The association between trauma and melanoma in the Chinese population: a retrospective study

Zhang, N.; Wang, L.; Zhu, Guannan; Sun, Dongjie; He, Hong; Luan, Qi; Liu, L.; Fei, Hao; Li, C.Y.; Gao, Tianwen

doi:10.1111/jdv.12141

Cited by 36 publications

(32 citation statements)

References 22 publications

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“…Therefore, moles in the plantar weight-bearing area should be removed to avoid cancerous changes. Secondly, traumatic stimuli [12], such as excision misdiagnosed as "corns" or local ulceration caused by repeated friction, are the main factors to induce malignant tumors. About 40% of patients had "negligence" of the disease.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of acral melanoma that happened on foot

Yao

Cai

Wang

et al. 2020

Preprint

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Methods: The aim was to investigate the epidemiological, clinical, and prognostic features of acral melanoma (AM) that occurred on foot, and to provide associated data for further study. A retrospective study was performed on patients with malignant melanoma (MM) who were treated in our hospital from January 2015 to January 2019. The tumor site was screened by foot. Basic data (e.g., gender, age, occupation, tumor location and etiology) of eligible patients, tumor-related data (such as tumor thickness, lymph node metastasis, and systemic metastasis), surgical related data (e.g., surgical site, operation time, bleeding volume, postoperative drainage time and volume), and prognostic data (including local recurrence or metastasis) were extracted. Survival analysis was used to study event-free survival (EFS) and overall survival (OS) and factors influencing survival of patients. Results: A total of 109 patients with AM happened on foot, including 52 males and 57 females, male/female = 0.91, were involved. The patients’ age was 58.31±12.13 years old. The occupations included 69 (63.3%) of farmers, 20 (18.3%) of freelance work, 4, 10 and 6 (18.4% in total) of others, including workers, students, and retirees. Tumor locations were 19 (17.4%) of the thumbs, 9 (8.3%) of other toes, 54 (49.5%) of the inner and outer soles, 20 (18.3%) of the heels, and 7 (6.4%) of the back foot. The causes were 57 cases (52.3%) of malignant nevus, 7 cases (6.4%) of trauma stimulation, and 45 cases (41.3%) without inducement. Additionally, 29 cases (26.6%) were newly diagnosed and treated in our hospital, and 80 cases (73.4%) were previously treated in external hospitals. Symptoms of nudes or ulceration lasted for 1 to 15 months, with an average of 5.92 months. The main surgical methods are tumor (enlarged) resection, lymph nodes resection, and combined resection of tumor and lymph nodes. During the treatment, 45 patients needed additional surgery. At the last follow-up, 8 cases had tumor recurrence, 43 cases had lymph node metastasis, 29 patients (stage IV) had metastasis in vital viscera, and 12 patients died. The EFS was 16 months, and OS was 31 months on average. Univariate analysis suggested that there was a correlation between occupations and EFS, locations and OS. Conclusions: Middle-aged and elderly manual workers were found as the main population of AM that happened on foot. The tumor appeared at the weight-bearing area of the soles and heels. The proportion of metastasis was high, while the prognosis was poor. Preventive resection of precancerous lesions and early diagnosis and treatment of tumors are the primary tasks to improve the efficacy and survival of patients

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Section: Discussionmentioning

confidence: 99%

A retrospective study of acral melanoma that happened on foot

Yao

Cai

Wang

et al. 2020

Preprint

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“…Because the sites of predilection for ALM are mainly unexposed to the sun, ultraviolet radiation seemingly does not play an important role in the occurrence of ALM. Trauma, pressure and distinct gene mutations have been hypothesized to promote development of ALM. Interestingly, the incidence rate of ALM shows only few ethnic differences and is in the range of 0·4–0·8 cases per 100 000 inhabitants a year.…”

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confidence: 99%

Acral lentiginous melanoma: a skin cancer with unfavourable prognostic features. A study of the German central malignant melanoma registry (CMMR) in 2050 patients

et al. 2017

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SummaryBackground Acral lentiginous melanoma (ALM) is one of the four major subtypes in cutaneous melanoma (CM). Although ALM has a poorer prognosis than other CM subtypes, the prognostic factors associated with ALM have only been verified in small-sized cohorts because of the low incidence of ALM worldwide. Objectives To investigate the clinical characteristics of ALM and to evaluate their prognostic values based on a large dataset from the Central Malignant Melanoma Registry (CMMR) of the German Dermatologic Society. Methods The Kaplan-Meier method was used to estimate the potential influence of clinical and histological parameters on ALM disease-specific survival (DSS) curves, which were compared using the log-rank test. A Cox proportional hazards model was used to identify independent prognostic factors for DSS. Results In total, 2050 patients with ALM were identified from 58 949 patients with CM recorded by the CMMR with follow-up data. In multivariate analyses, age (P = 0Á006), ulceration (P = 0Á013), tumour thickness (P < 0Á001) and tumour spread (P < 0Á001) turned out to be significant prognostic factors for DSS in ALM whereas sex, nevus association and level of invasion were not independent factors. Conclusions ALM has the same prognostic factors as other subtypes of melanoma. Unfavourable prognosis probably derives from the delay in diagnosis in comparison with other melanoma subtypes.

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“…Most of available papers have not established any relationship between single or recurrent/persistent traumatic events and melanoma development [5, 6, 8, 12, 13, 15, 17]. Only few reports were published supporting such an association [34, 35]. It seems likely that patients might ascribe melanoma to former trauma incidents, which could facilitate the discovery of this malignancy.…”

Section: Discussionmentioning

confidence: 99%

“Better do not touch” and other superstitions concerning melanoma: the cross-sectional web-based survey

Gajda¹,

Kamińska‐Winciorek²,

Wydmański³

et al. 2016

pdia

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IntroductionTo the authors’ best knowledge, there are no data regarding the prevalence of superstitions concerning melanoma among internet users.AimTo evaluate the prevalence and identify reasons for superstitions associated with excision of pigmented skin lesions as well as to assess the frequency of this procedure.Material and methodsReaders of the scientific portal were invited to complete a fully anonymous e-questionnaire. After collection of questionnaires (5,154) and eliminating incomplete ones, 4,919 surveys were analysed.ResultsA total of 4,104 (83.4%) respondents have been aware that the total surgical excision is the only efficient way of melanoma treatment. This familiarity was related to increased skin cancer awareness but was not linked to regular skin self-examination. Over half of the surveyed agreed that “it is better not to touch naevi”. Moreover, 3,510 (71.3%) individuals believed that naevi located in “harmed places” may turn into melanoma.ConclusionsSuperstitions associated with surgical treatment of melanoma are widespread. Conducting educational campaigns is necessary, particularly among young people, whose dangerous tanning behaviours are important risk factors for melanoma occurrence in their later life.

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The association between trauma and melanoma in the Chinese population: a retrospective study

Abstract: Our findings provide epidemiological evidence for a potential association between traumatic events and melanoma of the extremities, especially the lower limbs, where a history of trauma is more likely.

Cited by 36 publications

References 22 publications

A retrospective study of acral melanoma that happened on foot

A retrospective study of acral melanoma that happened on foot

Acral lentiginous melanoma: a skin cancer with unfavourable prognostic features. A study of the German central malignant melanoma registry (CMMR) in 2050 patients

“Better do not touch” and other superstitions concerning melanoma: the cross-sectional web-based survey

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