The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up

Svensson, Thomas; Sawada, Norie; Mimura, Masaru; Nozaki, Shinichi; Shikimoto, Ryo; Tsugane, Shoichiro

doi:10.1038/s41398-018-0336-y

Cited by 65 publications

(70 citation statements)

References 46 publications

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“…No signi cant differences were found for other lipids and lipoproteins. These results agreed with those obtained by other authors [28,29], who found that cognitive dysfunction is associated with a progressive decline in plasma HDL-cholesterol concentrations This underscores the protective effects of increased plasma HDL-cholesterol and its role in maintaining superior cognition in longevity [30]. Biomarkers, cognitive status, and physical strength…”

Section: Biomarkers and Cognitive Statussupporting

confidence: 92%

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Pedrero‐Chamizo

Albers

Palacios

et al. 2020

Preprint

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Background Follow-up of vitamin B12 and lipids status is essential in older people, being closely related to non-communicable diseases. Their relationships with cognitive and physical status are not clear. The purpose of this study was to analyze the evolution of vitamin B12 and related parameters, lipid and hematological profiles, and their relationships with cognitive and physical status among institutionalized elderly. Methods Sixty residents (68% women), ranged from 62 to 99 years (mean age 85.1 ± 5.5 and 80.6 ± 9.9 years for women and men, respectively) were recruited from three nursing homes in Madrid Community (Spain). Biomarkers (vitamin B12 and related parameters, lipid and hematological profiles), functional capacity (handgrip, arm and leg strength), and cognitive status (Mini-Mental State Examination) were evaluated four times at 3-month intervals. Results At the beginning of the study, 63% and 70% of the sample showed abnormal homocysteine and folate values, respectively. At the end of the year, abnormal homocysteine increased to 68%, abnormal folate values decreased to 50%. Throughout the year, serum folate showed a significant increase (14.9 vs. 16.3 nmol/L), (p < 0.05). Serum cobalamin (299 vs. 273 pmol/L). HDL-cholesterol (49.9 vs. 47.0 mg/dL) and triglyceride levels (102.4 vs. 123.2 mg/dL) showed a significant decrease and increase respectively in mean values (all p < 0.05). Serum cobalamin and HDL-cholesterol were the most important biomarkers associated with cognitive function (both p < 0.05). The most relevant biomarkers associated with poor physical strength depending on the body part analyzed were low concentrations of HDL-cholesterol, LDL-cholesterol, apolipoprotein A1, and albumin (all p < 0.05). Conclusions The evolution of lipid biomarkers, their significance with cognitive values, and association with handgrip, point to the importance of the handgrip measurement, a very simple test, as an important health marker. Both serum albumin and physical strength are important health markers in older people.

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Section: Biomarkers and Cognitive Statussupporting

confidence: 92%

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Pedrero‐Chamizo

Albers

Palacios

et al. 2020

Preprint

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“…In particular, women showed a considerable increase in dementia after 60 years. In the same context, a recent study on the Japanese population showed that high midlife HDL-C levels are inversely associated with both late-life MCI and dementia [31]. Other studies with the American population also showed that higher HDL cholesterol levels are associated with better cognitive function [32].…”

Section: Discussionmentioning

confidence: 99%

Decrease in HDL-C is Associated with Age and Household Income in Adults from the Korean National Health and Nutrition Examination Survey 2017: Correlation Analysis of Low HDL-C and Poverty

Cho

Park

Kim

et al. 2019

IJERPH

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A low serum high-density lipoproteins-cholesterol (HDL-C) level is a risk factor of cardiovascular disease and dementia. On the other hand, no study has elucidated the correlation between household income and the HDL-C level in the adult population. In the present study, 5535 subjects (20–80 year-old individuals) were selected from the Korean national health and nutrition examination survey 2017 (KNHANES VII-2, n = 2469 men, n = 3066 women). They were classified into five levels of household income grades ranging from one (the lowest) to five (the highest). They were also classified according to the HDL-C level: category 1 (<40 mg/dL, n = 943), category 2 (40–49 mg/dL, n = 1764), category 3 (50–59 mg/dL, n = 1572), category 4 (60–69 mg/dL, n = 820), and category 5 (≥70 mg/dL, n = 436). Generally, in both genders, a higher HDL-C level is associated with a larger percentage of income grades 4 and 5. Moreover, the lowest HDL-C group showed the largest percentage of income grade 1. In both groups, a significant increase in the average income grade was associated with a concomitant increase in the HDL-C level (men, p = 0.03, women, p < 0.001). In the low HDL-C category, a lower income grade is associated directly with a lower HDL-C level, which suggests that poverty is associated directly with a low HDL-C. Women showed a 3.3-fold higher incidence of dementia than men did at later-life. The sharp decrease in HDL-C in the female group older than 50 was accompanied by a dramatic increase in the incidence of dementia. However, the male group showed a relatively mild decrease in the HDL-C level after mid-life and weak elevation in the incidence of dementia. In conclusion, in both genders, the lower income group showed a larger prevalence of low-HDL-C levels. The decrease in HDL-C after middle age was strongly associated with the considerable increase in dementia in later-life.

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“…Similar processes may drive the association detected here. With regard to lipd metabolism, it was showed previously that high levels of total cholesterol and low-density lipoprotein (LDL) cholesterol, were associated with cognitive decline in older population [44], and that low-level of high-density lipoprotein (HDL) cholesterol is a risk factor for deficit and decline in memory in midlife [67, 68]. HDL cholesterol is critical for the maturation of synapses and maintenance of synaptic plasticity while LDL cholesterol is a proven risk factor for cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load

Narbutas

Egroo

Chylinski

et al. 2019

Aging

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We investigated whether cognitive fitness in late midlife is associated with physiological and psychological factors linked to increased risk of age-related cognitive decline. Eighty-one healthy late middle-aged participants (mean age: 59.4 y; range: 50-69 y) were included. Cognitive fitness consisted of a composite score known to be sensitive to early subtle cognitive change. Lifestyle factors (referenced below as cognitive reserve factors; CRF) and affective state were determined through questionnaires, and sleep-wake quality was also assessed through actimetry. Allostatic load (AL) was determined through a large range of objective health measures. Generalized linear mixed models, controlling for sex and age, revealed that higher cognitive reserve and lower allostatic load are related to better cognitive efficiency. Crystallized intelligence, sympathetic nervous system functioning and lipid metabolism were the only sub-fields of CRF and AL to be significantly associated with cognition. These results show that previous lifestyle characteristics and current physiological status are simultaneously explaining variability in cognitive abilities in late midlife. Results further encourage early multimodal prevention programs acting on both of these modifiable factors to preserve cognition during the aging process.

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The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up

Cited by 65 publications

References 46 publications

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Decrease in HDL-C is Associated with Age and Household Income in Adults from the Korean National Health and Nutrition Examination Survey 2017: Correlation Analysis of Low HDL-C and Poverty

Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load

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