The association of alcohol consumption with outcome of pregnancy.

Marbury, Marian C.; Linn, Shai; Monson, RichardR.; Schoenbaum, Stephen C.; Stubblefield, Phillip G.; Ryan, Kenneth J.

doi:10.2105/ajph.73.10.1165

Cited by 139 publications

(48 citation statements)

References 13 publications

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“…The lack of adverse outcomes due to consumption up to moderate levels is consistent with several previous studies of effects on either weight or HC in children ranging from birth to 24 months [9,12,24,[30][31][32][33][34][35][36][37][38][39][40][41][42]. One study that measured children at birth and then again at 6 years also found no effects associated with measures of actual alcohol consumption, although reduced HC and length were associated with a measure of indications of problem drinking [24,51].…”

Section: Discussionsupporting

confidence: 87%

“…In contrast, a number of studies have found no deleterious effects on one or more of these growth parameters at birth [9,12,24,[30][31][32][33][34][35][36][37][38][39][40][41][42], at 12 months [12,41], 24 months [12], and at 4, 7, and 14 years [42]. The different findings between studies reflect a number of factors such as the duration and amount of alcohol use among different samples with findings for moderate levels of alcohol exposure being more inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Maternal alcohol consumption during pregnancy and physical outcomes up to 5 years of age: a longitudinal study

O’Callaghan

Najman

et al. 2003

Early Human Development

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Aim: To examine whether alcohol exposure in pregnancy affects weight and head circumference (HC) at birth and 5 years, and whether these effects are independent of cigarette exposure in pregnancy and social disadvantage.Study design: The Mater-University Study of Pregnancy (MUSP) involves a prospective cohort of 8556 mothers who were enrolled at first antenatal visit. The quantity and frequency of alcohol consumption in early and late pregnancy and a measure of binge drinking in early pregnancy were recorded. Weight and HC were measured on children seen at birth and at 5 years. Level of cigarette use in early pregnancy and maternal age and level of education and family income were also measured.Results: Light and moderate alcohol consumption in early or later pregnancy had no independent effects on weight or HC at birth or 5 years. Binge drinking in early pregnancy was not associated with restricted HC, and there was no effect modification by concurrent cigarette use in early pregnancy. An apparent effect of alcohol in late pregnancy on birth weight was due to confounding by cigarette use, with social risk being an independent predictor. Conclusion:Alcohol ingestion up to moderate levels in pregnancy was not associated with deficits in either weight or HC at birth or at 5 years.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Maternal alcohol consumption during pregnancy and physical outcomes up to 5 years of age: a longitudinal study

O’Callaghan

Najman

et al. 2003

Early Human Development

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“…Some recent epidemiological studies have clarified that maternal lifestyles, such as smoking or drinking habits and passive smoking during pregnancy, provoke some congenital anomalies (Jones and Smith, 1973;Himmelberger et al, 1978;Ericson et al, 1979;Kuroki, 1988;Jacobson et al, 1993;Yuan et al, 1994), although there are negative reports (Borlee et al, 1978;Marbury et al, 1983;Pradat, 1992). However, to our knowledge, an association of anal atresia with smoking and/or drinking during pregnancy has not been previously reported.…”

Section: Discussionmentioning

confidence: 84%

Anal atresia: Effect of smoking and drinking habits during pregnancy

1995

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SummaryUsing data compiled from 216,707 births from the population-based Kanagawa Birth Defects Monitoring Program (KAMP), we conducted a case-control study to evaluate the effect of maternal smoking and/or drinking during pregnancy on the risk of infants' anal atresia in 1989-1994. The frequency of maternal smoking (including passive smoking) and/or maternal drinking during pregnancy among 84 infants with anal atresia was compared with 174 matched controls. The 84 anal atresias include 49 cases of isolated anal atresia and 35 cases of syndromal anal atresia. Our findings suggest that maternal drinking during early pregnancy is associated with an increased risk of isolated anal atresia (OR=4.8, 95~ CI 1.2 to 19.1, p<0.05). A slightly increased trend was also observed in the association of maternal smoking during pregnancy with both in the pooled groups of anal atresia (OR= 1.4, 95 ~ CI 0.5 to 3.6).

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“…187 Spontaneous Abortion. Rates of spontaneous abortion and stillbirth, often due to placental abruption, are increased among women who drink more than 2 drinks daily according to prospective cohort studies, [188][189][190][191] a retrospective cohort study, 192 and a case-control study. 193 This association has also been suggested by retrospective surveys of women from the U.S. general population 178 and obstetric populations, 192,194 although these studies do not adequately control for the increased gravidity observed among heavy-drinking women.…”

Section: Alcohol-related Consequences Unique To Womenmentioning

confidence: 99%

“…Rates of spontaneous abortion and stillbirth, often due to placental abruption, are increased among women who drink more than 2 drinks daily according to prospective cohort studies, [188][189][190][191] a retrospective cohort study, 192 and a case-control study. 193 This association has also been suggested by retrospective surveys of women from the U.S. general population 178 and obstetric populations, 192,194 although these studies do not adequately control for the increased gravidity observed among heavy-drinking women. Studies that have failed to demonstrate a relation between heavy alcohol consumption and spontaneous abortion may have been limited by retrospective designs, insufficient power, [195][196][197][198][199][200] or use of inadequate measures of alcohol consumption.…”

Section: Alcohol-related Consequences Unique To Womenmentioning

confidence: 99%

Medical risks for women who drink alcohol

et al. 1998

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OBJECTIVE:To summarize for clinicians recent epidemiologic evidence regarding medical risks of alcohol use for women.METHODS: MEDLINE and PsychINFO, 1990 through 1996, were searched using key words "women" or "woman," and "alcohol." MEDLINE was also searched for other specific topics and authors from 1980 through 1996. Data were extracted and reviewed regarding levels of alcohol consumption associated with mortality, cardiovascular disease, alcoholrelated liver disease, injury, osteoporosis, neurologic symptoms, psychiatric comorbidity, fetal alcohol syndrome, spontaneous abortion, infertility, menstrual symptoms, breast cancer, and gynecologic malignancies. Gender-specific data from cohort studies of general population or large clinical samples are primarily reviewed. MAIN RESULTS:Women develop many alcohol-related medical problems at lower levels of consumption than men, probably reflecting women's lower total body water, gender differences in alcohol metabolism, and effects of alcohol on postmenopausal estrogen levels. Mortality and breast cancer are increased in women who report drinking more than two drinks daily. Higher levels of alcohol consumption by women are associated with increased menstrual symptoms, hypertension, and stroke. Women who drink heavily also appear to have increased infertility and spontaneous abortion. Adverse fetal effects occur after variable amounts of alcohol consumption, making any alcohol use during pregnancy potentially harmful. CONCLUSIONS:In general, advising nonpregnant women who drink alcohol to have fewer than two drinks daily is strongly supported by the epidemiologic literature, although specific recommendations for a particular woman should depend on her medical history and risk factors. L ess than three quarters of women in the UnitedStates drink alcohol, and those who do drink consume fewer drinks and less absolute alcohol than men. 1 However, at similar levels of self-reported alcohol consumption, the risk of psychosocial problems or dependence is greater for women than men (for definitions, see Appendix A). [2][3][4][5][6] Women also appear to develop alcohol abuse and dependence after fewer years of drinking than men. 7 Although only 4% to 5% of women in the U.S. general population meet criteria for past-year alcohol abuse or dependence, 8,9 9% of female primary care patients in some studies have reported recent heavy drinking or alcohol-related problems. 10,11 Many heavy drinkers decrease consumption following brief interventions that include explicit advice about safe drinking limits. [12][13][14] In addition, offering feedback about specific risks or consequences of their drinking to patients who drink heavily can help motivate them to decrease alcohol consumption or seek treatment. 15,16 Physicians report they would be more likely to advise patients about safe drinking practices if they were more confident of their knowledge about safe levels of alcohol consumption. 17 Women who drink more than two drinks daily on average, or who frequently drink five or more d...

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The association of alcohol consumption with outcome of pregnancy.

Abstract: Patterns of alcohol consumption were assessed in 12,440 pregnant women interviewed at the time of delivery. Only 92 women (0

Cited by 139 publications

References 13 publications

Maternal alcohol consumption during pregnancy and physical outcomes up to 5 years of age: a longitudinal study

Maternal alcohol consumption during pregnancy and physical outcomes up to 5 years of age: a longitudinal study

Anal atresia: Effect of smoking and drinking habits during pregnancy

Medical risks for women who drink alcohol

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