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IntroductionInsulin-like growth factor-binding protein 2 (IGFBP2) plays an important role in the pathogenesis of ovarian cancer. The most prominent effects of IGFBP2 include promoting proliferation, driving invasion, and suppressing apoptosis. This study aimed to determine the diagnostic accuracy of serum IGFBP2 in differentiating between benign and malignant ovarian neoplasms.MethodsPreoperative serum IGFBP2 level was evaluated from 76 women with primary ovarian tumor who underwent exploratory laparotomy at Sanglah General Hospital, Denpasar, Bali, Indonesia. The optimal threshold value of IGFBP2 for the diagnosis of ovarian cancer was determined from the receiver 0perating characteristic (ROC) curve. The diagnosis was confirmed by histopathologic analysis of resected ovarian specimens.ResultsForty-six (60.5%) patients were diagnosed with ovarian cancer. The area under the ROC curve (AUC) of IGFBP2 in detecting ovarian cancer was 0.815 (95% CI: 0.721 to 0.910, P<0.001). For a given specificity larger than 95%, the optimal sensitivity was 63%. The optimal threshold value of IGFBP2 for the diagnosis of ovarian cancer was 804 ng/mL [sensitivity 63%, specificity 96.7%, positive predictive value (PPV) 96.7%, negative predictive value (NPV) 63%, accuracy 76.3%, and diagnostic odd ratio (DOR) 49.5 (95% CI 6.1 to 396.5)]. In a subgroup analysis, IGFBP2 showed excellence performance in diagnosing advanced ovarian cancer (AUC 0.904 [95% CI: 0.806 to 1.000], sensitivity 83.3%, specificity 96.7%, PPV 95.2%, NPV 87.9%, accuracy 90.7%, and DOR 145.0 [95% CI 15.0 to 1395.3]).ConclusionIGFBP2 is a novel and potentially promising biomarker for detecting ovarian cancer. Further studies are needed to confirm its diagnostic performance in premenopausal women and for detecting early stage ovarian cancer.

Background: Hyperemesis gravidarum is severe and over vomiting suffered as of early in pregnancy until 20 weeks of gestation. It may be harmful to the mother's health that can lead to weight loss of more than 5% and cause metabolic disorders. If it does not get proper treatment, it affects complications, even maternal and fetal deaths. Aim: The study aims to generalize the characteristic of pregnant patients who suffered hyperemesis gravidarum in Sanglah General Hospital. Method: This study is a cross sectional retrospective descriptive study with data retrieval on patient records for one year in 2017. This research was conducted at Space Cempaka Obstetrics and Medical Record Division Sanglah Hospital Denpasar. Result and Conclusion:Pregnant women with hyperemesis gravidarum based on mother' s age is highest experienced by pregnant women in the age group 20-35 years as many as 6 people (75%). Based on maternal age, pregnant women with hyperemesis gravidarum is highest experienced by pregnant women in the first trimester as many as 5 people (62.5%). As regard with the parity, it was highest experienced by pregnant women in the parity group nullipara as many as 4 people (50%). Moreover, maternal education is highest academic of pregnant women who have junior high and high school education, each of them as many as 3 people (37.5%). Based on the job status is highest experienced by pregnant women who work as many as 5 people (62.5%).

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