The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS)

Tsuji, Mayumi; Shibata, Eiji; Morokuma, Seiichi; Tanaka, Rie; Senju, Ayako; Araki, Shunsuke; Sanefuji, Masafumi; Koriyama, Chihaya; Yamamoto, Megumi; Ishihara, Yasuhiro; Kawamoto, Toshihiro; Saito, Hirohisa; Kishi, Reiko; Yaegashi, Nobuo; Hashimoto, Koichi; Mori, Chisato; Ito, Shuichi; Yamagata, Zentaro; Inadera, Hidekuni; Kamijima, Michihiro; Nakayama, Takeo; Iso, Hiroyasu; Shima, Masayuki; Hirooka, Yasuaki; Suganuma, Narufumi; Kusuhara, Koichi; Katoh, Takahiko

doi:10.1016/j.envres.2018.06.025

Cited by 68 publications

(33 citation statements)

References 39 publications

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“…However, regardless of year of intensive research, the roles of Se, GPx, and selenoproteins are poorly understood in prematurity as well as oxidant injury [ 21 ]. In order to clearly be able to claim the role of trace elements in pre-term birth, roles of heavy metals should additionally be evaluated such as cadmium (Cd), which was found to be positively associated with the risk of early pre-term birth [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Low Selenium Levels in Amniotic Fluid Correlate with Small-For-Gestational Age Newborns

2020

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Background: Identifying women at risk for small-for-gestational-age newborns (SGA) is an important challenge in obstetrics. Several different risk factors have been suggested to contribute to the development of SGA. Previous research is inconclusive on the role selenium (Se) plays in the development of SGA. The aim of the study was therefore to explore the role of Se concentrations in amniotic fluid in order to understand its possible role in the development of SGA. Study Design: This prospective, single center study investigated the relationships between Se concentrations in amniotic fluid and pregnancy outcomes. Amniotic fluid was collected from pregnant women during amniocentesis at 16/17 weeks of pregnancy. Se values were determined using the electrothermal atomic absorption spectrometry and expressed in µg/L. Characteristics of mothers and newborns were obtained from women and delivery records. Results: 327 samples of amniotic fluid were evaluated. Patients with SGA newborns had significantly lower mean values of amniotic fluid concentrations of Se compared to appropriate-for-gestational-age (AGA) newborns (4.8 ± 1.9 µg/L versus 5.6 ± 2.5 µg/L (p = 0.017)). Adjusting for different risk factors, Se remained the only significant factor impacting the outcome of a newborn (b = −0.152, s.e. = 0.077; p < 0.048). Se levels in amniotic fluid did not correlate with pre-eclampsia or preterm delivery. Conclusion: Amniotic fluid Se levels represent a viable root of further investigation and assessment in order to identify women with low birth weight newborns early. Women with decreased Se levels had a statistically significant chance of developing SGA. Further research is needed to elucidate the link between Se, other trace elements, and other risk factors and their impact on the development of SGA newborns.

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Section: Discussionmentioning

confidence: 99%

Low Selenium Levels in Amniotic Fluid Correlate with Small-For-Gestational Age Newborns

2020

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“…We measured the metal concentrations in the blood according to our previous report [33]. Briefly, blood samples with sodium ethylenediaminetetraacetic acid (EDTA) were transferred to a central laboratory and stored at − 80 °C before use.…”

Section: Methodsmentioning

confidence: 99%

Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)

Tsuji

Shibata

Askew

et al. 2019

Environ Health Prev Med

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Background Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta. Methods We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations. Results The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb. Conclusion Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities. Electronic supplementary material The online version of this article (10.1186/s12199-019-0795-7) contains supplementary material, which is available to authorized users.

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“…In Korea, a recent research pointed out the risk of high Hg exposure as a particular environmental health issue for pregnant women [6]. A study in Japan demonstrated that high maternal blood Cd concentration was significantly associated with negative pregnancy outcomes [7]. A relatively high blood As concentration (median 11 μg/L) was found among Argentinian pregnant women [8].…”

Section: Introductionmentioning

confidence: 99%

Blood heavy metals and brain-derived neurotrophic factor in the first trimester of pregnancy among migrant workers

Zaw

Taneepanichskul

2019

PLoS ONE

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Background Lead, mercury, cadmium and arsenic are the priority heavy metals of major public health concern in industrialized countries. Exposure to them can cause cognitive impairment and depressive disorders through an effect on Brain-derived neurotrophic factor (BDNF) which is an important biomarker of pregnancy. Despite a number of prior studies on heavy metals pollution, there is few of studies on the effect of heavy metals on BDNF during early pregnancy. This study aims to examine the association between maternal blood heavy metals concentrations and BDNF during the first trimester pregnancy among Myanmar migrants in Thailand. Methodology This cross sectional study, a part of ongoing birth cohort was conducted at the antenatal care clinic from June to October 2018. A total of 108 with Myanmar migrant pregnancy with a single viable fetus of 0 to 14 gestation weeks who stayed within the industrial plant at least 3 months before were recruited. Socio-demographic characteristics and health behaviors were accessed using a self-report questionnaire. Maternal blood heavy metals (lead (Pb), mercury (Hg), cadmium (Cd) and arsenic (As)) were measured using an inductively coupled plasma mass spectrometer and plasma BDNF was measured using an enzyme-linked immunosorbent assay. Multivariate binary logistic regression were modeled to access the association. Results Median (interquartile rank: IQR) concentrations were: BDNF (6.49 (1.79) μg/ml), Pb (2.77 (1.46) μg/dL), Hg (0.62 (0.54) μg/dL), Cd (0.93(0.86) μg/L) and As (0.40 (0.11) μg/dL) respectively. We categorized BDNF concentrations into high (> median) (n = 54) and low (≤ median) (n = 54) groups. After adjusting for potential confounders, high blood total arsenic concentration had 2.6-fold increased odds (aOR = 2.603, 95% CI: 1.178, 5.751) of low plasma BDNF level as compared with low blood total arsenic group. However, there was no significant association between BDNF and Pb, Hg and Cd. Conclusions The present findings demonstrate higher blood total arsenic level were more likely to have lower BDNF in early pregnancy. Our study suggested that heavy metal could be worsen BDNF level which plays its important role on biological effect of maternal depressive disorder and newborn neurodevelopment.

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The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS)

Cited by 68 publications

References 39 publications

Low Selenium Levels in Amniotic Fluid Correlate with Small-For-Gestational Age Newborns

Low Selenium Levels in Amniotic Fluid Correlate with Small-For-Gestational Age Newborns

Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)

Blood heavy metals and brain-derived neurotrophic factor in the first trimester of pregnancy among migrant workers

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