The Association Between Platelets/Lymphocyte Ratio and Premature Rupture of Membranes

Abstract

Objectives: Premature rupture of membrane (PROM) refers to the spontaneous rupture of fetal membranes prior to delivery and the initiation of the labor. In addition, the early rupture of membranes can lead to several adverse complications for both the mother and the fetus. Therefore, the present study aimed to investigate the association between the platelet-to-lymphocyte ratio (PLR) and the premature rupture of the membrane in pregnant women. Materials and Methods: This retrospective case-control study reviewed the files of 150 women with PROM matched with 150 spontaneous preterm labor (SPL) women at Al-Zahra hospital of Rasht during 2017-2018. Demographic data, complete blood cell count, PLR, maternal age, gestational week, gravida, parity, and birth weight were recorded, and finally, the obtained data were analyzed by SPSS, version 19. Results: Based on the results, there was a statistically significant difference between maternal platelet count and PLR in these two groups (P = 0.0001). However, no significant difference was observed regarding maternal age, gravida, parity, and maternal lymphocytes count in PROM and control groups (P > 0.05). According to logistic regression analysis, a negative association was found respecting gestational age and PLR in the PROM group while a positive association was observed in the group without PROM regarding birth weight and PRL. In the receiver-operator curve diagram, the appropriate cutoff point for the PLR index for detecting PROM was determined as 142.2 with a sensitivity of 62.7% and a specificity of 63.3%. Conclusions: In general, a significant association was found between PLR and PROM. Therefore, well-planned cohort studies are welcomed to find any prognostic role for this marker.

The Platelet-to-lymphocyte ratio, PELOD-2 score, and mortality rate in pediatric sepsis

“…More severe inflammation could lead to clinical deterioration, worse prognosis, and death. [7][8][9][22][23][24][25][26] Various studies had assessed PLR in septic patients, but the majority were conducted in adult populations. Very few studies were conducted in pediatric or neonatal populations, and many of them only assessed the usefulness of PLR in critically ill patients.…”

“…This parameter is as significant as other advanced and expensive inflammatory markers, such as interleukin (IL)-6, IL-8, IL-1b, and TNFa. [7][8][9] Although PLR has often been used for sepsis diagnosis and prognosis in neonates and adults, [7][8][9] it has not been widely studied in the older pediatric population. Therefore, we aimed to investigate the relationship between PLR, PELOD-2 score, and clinical outcomes in pediatric patients with sepsis.…”

Rasio platelet-limfosit serum ibu pada kehamilan preterm dan kehamilan preterm dengan Ketuban Pecah Dini (KPD): suatu studi potong-lintang

“…Sebuah studi oleh sebelumnya mendapatkan bahwa usia kehamilan memiliki korelasi negatif dengan kejadian KPD preterm yang berhubungan juga dengan nilai PLR. 14 Namun beberapa studi sebelumnya tidak didapatkan adanya perbedaan yang bermakna antara usia kehamilan dengan kejadian KPD preterm. 8, 13 Faktor risiko lain dari ketuban pecah dini preterm adalah nulipara.…”

“…24 Pada penelitian oleh Sharami SH et al dan Toprak E et al juga didapatkan hasil yang sejalan dengan penelitian ini, yaitu didapatkan peningkatan platelet dengan rerata 160,8 ± 34,3 (x 10 3 /µL) (p=0,0001) dan 244,5 ± 60.0 (x 10 3 /µL) (p<0,001) secara berturutturut pada kelompok KPD preterm. 8, 14 Hasil penelitian ini menunjukkan bahwa data rerata limfosit yang terjadi KPD preterm adalah 1,5 x 10 3 /µL sedangkan tanpa KPD didapatkan rerata jumlah limfositnya adalah 1,9 x 10 3 /µL. Kadar limfosit terendah yang ditemukan dalam penelitian ini adalah sebesar 0,7 x 10 3 /µL dan tertinggi 3,7 x 10 3 /µL.…”

“…Penelitian yang dilakukan sebelumnya menunjukkan tidak ada perbedaan yang bermakna antara penurunan jumlah limfosit pada pasien KPD preterm dengan rerata nilai limfosit sebesar 1,8 x 10 3 /mm 3 , 1,7 x 10 3 /mm 3 , dan 1,7 x 10 3 /mm 3 secara berturut-turut. 8,13, 14 Hasil uji analisis statistik menunjukkan perbedaan yang bermakna antara kadar PLR pada kelompok KPD preterm dengan kelompok tanpa KPD. Pasien dengan kadar PLR > 117 memiliki risiko 2,4 kali lebih besar untuk mengalami KPD preterm.…”