The association between the socioeconomic status and systemic comorbidities in patients with oral cancers: a retrospective study in Guangxi Province

Zhou, Zhuoqian; Tang, Qinchao; Chen, Xueru; Yu, Tao; Huang, Wanqian; Liang, Feixin

doi:10.1007/s00784-020-03405-2

Cited by 3 publications

(10 citation statements)

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“…Third, although BMI is considered as a good measure of assessing overweight and obesity in adults, waist circumference, hip circumference, total body fat, and visceral adipose tissue volume [ 49 ] are also recommended to assess overweight and obesity. Fourth, the number of overweight participants in our study was relatively small, however, the socioeconomic status of Guangxi province [ 18 ] and the evidence from previous study [ 50 ] showed that the proportion of overweight participants in our study was understandable. Lastly, previous studies showed that leukocyte TL was inversely associated with BMI in adulthood [ 51 ], and there was a strong correlation between newborn TL in cord blood and both parental TL [ 17 ].…”

Section: Discussionmentioning

confidence: 67%

“…Guangxi is the ninth largest province with over 49.2 million residents in southwestern China, however, the per capita Gross regional product (GRP) of Guangxi was only ranked 26th to 28th among China’s 31 provinces from 2003 to 2017 [ 18 ]. Data between June 2015 and May 2018 for this study were extracted from the Guangxi Zhuang Birth Cohort (GZBC), which was conducted in 6 county-level hospitals with visitors mainly from rural areas, and details on the ongoing GZBC have been introduced in our previous study [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

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Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China

Wei

Shao

Liang

et al. 2021

BMC Pregnancy Childbirth

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Background Telomere length (TL) is variable at birth and is inversely associated with body mass index (BMI) in adulthood. A growing number of evidences suggested that a higher maternal pre-pregnancy BMI results in adverse offspring health outcomes, especially shorter newborn TL. However, a newborn’s genetic endowment is equally derived from both parents, the association between parental pre-pregnancy BMI and newborn TL has been rarely discussed. We aimed to determine the association between parental pre-pregnancy BMI and newborn TL. Methods A total of 1082 parent-newborn pairs were recruited from the Guangxi Zhuang Birth Cohort (GZBC). TL in cord blood was measured using quantitative real-time polymerase chain reaction (qPCR) and expressed as the ratio of telomere copy number to single-copy gene number (T/S). A series of linear regressions were performed to assess the associations between parental pre-pregnancy BMI and newborn TL. Results Mothers who were overweight before pregnancy had significantly shorter cord blood telomere length in their newborns than those who were normal weight before pregnancy [percentage change: − 7.96% (95% CI: − 14.49 to − 0.69%; P = 0.032)]. Further analysis of the combined effects of parental weight status on newborn TL showed that TL was significantly shortened among newborns whose mothers were overweight and fathers were of healthy weight when compared with those whose mothers and fathers were both of normal weight [percentage change: − 8.38% (95% CI: − 15.47 to − 0.92%; P = 0.028)]. Subgroup analysis indicated these effects were more pronounced among male newborns and those whose paternal age < 31 years or maternal age ≥ 28 years at delivery. Conclusions Maternal pre-pregnancy overweight, but not paternal pre-pregnancy overweight is associated with shorter newborn TL. Weight control in reproductive women and effective healthy weight management before pregnancy may be of particular benefit for improving longevity and life quality of offspring.

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Section: Discussionmentioning

confidence: 67%

Section: Methodsmentioning

confidence: 99%

Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China

Wei

Shao

Liang

et al. 2021

BMC Pregnancy Childbirth

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“…On the one hand, long-term exposure of the elderly to various complex environments and risk behaviour factors leads to increased incidence of cancer [ 21 ]. On the other hand, the prevalence of systemic comorbidities in patients with OC increased from 0.820% (2003) to 32.302% (2017) with the development of the economy and society, causing an increased risk of death [ 22 ]. The highest morbidity and mortality of OC at the high HDI stage may be attributed to the accurate registration system for cancer [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Cancer Incidence, Mortality, and Mortality‐to‐Incidence Ratio Are Associated with Human Development Index in China, 1990–2019

Xie

Shang

2022

BioMed Research International

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The burden of oral cancer (OC) is closely related to economic development. We aimed to evaluate the burden of OC at different stages of economic development in China in terms of incidence, mortality, and mortality-to-incidence ratio (MIR) from 1990 to 2019. Data on cancer in China from 1990 to 2019 were obtained from the Global Burden of Disease 2019. Based on human development index (HDI), Chinese economic development was divided into three stages: low, medium, and high HDI stages. Mann–Whitney U -test was used to evaluate the differences in age-standardised incidence rates (ASIR), age-standardised mortality rates (ASMR), and MIR at various stages of HDI. Correlation and regression tests were conducted to examine the association amongst ASIR, ASMR, MIR, and HDI in OC. The estimated annual percentage changes (EAPCs) were calculated to assess the trend of ASIR, ASMR, and MIR. Significant differences were observed in terms of ASIR, ASMR, and MIR between groups ( P < 0.001 ). The values of both sexes in the low HDI stage were lower than those of the medium and high HDI stages, except for MIR, in which the low HDI stage was the highest ( P < 0.05 ). ASIR and ASMR of OC in males at the medium HDI stage showed the fastest growth rate with EAPC values of 5.64 (95% confidence interval, 95% CI, 5.20 to 6.08) and 4.42 (95% CI, 4.01 to 4.82), respectively. A strong positive correlation exists between HDI and ASIR ( r = 0.96 ) and ASMR ( r = 0.91 ) in both sexes from 1990 to 2019. During the high HDI stage, the ASIR and ASMR of OC were at a high level, but the ASIR halted the uptrend trend and ASMR showed a decreasing trend. Therefore, the HDI index has been positively correlated with the ASIR and ASMR of OC in China in the past 30 years, but this relationship may not be sustained as the economy develops. The health department should continue to allocate additional resources for the prevention and treatment of OC.

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“…108 Some authors have attempted to explore the association between OSCC and systemic alterations or systemic diseases, although the nature of this association is still unclear. 9 To the best of our knowledge, this is the first systematic review to characterize OSCC co-occurring in patients systemically compromised. We found some systemic alterations that probably predispose to OSCC onset, despite the moderate certainty of evidence.…”

Section: Certainty Of Evidencementioning

confidence: 99%

“…8 Patients with systemic diseases may have increased cancer development risk, including OSCC. 9 Fanconi's anemia (FA) and xeroderma pigmentosum (XP) are wellknown diseases that increase the risk for OSCC development. 7 In patients with FA, there is chromosomal instability, immunodeficiency, and failure in the DNA repair machinery, while patients with XD may present OSCC in the lower lip and tip of the tongue due to ultraviolet radiation (UV) from sunlight.…”

Section: Introductionmentioning

confidence: 99%

Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2022

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This study aimed to map systemic alterations predisposing to oral squamous cell carcinoma (OSCC) onset. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. Five databases were used to access (1) reports of OSCC co‐occurring in patients with systemic conditions, (2) prevalence of OSCC among these patients, and (3) clinicopathological profiles. Data from more than 1 million patients worldwide showed that Fanconi's anemia, xeroderma pigmentosum, dyskeratosis congenital, chronic fatigue syndrome, and patients post bone marrow transplantation (BMT) present increased risk for OSCC development. The overall prevalence of OSCC in syndromic patients and post‐BMT were 0.65% (95% CI = 0.13–3.11, p < 0.01) and 5.83% (95% CI = 0.00–30.90, p < 0.01), respectively. The certainty of the evidence was moderate. This study demonstrated that some systemic conditions predispose to OSCC. These results present an impact on the screening of OSCC in systemically compromised patients.

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The association between the socioeconomic status and systemic comorbidities in patients with oral cancers: a retrospective study in Guangxi Province

Cited by 3 publications

References 20 publications

Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China

Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China

Oral Cancer Incidence, Mortality, and Mortality‐to‐Incidence Ratio Are Associated with Human Development Index in China, 1990–2019

Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

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