The association between the prognostic nutritional index and 28-day mortality among atrial fibrillation patients in China over 80 years of age

Cai, Jinming; Chen, Conggai; Zhang, Lingyun; Zhai, Xinrong; Zhao, Xiaona; Ge, Jin; Chang, Xifeng; Song, Bin; Qu, Xinkai

doi:10.1016/j.numecd.2022.03.013

Cited by 4 publications

(4 citation statements)

References 45 publications

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“…Serum albumin plays a significant role in maintaining human homeostasis, regulating colloid osmotic pressure, mediating inflammatory activity, and transporting different substances [27]. Previous studies demonstrated that albumin was involved in the process of preventing platelet aggregation and acted similarly to heparin [38].…”

Section: Discussionmentioning

confidence: 99%

“…For the purpose of determining whether the effects of RAR varied depending on various subgroups, stratification analyses were also carried out. Sex (male/female), hypertension (yes/no), diabetes (yes/no), coronary heart disease (yes/no), chronic heart failure (yes/no), cancer history (yes/no), renal failure (eGFR< 60 or ≥60 mL/min/1.73 m 2 ), FI-Lab (non-frail, prefrail, or frail), and the primary causes of hospitalization (AF, heart failure, AC, pneumonia, or other) were determined as stratification factors based on the potential clinical and biological effects of these covariates on the association between RAR and all-cause mortality in previous studies [16–18, 27]. R software (version 3.4.3) and EmpowerStats (http://www.empowerstats.com) were both utilized for all analyses.…”

Section: Methodsmentioning

confidence: 99%

“…When combined with the current data, these findings suggested that RDWassociated inflammation may be a significant contributor to unfavorable cardiovascular events. Serum albumin plays a significant role in maintaining human homeostasis, regulating colloid osmotic pressure, mediating inflammatory activity, and transporting different substances [27]. Previous studies demonstrated that albumin was involved in the process of preventing platelet aggregation and acted similarly to heparin [38].…”

Section: Relationship Between Rar and Atrial Fibrillationmentioning

confidence: 99%

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Relationship between the Ratio of Red Cell Distribution Width to Albumin and 28-Day Mortality among Chinese Patients over 80 Years with Atrial Fibrillation

Chen,

Cai,

Song

et al. 2023

Gerontology

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Introduction: Atrial fibrillation (AF) is a prevalent heart arrhythmia in elderly adults aged 80 years or older. The red cell distribution width to albumin ratio has been acknowledged as a reliable prognostic marker for poor outcomes in a variety of disorders. However, there exists limited scientific evidence on the association of red cell distribution width to albumin (RAR) with mortality in geriatric individuals with AF. Methods: From January 2015 to June 2020, a retrospective study was conducted in a tertiary academic institution that diagnosed 1141 elderly adults with atrial fibrillation (AF). The RAR value was calculated as the ratio of RDW (%) to albumin (g/dL). The potential association between RAR and cardiovascular mortality and the risk of all-cause mortality within 28 days was evaluated by means of multivariable Cox regression analysis. Results: The 28-day all-cause and cardiovascular mortality rates were 8.7% and 3.3%, respectively. Increased RAR tertiles were found to be significantly associated with greater all-cause mortality (T1: 1.6%; T2: 6.2%; T3: 18.1%, P < 0.001) and cardiovascular mortality (T1: 0.8%; T2: 2.9%; T3: 6.3%, P < 0.001) using Kaplan‒Meier analysis. Continuous RAR had a positive association with all-cause mortality (HR=1.42, 95% CI 1.23-1.65) and cardiovascular mortality (HR=1.31, 95% CI 1.05-1.64), even after accounting for numerous confounding variables. In comparison to the T1 group, individuals with the highest RAR levels displayed a greater risk of all-cause mortality (HR=2.73, 95% CI 1.11-6.74) and cardiovascular mortality (HR=2.59, 95% CI 0.69-9.78). Increased RAR levels were related to higher rates of cardiovascular and all-cause mortality across almost all subgroups. Conclusion: RAR is independently correlated with 28-day all-cause mortality and cardiovascular mortality in AF-affected individuals aged ≥ 80. Keywords: cardiovascular disease; mortality; older; red cell distribution width; atrial fibrillation

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Relationship Between Rar and Atrial Fibrillationmentioning

confidence: 99%

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Relationship between the Ratio of Red Cell Distribution Width to Albumin and 28-Day Mortality among Chinese Patients over 80 Years with Atrial Fibrillation

Chen,

Cai,

Song

et al. 2023

Gerontology

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“…9 Serum albumin exhibits diverse antithrombotic, antioxidant, and anti-inflammatory proeprties. 10 Given the key roles of these two physiological biomarkers, the neutrophil percentage-to-albumin ratio (NPAR) is frequently analyzed to glean relevant information about a variety of clinical conditions. Notably, the NPAR has been shown to be significantly linked to the severity of cardiovascular disease, stroke-related infection, pancreatic cancer, and kidney injury and to the prognosis of affected patients.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between the Neutrophil Percentage-to-Albumin Ratio and Rates of 28-Day Mortality in Atrial Fibrillation Patients 80 Years of Age or Older

Cai¹,

Li²,

Wang³

et al. 2023

JIR

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Atrial fibrillation (AF) is the most common cardiac arrhythmia among the older patients (≥ 80 years) in clinical practice. The index of neutrophil percentage-to-albumin ratio (NPAR) is a reliable predictor of adverse outcomes in cardiovascular diseases. There is scarce evidence regarding the association between NPAR and mortality among the older patients with AF. Methods: The research was conducted among 1141 patients with AF between January 2015 and June 2020, hospitalized at Huadong Hospital affiliated with Fudan University. The primary outcome were 28-day all-cause and cardiovascular mortality. Cox regression analysis and Kaplan-Meier survival curves were used to explore the correlation between NPAR and 28-day all-cause or cardiovascular mortality. Receiver operating characteristic (ROC) curve and the area under the curve (AUC) were performed for the predictive values of NPAR on prognosis. Results: The 28-day death rate from cardiovascular disease and all-causes were 3.3% and 8.7%, respectively. Continuous NPAR levels were positively associated with all-cause (HR 1.13, 95% CI 1.09, 1.16) and cardiovascular (HR 1.16, 95% CI 1.10, 1.23) mortality after adjustment for confounding variables. Relative to patients in the T1 group, those in higher NPAR tertiles also exhibit elevated risks of all-cause (P < 0.001) and cardiovascular mortality (P < 0.001). Furthermore, both all-cause and cardiovascular mortality rates rose with increasing NPAR in all analyzed subgroups. Conclusion: NPAR values are consistently positively related to 28-day all-cause and cardiovascular mortality rates in patients ≥80 years of age with AF.

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Prealbumin as a nutrition status indicator may be associated with outcomes of geriatric hip fractures: a propensity score matching and 1-year follow-up study

Liu

Yang

et al. 2022

Aging Clin Exp Res

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The association between the prognostic nutritional index and 28-day mortality among atrial fibrillation patients in China over 80 years of age

Cited by 4 publications

References 45 publications

Relationship between the Ratio of Red Cell Distribution Width to Albumin and 28-Day Mortality among Chinese Patients over 80 Years with Atrial Fibrillation

Relationship between the Ratio of Red Cell Distribution Width to Albumin and 28-Day Mortality among Chinese Patients over 80 Years with Atrial Fibrillation

The Relationship Between the Neutrophil Percentage-to-Albumin Ratio and Rates of 28-Day Mortality in Atrial Fibrillation Patients 80 Years of Age or Older

Prealbumin as a nutrition status indicator may be associated with outcomes of geriatric hip fractures: a propensity score matching and 1-year follow-up study

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