The association between severe or death COVID-19 and solid organ transplantation: A systematic review and meta-analysis

Ao, Guangyu; Wang, Yushu; X, Qi; Nasr, Basma; Bao, Mulong; Gao, Ming; Sun, Ying; Xie, Dan

doi:10.1016/j.trre.2021.100628

Cited by 51 publications

(44 citation statements)

References 46 publications

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“…SOT patients suffer from comorbidities such as chronic kidney disease and diabetes. Immunosuppressive drugs reduce hyper inflammation in SOT patients, but if infected with SARS-COV-2, risk bacterial and fungal co-infection as innate and adaptive immunity is compromised ( 84 ). Of the fundamental 5Cs that determine vaccine coverage, decreased confidence and medical mistrust correlated with the lack of research in SOT respondents ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine Hesitancy in the United States: A Systematic Review

Yasmin

Najeeb

Moeed

et al. 2021

Front. Public Health

257

199

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Vaccine hesitancy in the US throughout the pandemic has revealed inconsistent results. This systematic review has compared COVID-19 vaccine uptake across US and investigated predictors of vaccine hesitancy and acceptance across different groups. A search of PUBMED database was conducted till 17th July, 2021. Articles that met the inclusion criteria were screened and 65 studies were selected for a quantitative analysis. The overall vaccine acceptance rate ranged from 12 to 91.4%, the willingness of studies using the 10-point scale ranged from 3.58 to 5.12. Increased unwillingness toward COVID-19 vaccine and Black/African Americans were found to be correlated. Sex, race, age, education level, and income status were identified as determining factors of having a low or high COVID-19 vaccine uptake. A change in vaccine acceptance in the US population was observed in two studies, an increase of 10.8 and 7.4%, respectively, between 2020 and 2021. Our results confirm that hesitancy exists in the US population, highest in Black/African Americans, pregnant or breastfeeding women, and low in the male sex. It is imperative for regulatory bodies to acknowledge these statistics and consequently, exert efforts to mitigate the burden of unvaccinated individuals and revise vaccine delivery plans, according to different vulnerable subgroups, across the country.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine Hesitancy in the United States: A Systematic Review

Yasmin

Najeeb

Moeed

et al. 2021

Front. Public Health

257

199

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, only a previous meta-analysis comparing clinical outcome between SOT recipients and general population affected by COVID-19 currently exists [ 48 ]. Our findings are only partially consistent with those reported by Ao et al [ 48 ], considering that a slightly higher risk of mortality was found in SOT recipients in their pooled analysis of adjusted results. However, it is important to highlight that our meta-analysis included more than double the number of studies and participants (of which the number of SOT recipients was almost 4-fold greater) compared to the previous meta-analysis [ 48 ], thus providing an updated assessment of this issue.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

Gatti

Rinaldi

Bussini

et al. 2022

Clinical Microbiology and Infection

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“…Almost 2 years into the COVID‐19 pandemic, several studies indicate that solid organ transplant recipients (SOTRs) with COVID‐19 may have an increased risk of mortality 1‐3 . Studies from the general population have reported seroconversion in most subjects after SARS‐CoV‐2 infection 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls

Søfteland

Gisslén

Liljeqvist

et al. 2022

American Journal of Transplantation

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Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID‐19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti‐spike (S)‐ and anti‐nucleocapsid (N)‐specific IgG antibodies after COVID‐19 in SOTRs compared to matched immunocompetent persons. SOTRs (n = 65) were matched with controls (n = 65) for COVID‐19 disease severity, age, and sex in order of priority. Serum‐IgG antibodies against N and S antigens of SARS‐CoV‐2 were analyzed. At 1 and 9 months after COVID‐19, anti‐S‐IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti‐N‐IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti‐N‐IgG at all time points (1 month p = .007, 3 months p < .001, 6 months p = .019, and 9 months p = .021) but not anti‐S‐IgG at any time points. A mixed‐model analysis confirmed these findings except for anti‐S‐IgG at 1 month (p = .005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S‐specific, but not N‐specific, antibody responses to SARS‐CoV‐2 infection compared to immunocompetent controls.

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The association between severe or death COVID-19 and solid organ transplantation: A systematic review and meta-analysis

Cited by 51 publications

References 46 publications

COVID-19 Vaccine Hesitancy in the United States: A Systematic Review

COVID-19 Vaccine Hesitancy in the United States: A Systematic Review

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls

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