The association between nonsteroidal anti-inflammatory drugs and skin cancer: Different responses in American and European populations

Ma, Yanxue; Yu, Piaojian; Lin, Shuhuang; Li, Qiqun; Fang, Zijing; Huang, Zunnan

doi:10.1016/j.phrs.2019.104499

Cited by 21 publications

(20 citation statements)

References 65 publications

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“…Conversely, anti-inflammatory therapy might decrease the risk of cancer. Several cohort studies have shown that patients who received anti-inflammatory therapy had a decreased risk of developing certain cancers [8][9][10]21]. The risk of breast cancer was also shown to decrease for women who regularly used aspirin or other NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the complexity of immunological stimulation, chronic inflammation is an important process in the oncogenesis of breast cancer [7]. Some studies have shown that the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer, breast cancer, and skin cancer [8][9][10][11]. Although the regular use of aspirin and other NSAIDs is reported to reduce the risk of breast cancer, one study found that low-dose aspirin was not associated with improved breast cancer prognosis [12].…”

Section: Introductionmentioning

confidence: 99%

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Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

et al. 2020

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Background and objectives: Breast cancer is a common cancer in women and has been the fourth leading cause of death in Taiwanese women. Risk factors for breast cancer include family history of breast cancer, genetic factors, and not breastfeeding. Several studies have reported an association between repeated inflammation at a young age, especially among lactating women, and cancer; however, the number of studies about the association of mastitis and breast cancer in nonlactating women is still limited. Therefore, the aim of this study was to determine the relationship between mastitis in women aged ≥40 years and breast cancer. Materials and Methods: This was a retrospective cohort study design. The data source was the Longitudinal Health Insurance Database 2010 (LHID 2010), comprising data collected by Taiwan’s National Health Insurance program. Cases of newly diagnosed mastitis in women aged ≥40 years (ICD-9-CM code = 611.0) were selected from the years 2010 to 2012. Women not diagnosed with mastitis were selected as the control group, and their data for the years 2009 to 2013 were obtained through the database. In addition, the non-mastitis group was matched 1:10 by age. Results: A total of 8634 participants were selected from the LHID 2010, which included 734 cases with mastitis and 7900 cases without mastitis. After adjustment for age, hypertension, hyperlipidemia, diabetes, hypothyroidism, and autoimmune diseases, the Cox proportional hazard model showed that patients with mastitis had a higher risk of breast cancer (aHR = 3.71, 95% CI = 1.9–7.02) compared with the non-mastitis group. The Kaplan–Meier curve also showed that women with mastitis had a higher risk of developing breast cancer. Conclusions: This study confirmed that women with mastitis have a higher risk of developing breast cancer. Therefore, women aged ≥40 years could reduce breast cancer risk by taking precautions to prevent mammary gland infection and mastitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

et al. 2020

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“…A meta-analysis including 17 studies found a RR of 0.93 (95% CI 0.87–0.99) for non-selective COX inhibitors and skin cancer overall [ 85 ]. Results were similar for BCC (RR 0.94, 95% CI 0.89–1.00) and SCC (RR 0.90, 95% CI 0.83–0.98).…”

Section: Resultsmentioning

confidence: 99%

“…Neither non-selective COX inhibitors nor selective COX-2 inhibitors was significantly associated with melanoma [ 85 ]. The RR was 0.96 (95% CI 0.84–1.09) for non-selective COX inhibitors based on 11 studies, and was 1.04 (95% CI 0.99–1.19) for selective COX-2 inhibitors based on four studies.…”

Section: Resultsmentioning

confidence: 99%

Photosensitizing Medications and Skin Cancer: A Comprehensive Review

George

Baranwal

Kang

et al. 2021

Cancers

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(1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of keratinocyte carcinoma (squamous cell carcinoma and basal cell carcinoma) and melanoma are summarized, for each PSM. (3) There are extensive reports on antihypertensives and statins relative to other PSMs, with positive and null findings, respectively. Fewer studies have explored amiodarone, metformin, antimicrobials and vemurafenib. No studies report on the individual skin cancer risks in glyburide, naproxen, piroxicam, chlorpromazine, thioridazine and nalidixic acid users. (4) The research gaps in understanding the relationship between PSMs and skin cancer outlined in this review should be prioritized because the US population is aging. Thus the number of patients prescribed PSMs is likely to continue to rise.

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“…Epidemiological [ 3 , 4 ], clinical [ 5 , 6 , 7 ] and animal studies [ 8 , 9 ] have shown that constitutive expression or overactivation of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes during carcinogenesis results in aberrant metabolism of arachidonic acid. The autocrine and paracrine role of prostaglandins and leukotrienes in tumour epithelial cell proliferation, apoptosis, migration and invasion have been reviewed by Wang and DuBois [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10

Da-Costa-Rocha

Prieto

2021

IJMS

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The constitutive expression or overactivation of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes results in aberrant metabolism of arachidonic acid and poor prognosis in melanoma. Our aim is to compare the in vitro effects of selective COX-1 (acetylsalicylic acid), COX-2 (meloxicam), 5-LOX (MK-886 and AA-861), 12-LOX (baicalein) and 15-LOX (PD-146176) inhibition in terms of proliferation (SRB assay), mitochondrial viability (MTT assay), caspase 3-7 activity (chemiluminescent assay), 2D antimigratory (scratch assay) and synthesis of eicosanoids (EIA) in the B16F10 cell line (single treatments). We also explore their combinatorial pharmacological space with dacarbazine and temozolomide (median effect method). Overall, our results with single treatments show a superior cytotoxic efficacy of selective LOX inhibitors over selective COX inhibitors against B16F10 cells. PD-146176 caused the strongest antiproliferation effect which was accompanied by cell cycle arrest in G1 phase and an >50-fold increase in caspases 3/7 activity. When the selected inhibitors are combined with the antineoplastic drugs, only meloxicam provides clear synergy, with LOX inhibitors mostly antagonizing. These apparent contradictions between single and combination treatments, together with some paradoxical effects observed in the biosynthesis of eicosanoids after FLAP inhibition in short term incubations, warrant further mechanistical in vitro and in vivo scrutiny.

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The association between nonsteroidal anti-inflammatory drugs and skin cancer: Different responses in American and European populations

Cited by 21 publications

References 65 publications

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

Photosensitizing Medications and Skin Cancer: A Comprehensive Review

In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10

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