“…Despite some findings showing mixed results or no support for negative affect-motivated use in adolescence (Crooke, Reid, Kauer, McKenzie, Hearps, Khor, et al, 2013; see Kassel et al, 2010, and Chassin, Ritter, Trim, & King, 2003, for reviews), some empirical evidence supports that self-medication can emerge as early as adolescence (e.g., Gottfredson & Hussong, 2011; Gould, Hussong, & Hersh, 2012; Hersh & Hussong, 2009; Hussong et al, 2008; Reimuller, Shadur, & Hussong, 2011; Stice, Kirz, & Borbely, 2002). Moreover, adolescence is a period during which youth are more vulnerable to increases in negative affect, but developmentally lack the neurobiological systems to appropriately regulate these changes in affect, leading them to seek maladaptive coping methods including substance use (Steinberg et al, 2006).…”