The association between sleep duration and dry eye syndrome among Korean adults

Lee, Wanhyung; Lim, Sung Shil; Won, Jong Uk; Roh, Jaehoon; Lee, June Hee; Seok, Hongdeok; Yoon, Jin Ha

doi:10.1016/j.sleep.2015.06.021

Cited by 53 publications

(50 citation statements)

References 36 publications

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“…Lee et al 49 reported survey results of sleep duration in 15,878 Korean participants divided into five groups according to habitual sleep duration (4, 5, 6-8, 9, and ‡10 hours), and demonstrated that the prevalence of DED was correlated with sleep duration, with an odds ratio (OR) for DED prevalence, after adjusting for age, sex, and sociodemographic factors (smoking habit, alcohol consumption, and level of exercise), of 1.30 for a short sleep (4 hours), 1.2 for 5 hours, 0.89 for 9 hours, and 1.0 for ‡ 10 hours, compared to optimal sleep (6-8 hours). They discussed the significant association of sleep deprivation with DED risk, in relation to increased inflammation by tear hyperosmolarity, androgen levels, the parasympathetic nervous system, and blinking.…”

Section: Sleep Disorders Are Prevalent and Severe In Dedmentioning

confidence: 99%

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Ayaki

Ohta

Kawashima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Sleep is an essential life habit and closely associated with lifespan, diabetes, hypertension, and mental health. Sleep disorders are a prominent, but overlooked problem in patients with dry eye disease (DED), characterized by a poor sleep index, short sleep duration, long sleep latency, and poor subjective sleep. DED and sleep disorders are more prevalent in women than men. Moreover, sleep quality in DED is worse than in other eye diseases, including glaucoma, retinal diseases, cataract, and allergic and chronic conjunctivitis. METHODS. We reviewed the literature for studies investigating sleep and health, eyes and sleep, and DED and sleep, in terms of systemic and eye health, especially in women. RESULTS. Two studies reported that approximately half of patients with DED suffer from poor sleep. The severity of mood disorders, including anxiety and depression, is correlated strongly with sleep disorders in DED, and the symptoms and signs of DED, especially pain, also are correlated with sleep quality. Sleep disorders are documented in primary Sjögren's syndrome and an association with sleep apnea and depression is suggested. Primary Sjögren's syndrome includes arthritis and other rheumatic disease causing pain and fatigue; however, how sicca contributes to sleep disorders is not known. CONCLUSIONS. Possible explanations for sleep disorders in DED may be depression, pain, and eye exposure at night. Reciprocal effects may be expected and consultation-liaison psychiatry is recommended for the management of sleep disorders in DED. Topical medication and lid heating also may be advantageous for sleep quality in DED.

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Section: Sleep Disorders Are Prevalent and Severe In Dedmentioning

confidence: 99%

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Ayaki

Ohta

Kawashima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…The results of several previous research works suggest a reciprocal relationship between DED and sleep disorders, particularly in elderly patients 18,39–43. A cross-sectional study including 187 veterans with mean age of 63 years demonstrated that the severity of dry eye symptoms was closely aligned with that of insomnia 18.…”

Section: Association With Psychiatric Problemsmentioning

confidence: 91%

“…Sleep deprivation may also be associated with increased risk of DED 43,44. A large population-based study in Korea revealed that short sleep duration of ≤5 hours/day was related to higher prevalence of DED 43.…”

Section: Association With Psychiatric Problemsmentioning

confidence: 99%

“…A large population-based study in Korea revealed that short sleep duration of ≤5 hours/day was related to higher prevalence of DED 43. An experimental study on human subjects demonstrated that sleep deprivation led to increased tear osmolarity, decreased tear secretion and shortened tear film breakup time, all of which can aggravate the symptoms and signs of DED 44…”

Section: Association With Psychiatric Problemsmentioning

confidence: 99%

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Association of dry eye disease with psychiatric or neurological disorders in elderly patients

Han

Yang²,

Hyon³

et al. 2017

CIA

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Dry eye disease (DED) is a common disease that can impair quality of life significantly. Its prevalence increases with advancing age, and the economic burden of the disease on both a patient and the society is increasing with elongation of life expectancy. The diagnosis and treatment of DED are often difficult due to the discordance between symptoms and signs of the disease. Recent studies have suggested the role of neurological or psychological factors in the development of dry eye symptoms and discrepancy of the symptoms and signs, particularly in elderly patients. In this review, the authors discuss the association of DED with various psychiatric and neurological disorders. In addition to psychiatric conditions, including depression, anxiety, stress, posttraumatic stress disorder and sleep disorders, medications for the psychiatric disorders have association with DED. Neurological disorders, such as neuropathic pain, chronic pain syndrome, peripheral neuropathy and several central nervous system disorders, are related to DED. Treatment of DED, combined with psychiatric or neurological disorders, is also discussed. Attention should be paid to the DED patients with discordant symptoms and signs, and unsatisfactory response to conventional treatment for associated psychiatric or neurological disorders, as well as an integrated treatment approach, could be helpful for these patients.

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“…Accompanying ocular signs include tear film instability, hyperosmolarity, inflammation, ocular surface damage, neurosensory abnormality, and dysfunction of the main lacrimal gland (LG). In 2015, Korean researchers published data from 15,878 adult subjects to assess the correlation between sleep duration and dry eye (Lee et al, 2015). The results indicated that a higher dry eye prevalence was present in groups with severe short sleep duration (< 4 h).…”

Section: Introductionmentioning

confidence: 99%

N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome

Chen

Zheng

et al. 2020

Front. Pharmacol.

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Sleep loss is a key factor associated with dry eye. Use of a "stick over water" mouse model revealed that sleep deprivation induces accumulation of lipids, hypertrophy, and dysfunction of the lacrimal gland. These changes result in decreased tear production and dry eye clinical signs. The specific pathophysiological mechanisms that contribute to dry eye remain unclear. In this study, we found that sleep deprivation decreased endogenous lipid palmitoylethanolamide (PEA) expression in the lacrimal gland. The reduced expression was mainly attributed to the decreased expression of N-acylated phosphatidylethanolamine-phospholipase D, the synthetic enzyme of PEA. Exogenous PEA treatment restored local lipid metabolism homeostasis in the lacrimal gland. This change was accompanied by reduced lipid deposition, maintenance of the endoplasmic reticulum and mitochondrial morphology, and improved acinar cell secretory function. PEA treatment also prevented damage to corneal barrier function and improved the dry eye clinical signs caused by sleep deprivation. The nuclear receptor peroxisome proliferator-activated receptor-a (PPAR-a) was found to mediate the PEA-associated improvements. We describe here for the first time that PEA is involved in sleep deprivation-induced lacrimal gland pathogenesis and dry eye development. PEA and its metabolizing enzymes may serve as adjunctive therapeutic targets for treatment of dry eye.

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The association between sleep duration and dry eye syndrome among Korean adults

Cited by 53 publications

References 36 publications

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Association of dry eye disease with psychiatric or neurological disorders in elderly patients

N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome

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