The association between neutrophil-to-lymphocyte ratio and post-stroke depression

Chen, Huijun; Luan, Xiaoqian; Zhao, Kai; Qiu, Huihua; Liu, Yuntao; Tu, Xinjie; Tang, Wenjie; He, Jincai

doi:10.1016/j.cca.2018.08.026

Cited by 39 publications

(50 citation statements)

References 44 publications

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“…12,13 Previous studies have been conducted to examine the relationship between NLR and depression after ischemic stroke. 14 However, the association of NLR and depression after ICH has not been clarified. Thus, this study aimed to investigate the predictive value of NLR in depression at 3 months after ICH.…”

Section: Introductionmentioning

confidence: 99%

Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage

Xiao

Feng

et al. 2020

NDT

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Inflammation plays a critical role in the development of depression after intracerebral hemorrhage (ICH), while neutrophil-to-lymphocyte ratio (NLR) has been identified as a novel comprehensive inflammatory indicator in recent years. The aim of this study was to examine the association between NLR and depression after ICH. Patients and Methods: From January 2016 to December 2018, ICH patients were prospectively enrolled. NLR was measured at admission. Depression at 3 months after ICH was diagnosed according to the Hamilton Depression Scale (HAMD). Results: Of the 372 enrolled patients, 107 (28.8%) were diagnosed with depression at 3 months after ICH. Patients with depression had a higher NLR (6.15 vs 3.55, P < 0.001). Logistic regression analysis detected that after adjusting for major confounders, NLR remained independently associated with depression after ICH (OR = 2.25, 95% CI: 1.45-3.49, P < 0.001). Moreover, NLR acted as the optimal variable for prediction, with the optimal predictive threshold of 4.53 in ROC analysis. Conclusion: Elevated NLR is associated with depression at 3 months after ICH, suggesting that NLR may be a significant biomarker to predict depression after ICH.

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Section: Introductionmentioning

confidence: 99%

Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage

Xiao

Feng

et al. 2020

NDT

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“…Microglial cells are thought to be the prime players of the CNS in its own immune and inflammatory responses while pro-apoptotic pathways are activated as a result of the inflammation [46]. While these processes are usually localized to the CNS, a systemic immune response is also manifested as evidenced by peripheral inflammatory biomarkers such as the neutrophil to lymphocyte ratio [47][48][49][50][51]. Using various depression scales such as HAM-D and Quick Inventory for Depression Symptomatology (QIDS), it has been demonstrated that a high NLR ratio on admission predicted PSD after one month [50,52].…”

Section: Ischaemic Cascade and Inflammationmentioning

confidence: 99%

Post Stroke Depression to be Expected

Wijeratne¹,

Sales²

2021

Preprint

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Ischemic Stroke precedes depression . Post Stroke Depression (PSD) is a major driver for poor recovery, negative quality of life, poor rehabilitation outcomes and poor functional ability. This systematic reviews confirmed the post stroke depression as the norm as complex ischemic cascade involve the bioenergetic failure, deranged iron homeostasis ( calcium influx, Na influx, potassium efflux etc) excitotoxicity, acidotoxicity,disruption of the blood brain barrier, cytokine mediated cytotoxicity, reactive oxygen mediated toxicity , activation of cyclooxygenase pathway and generation of toxic products, infiltration of immune mediated cells resulting the cell death and deranged neuronal networks in mood related brain regions. This review focus on the pathobiology of stroke in the context and make the argument that PSD is the norm after a stroke rather than the exception.

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“…27 And there are already many studies using 1 month as evaluation point for PSD. [28][29][30] A score of 0 to 7 is considered to be normal, while a score of ≥7 is indicative of depression. Patients with a HAMD score of ≥7 were evaluated using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) for the diagnosis of post-stroke depression by a neurologist/psychiatrist who was blind to the laboratory results of stroke patients.…”

Section: Assessmentmentioning

confidence: 99%

Post-Stroke Depression and Estimated Glomerular Filtration Rate: A Prospective Stroke Cohort

Lin

Luan

et al. 2020

NDT

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Post-stroke depression (PSD) is a frequent comorbidity in patients presenting with acute ischemic stroke. Impaired kidney function has been associated with depression in nonstroke subjects. We would like to evaluate whether the estimated glomerular filtration rate (eGFR) on admission is associated with the development of PSD. Patients and methods: Total of 268 patients with acute ischemic stroke were recruited and completed 1-month follow-up visit. eGFR was calculated from the serum creatinine value, race, age, and sex by using the chronic kidney disease epidemiology collaboration equation (CKD-EPI creatinine equation). The 17-item Hamilton Depression Scale was used to evaluate depression symptoms. Patients with a depression score of ≥7 were evaluated using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition, for diagnosing post-stroke depression at 1 month. Meanwhile, 114 normal control subjects were also recruited. Results: Ninety-three (34.7%) patients were diagnosed as having PSD at 1 month. There was a significant intergroup difference in eGFR levels within 24 hrs after admission (F=13.608, p<0.001). The levels of eGFR within 24 hrs after admission were significantly lower in both non-PSD patients and PSD patients than in normal controls. In logistic regression, the level of eGFR (<82mL/min/1.73m 2) was independently associated with increased risk of PSD even after adjusting for confounders (OR=2.328, 95% CI:1.092-4.965, p=0.029). Conclusion: Reduced eGFR was found to be correlated with the development of PSD and it suggests the need for greater attentions and potential interventions for depression in patients with stroke and with reduced eGFR.

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The association between neutrophil-to-lymphocyte ratio and post-stroke depression

Abstract: Increased NLRs at admission are found to be correlated with PSD and may add prognostic information for the early discovery of PSD.

Cited by 39 publications

References 44 publications

<p>Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage</p>

<p>Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage</p>

Post Stroke Depression to be Expected

<p>Post-Stroke Depression and Estimated Glomerular Filtration Rate: A Prospective Stroke Cohort</p>

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