The association of c.1471G&gt;A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population

Wang, Li; Chen, Zhenhong; Wang, Yajuan; Chang, Dan; Su, Longxiang; Guo, Yinghua; Liu, Changting

doi:10.1007/s13277-014-1702-x

Tumor Biol.

2014

DOI: 10.1007/s13277-014-1702-x

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The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population

Li Wang

Zhenhong Chen

Yajuan Wang

et al.

Abstract: OR=2.69, 95 % CI=1.55-4.69, P<0.001; A vs. G: OR=1.37, 95 % CI=1.09-1.71, P=0.007]. The allele A and genotype AA may contribute to the susceptibility to lung cancer. Taken together, these results showed that the functional c.1471G>A genetic polymorphism of XRCC1 was associated with lung cancer susceptibility in the studied population.

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Cited by 6 publications

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“…The X-ray repair cross-complementing group 1 (XRCC1) gene plays an important role in the development of lung cancer (Wang et al, 2014). XRCC1 protein plays a central role in base excision repair (BER) pathway by interacting with other DNA repair proteins (Yin et al, 2009).…”

mentioning

confidence: 99%

Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

Saikia¹,

Phukan²,

Sharma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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mentioning

confidence: 99%

Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

Saikia¹,

Phukan²,

Sharma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The relationship between genetic variants of XRCC1 gene and lung cancer susceptibility in Chinese Han population

Tang

Zhao

2014

Med Oncol

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Previous evidence indicate that genetic variants of X-ray repair cross-complementing group 1 gene (XRCC1) are potentially associated with the development of lung cancer. This study aimed to detect the relationship between the XRCC1 genetic variants and lung cancer susceptibility. A total of 420 lung cancer patients and 425 cancer-free healthy controls were recruited in this case-control study. The genotypes of XRCC1 genetic variants were investigated by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The relationship between the XRCC1 genetic variants and lung cancer susceptibility was determined by the association analyses. We found that the distributions of allelic and genotypic in lung cancer patients were significantly different from those of cancer-free healthy controls. Our data indicated that the XRCC1 c.1161G>A and c.1779C>G genetic variants were significantly associated with the increased susceptibility to lung cancer [for c.1161G>A, AA versus (vs.) GG: odds ratio (OR) 2.59, 95 % confidence interval (95 % CI) 1.59-4.21, χ (2) = 15.17, P < 0.001; A vs. G: OR 1.39, 95 % CI 1.13-1.70, P = 0.002; for c.1779C>G, GG vs. CC: OR 2.51, 95 % CI 1.42-4.44, χ (2) = 10.60, P = 0.001; G vs. C: OR 1.24, 95 % CI 1.00-1.54, χ (2) = 3.98, P = 0.046]. The allele A and genotype AA of c.1161G>A and allele G and genotype GG of c.1779C>G genetic variants may enhance lung cancer susceptibility. Taken together, these findings show that the functional c.1161G>A and c.1779C>G genetic variants of XRCC1 are associated with lung cancer susceptibility in the Chinese Han populations and might be used as molecular markers for evaluating the risk of lung cancer.

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The programmed cell death 6 interacting protein insertion/deletion polymorphism is associated with non-small cell lung cancer risk in a Chinese Han population

Liu

Yuan

et al. 2014

Tumor Biol.

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It has been proposed that genetic factors contribute to the susceptibility of non-small cell lung cancer (NSCLC). The programmed cell death 6 interacting protein (PDCD6IP) encodes for a protein that has been known to bind to the products of the PDCD6 gene, a required protein in apoptosis. The aim of this study is to investigate the relationship between PDCD6IP insertion/deletion (I/D) polymorphism (rs28381975) and NSCLC risk in a Chinese population. A population-based case-control study was conducted in 449 NSCLC patients and 512 cancer-free controls. The genotype of the PDCD6IP gene was determined by using a polymerase chain reaction assay. The promoter activity was analyzed by luciferase reporter assay in A549 and H1299 cells. Statistically significant difference was observed when the patients and controls were compared according to ID + II versus DD (OR = 1.72, 95 % CI 1.29-2.31, P < 0.01). The I allele was significantly associated with NSCLC risk (OR = 1.41, 95 % CI 1.18-1.69, P < 0.01). Compared to TNM stage I + II, PDCD6IP I/D polymorphism significantly increased advanced NSCLC risk (OR = 2.06, 95 % CI 1.30-3.26, P < 0.01). Promoter reporter structures carrying the I allele displayed significantly higher promoter activity than the D allele in A549 and H1299 cells (P = 0.001). The results from this study suggested that PDCD6IP I/D polymorphism was potentially related to NSCLC susceptibility in Chinese Han population.

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The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population

Cited by 6 publications

References 40 publications

Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

The relationship between genetic variants of XRCC1 gene and lung cancer susceptibility in Chinese Han population

The programmed cell death 6 interacting protein insertion/deletion polymorphism is associated with non-small cell lung cancer risk in a Chinese Han population

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