randomised to 62·5 μg vitamin D 3 daily (n 57) or placebo (n 57) for 4 months.…”
Section: Arterial Stiffnessmentioning
confidence: 99%