The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

Abstract

Uric acid (UA) is a major antioxidant molecule and has been hypothesized to have a protective effect on the central nervous system against oxidative damage. We prospectively investigated the serum concentration of UA in primary angle closure glaucoma (PACG), and explored the association between serum concentration of UA and the severity of PACG. Using a retrospective case-control study design, 886 PACG subjects and 994 control subjects who attended the Eye & ENT Hospital of Fudan University, were eligible for this study. Glaucoma severity was classified as mild (MD ≤ 6.00 dB), moderate (12 dB ≥ MD > 6 dB) and severe (MD > 12 dB) based on the MD (mean deviation). The levels of UA were significantly lower (p = 0.025) in PACG (0.286 ± 0.082 mmol/l) compared with control (0.295 ± 0.085 mmol/l). The mean serum UA levels were lowest in the severe group (0.281 ± 0.074 mmol/l) followed by moderate (0.282 ± 0.080 mmol/l) and mild (0.297 ± 0.090 mmol/l) with significant differences among the three groups (p = 0.032). In multivariate regression analysis, there was a significant negative correlation between UA level and vertical cup-disc ratio (B = −0.165, p = 0.035). Significantly lower serum UA concentration in PACG and its negative association with disease severity presented it as an important candidate in reaction to oxidative stress in glaucoma pathogenesis.

Association of serum uric acid levels with primary open‐angle glaucoma: a 5‐year case–control study

“…Our previous study on UA levels in patients with primary angle closure glaucoma demonstrated that UA levels were reduced compared to those observed in normal controls, and that the level of UA was only negatively associated with the disease severity of primary angle closure glaucoma (Li et al. ). However, previous data regarding the serum levels of UA in patients with POAG are not available.…”

“…There is also evidence to suggest that oestrogen is a protective factor against POAG in females and can also influence the levels of UA in the body (Li et al. ,). Overall, the difference between the genders in terms of the association between UA levels and POAG severity may be explained by the differences in oestrogen levels between males and females.…”

“…Our previous study found significantly lower serum UA concentrations in primary angle closure glaucoma patients, and these were negatively associated with disease severity (Li et al. ). Beit‐Yannai et al.…”

“…; Li et al. ). The mean age of the participants in the POAG group was 49.99 ± 17.24 years (range, 18–86).…”

“…The detection methods used to calculate UA and Cr levels have previously been described in detail (Li et al. ). As we are aware, UA is also a biomarker of renal function, and thus, the UA/Cr ratio was used to reduce any possible interference in the interpretation of results caused by differences in renal function (Lolekha et al.…”