The association between lower urinary tract symptoms and sexual dysfunction: fact or fiction?

Dijk, Marleen van; Skrekas, Thomas; Rosette, Jean J.M.C.H. de la

doi:10.1097/00042307-200501000-00010

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…The lack of objective parameters of LUTS, such as uroflowmetry, is another limitation of this study, as we evaluated only the subjective parameter, IPSS. As LUTS and ED are believed to be linked, not only through pathological mechanisms but also in psychological aspects, 22 one hypothesis for interpreting these improvements is that the improved erectile function could have led to an improvement in the patient's quality of life, causing some confusion about the actual improvement of voiding symptoms. More evidence from clinical trials will be needed to clarify the relationships between the coadministration of both drugs and improvements in LUTS.…”

Section: Simultaneous Administration Of Udenafil and Anmentioning

confidence: 99%

Safety and efficacy of the simultaneous administration of udenafil and an α-blocker in men with erectile dysfunction concomitant with BPH/LUTS

Chung

Lee

et al. 2009

Int J Impot Res

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We evaluated the clinical efficacy and safety of administering udenafil (5-[2-propyloxy-5-(1-methyl-2-pyrollidinylethylamidosulphonyl)phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo(4,3-d)-pyrimidin-7-one) in patients with comorbid benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). One hundred and twenty patients who had been undergoing stable a-blocker therapy for BPH were enrolled in this trial and they were administered 100 mg udenafil for 8 weeks.Changes in blood pressure (BP), heart rate (HR), the international prostatic symptom score (IPSS) and the international index of ED (IIEF-5) were evaluated every 4 weeks. At end point, there was no significant change in BP and HR, whereas the lower urinary tract symptoms (LUTS) and ED improved significantly compared with baseline (IPSS 14.3-11.5, IIEF-5 11.95-18.32, Po0.05). Most patients were tolerant to the treatment and there was no evidence of additional side effects related to coadministration. The coadministration of udenafil and an a-blocker in patients with comorbid BPH and ED was safe and gave significant improvements in both LUTS and ED.

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Section: Simultaneous Administration Of Udenafil and Anmentioning

confidence: 99%

Safety and efficacy of the simultaneous administration of udenafil and an α-blocker in men with erectile dysfunction concomitant with BPH/LUTS

Chung

Lee

et al. 2009

Int J Impot Res

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“…Population surveys have shown high levels of sexual dysfunction in men over the age of 50 years [1,2]. Recent evidences from both community and clinical trials have suggested a link between lower urinary tract symptoms (LUTS) and sexual dysfunction [3][4][5]. Transurethral resection of prostate (TURP), the standard surgical therapy for the relief of LUTS, is reported to cause sexual dysfunction as well.…”

Section: Introductionmentioning

confidence: 99%

Erectile dysfunction after transurethral prostatectomy for lower urinary tract symptoms: results from a center with over 500 patients

Poulakis¹,

Ferakis²,

Witzsch³

et al. 2006

Asian J Andrology

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“…Considering LUTS among the 46 enrolled patients, 35 patients had severe symptoms (IPSS score 19-35), and the other 11 patents had moderate symptoms (IPSS score [8][9][10][11][12][13][14][15][16][17][18][19]. With regard to subjective erectile function, 21 of the 46 patients had severe erectile dysfunction (ED) (IIEF-5 score less than 8), 5 had moderate ED (IIEF-5 score 8~11), 19 had mild ED (IIEF-5 score 12~21), and 1 had normal erectile function (IIEF-5 score more than 21).…”

Section: Resultsmentioning

confidence: 99%

“…Several reports have suggested that BPH-related nocturia could be associated with erectile function [6,7], whereas there are opposite opinions [8,9]. With regard to the nocturia, nocturnal polyuria rather than benign prostatic obstruction (BPO) accounts for a greater proportion of nocturia [10].…”

Section: Introductionmentioning

confidence: 99%

Association between Nocturnal Frequency and Erectile Function in Eugonadal Men with Benign Prostatic Obstruction: A Cross Sectional Study

Lee

Kim

Sohn

2021

World J Mens Health

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Purpose: We aimed to evaluate the association between nocturnal frequency and erectile dysfunction in patients with benign prostatic obstruction. Materials and Methods: To evaluate the association, we simultaneous evaluated urodynamic study, prostate ultrasound, nocturnal tumescence test (nocturnal penile tumescence) for sleep-related erection (SRE) and two questionnaires, international prostate symptom score (IPSS) and 5-item version of the international index of erectile function (IIEF-5). Patients with hypogonadism or nocturnal polyuria were excluded. Results: Forty-six patients were registered over 4 years. The mean age, prostate size, IPSS score, and IIEF-5 score were 67.65±5.51 years, 65.10±22.12 mL, 24.67±7.89, and 9.50±7.01, respectively. Among the IPSS subscores, nocturia was most significantly related to the total IIEF-5 score (p<0.001). More severe nocturia was associated with less frequent SRE (p=0.003) and shorter total duration of SRE (p=0.002), which in turn elucidated that nocturia was significantly related to the total amount of rigidity signals (rigidity activity unit, RAU) or tumescence signals (tumescence activity unit, TAU). Among objective urodynamic parameters, bladder compliance also correlated to RAU and TAU. Individual subjective erectile function (IIEF-5) was significantly related to both RAU and TAU. Conclusions: Sleep fragmentation due to benign prostate obstruction related nocturnal frequency caused by reduced bladder compliance could decrease the frequency and duration of SRE, which decreases the total amount of SRE and reflects the patient's relevant erectile function.

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The association between lower urinary tract symptoms and sexual dysfunction: fact or fiction?

Cited by 8 publications

References 31 publications

Safety and efficacy of the simultaneous administration of udenafil and an α-blocker in men with erectile dysfunction concomitant with BPH/LUTS

Safety and efficacy of the simultaneous administration of udenafil and an α-blocker in men with erectile dysfunction concomitant with BPH/LUTS

Erectile dysfunction after transurethral prostatectomy for lower urinary tract symptoms: results from a center with over 500 patients

Association between Nocturnal Frequency and Erectile Function in Eugonadal Men with Benign Prostatic Obstruction: A Cross Sectional Study

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