The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Lee, Ju Han; Kim, Younghye; Choi, Jung Woo; Kim, Young Sik

doi:10.1530/eje-12-0903

Cited by 282 publications

(330 citation statements)

References 41 publications

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“…Although it is not statistically significant, our study showed that, the TNM staging of PTC patients in HT group had a higher proportion of stage I than the PTC patients in non-HT group. These results were compatible with the literatüre and these results can be suggestive that the tumor's biological behavior is better in the case of HT or its due to the close follow-up of HT patients for thyroid disorders (3,6,9,14).…”

Section: Discussionsupporting

confidence: 90%

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Kutlutürk¹,

Ünal²,

Çetin³

2017

J Turgut Ozal Med Cent

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Aim: A positive correlation between Hashimoto's thyroiditis (HT) and papillary thyroid cancer (PTC) is determinated in studies based on histopathological examination of the thyroidectomy materials, but this correlation is not determinated in studies based on Fine Niddle Aspiration Biopsy (FNAB). In this study, the histopathologic results of bilateral total thyroidectomy (TT) specimens were studied for outcomes of PTC association with HT and its relationship with clinical and pathological prognostic factors. Material and Methods: Demographic data, thyroidectomy indications and pathology results of 568 patients with performed TT between April 2009 March 2016 were collected. PTC identified patients, were evaluated in terms of HT association. In these patients, the prognostic factors were evaluated according to coexistence of HT. Results: The average age of the patients was 48.9 years and M / F ratio was 1: 3.5. HT was detected in 36 patients and PTCin 121 patients by histopathological examinations. PTC incidence in HT group was higher than non-HT group. (p = 0.025). HT incidence in PTC group was higher than non-PTC group (p = 0.025).When compared in terms of demographic and prognostic data of PTC patiens,no statistically significant difference was detected between PTC with and without HT groups. Conclusion: PTC detection rate in patients with HT, who has indication for thyroidectomy is higher than non-HT patients. HT patients (especially female sex), should be followed closely, in terms of the development of malignant nodules.

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Section: Discussionsupporting

confidence: 90%

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Kutlutürk¹,

Ünal²,

Çetin³

2017

J Turgut Ozal Med Cent

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“…This wide distribution of coexisting CLT and PTC may at least in part be due to differences in histological examination and criteria of autoimmunity characterization, patient selection or indications for thyroidectomy, population background and, mainly, environmental factors (2). A recent meta-analysis demonstrated that the occurrence rate of CLT was 2.8 times higher in patients with PTC compared to patients with benign thyroid diseases (7) and 2.4 times higher in patients with PTC than in those with other histopathological types (7). Albeit indirectly, these results suggest that patients with CLT might well present a stronger predisposition toward the development of PTC.…”

Section: Introductionmentioning

confidence: 99%

Chronic lymphocytic thyroiditis is associated with invasive characteristics of differentiated thyroid carcinoma in children and adolescents

Iliadou

Effraimidis

Konstantinos

et al. 2015

European Journal of Endocrinology

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Background: The association between chronic lymphocytic thyroiditis (CLT) and thyroid cancer is an interesting topic. The aim of the present study was to evaluate if demographic and histological characteristics as well as the long-term outcome of thyroid cancer was different in children and adolescents with and without CLT. Methods: The medical records of children and adolescents (%21 years old) were reviewed. The following data were recorded: gender, year and age at diagnosis, family history of thyroid cancer, history of external radiation therapy, histological type (papillary and variants, follicular and variants), tumour size, multifocality, infiltration of thyroid parenchyma or surrounding soft tissues, vascular invasion, presence of lymph node and distant metastases. Information about the presence of TgAb and TPOAb was also collected. Results: One hundred eight children and adolescents (median age 19.0, interquartile range 4.0 years) were diagnosed with differentiated thyroid carcinoma (DTC); 31 patients (28.7%) presented histological characteristics compatible with CLT. Infiltration of thyroid parenchyma was more frequent in patients with CLT compared to patients without (74.2% vs 48.1% respectively, PZ0.024). Familial papillary thyroid carcinoma (PTC) was more frequent in patients with CLT compared to those without CLT (20.7% vs 2.8% respectively, PZ0.009). There was no better outcome with respect to the presence of CLT or not. Conclusions: Children and adolescents with CLT present more frequently familial PTC as well as thyroid cancer with invasive characteristics.

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“…Patients with high thyroglobulin levels may have had pathological conditions causing thyroglobulin elevation, such as chronic thyroiditis, as the background of resected thyroid glands. Lee et al (30) reported that papillary carcinoma was significantly associated with pathologically confirmed chronic thyroiditis. However, further studies are required in order to investigate this possibility.…”

Section: Calcification (+) Calcification (-) ------------------------mentioning

confidence: 99%

Clinicopathological characteristics of thyroid cancer misdiagnosed by fine needle aspiration

Maeda

Kutomi

Satomi

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Fine-needle aspiration (FNA) is commonly used as a preoperative assessment to diagnose thyroid cancer. However, misdiagnosis of malignancy by FNA is not rare, even if image examination suggests the possibility of thyroid cancer. In the present study, the clinicopathological factors of patients whose preoperative FNA examination had not led to a diagnosis of thyroid cancer were examined. In total, 125 patients with thyroid cancer who underwent FNA and surgery (total thyroidectomy, subtotal thyroidectomy or hemithyroidectomy) at the Department of Surgery, Surgical Oncology and Science of the Sapporo Medical University Hospital between 2006 and 2013 were retrospectively analyzed. The patients were divided into two groups: Group A, malignancy determined by FNA, and group B, no malignancy. The groups were then compared by gender, age, tumor size, stage, tumor stage, lymph node metastasis, histology, surgical procedure methods, presence or absence of calcification and thyroglobulin levels. The mean age of the patients in group A (5 males and 59 females) was 53.0 years. The mean age in group B (11 males and 49 females) was 54.2 years. The mean tumor size in both groups was 1.6 cm. The mean thyroglobulin levels were 82.7 ng/ml in Group A and 525.5 ng/ml in group B. There were also significant differences between the groups for tumor stage (P=0.046), histological type (P=0.024) and thyroglobulin levels (P=0.035). The results of the present study suggested that it may be difficult to diagnose thyroid cancer by FNA in cases with non-papillary carcinoma and higher thyroglobulin levels.

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The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Cited by 282 publications

References 41 publications

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Chronic lymphocytic thyroiditis is associated with invasive characteristics of differentiated thyroid carcinoma in children and adolescents

Clinicopathological characteristics of thyroid cancer misdiagnosed by fine needle aspiration

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