The Association of Calcium and Vitamin D Use With Implant Survival of Total Knee Arthroplasty: A Nationwide Population-Based Cohort Study

Kong, Youngho; Han, Minkyung; Lee, Minyoung; Kim, Eun Hwa; Jung, Inkyung; Park, Kwan Kyu

doi:10.1016/j.arth.2020.08.003

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…The association between calcium and vitamin D utilization and arthroplasty survival is poorly understood. Kong et al 7 performed a nationwide population-based cohort study of patients who underwent a total knee arthroplasty between 2009 and 2018, utilizing the Korean National Health Insurance Database. Of 142,000 patients, 28,403 took calcium and vitamin D and were compared with 113,744 patients who had never taken calcium and vitamin D. Implant survival was significantly improved in the patients who took calcium and vitamin D for >11 years compared with the patients who did not (log-rank p < 0.001).…”

Section: Calcium and Vitamin Dmentioning

confidence: 99%

What’s New in Osteoporosis and Fragility Fractures

Hansen

Tutaworn

Lane

2022

Journal of Bone and Joint Surgery

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In this article, we establish a baseline status of clinical and basic research in the area of osteoporosis and fragility fractures, focused primarily on research published within the past 12 to 24 months. This topic will be an addition to the JBJS annual list of Guest Editorial topics.Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJS/H163).

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Section: Calcium and Vitamin Dmentioning

confidence: 99%

What’s New in Osteoporosis and Fragility Fractures

Hansen

Tutaworn

Lane

2022

Journal of Bone and Joint Surgery

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“…Kong et al (2021) [ 20 ] investigated the relationship between calcium and vitamin D use and the revision rate after primary total knee replacement surgery. The authors performed a population cohort study using the Korean National Health Insurance database that included all patients who underwent primary total knee replacement between 2009 and 2018.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 142,147 patients were included in the analysis and only about 20% of the respondents (n = 28,403) took preparations containing vitamin D and calcium. It has been proven that implant survival was significantly better in people taking a combination of calcium and vitamin D (at a dose of 800 IU or more) for more than 1 year compared to those who had never used it ( p < 0.001) [ 20 ]. Song et al (2021) [ 21 ] undertook to investigate the effect of vitamin D levels on early clinical function outcomes and potential risk factors for moderate to severe pain in postmenopausal women after TKA.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

Płomiński

Grzybowski

Fiedorowicz

et al. 2022

IJMS

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Vitamin D takes part in the functioning of many processes that ensure the homeostasis of the body. In orthopedics, it is indicated as an inseparable element ensuring proper bone growth and functioning, and its deficiencies are indicated in various diseases, mainly in the proper structure and function of the skeleton. In this review, we focus on the most important components of the vitamin D metabolic pathway, in correlation with selected orthopedic conditions. Records were obtained from the PubMed database in a timeline of 2010–2022. The keywords were as follows: vitamin D/cholesterol/vitamin D binding protein/ VDBP/Cytochrome/CYP24A1/CYP 27B1/Vitamin D receptor/VDR/ + diseases (ACL reconstruction, rotator cuff, arthroplasty knee/hip/shoulder). The recent original studies were analyzed, discussed, and the most important data were shown. The vast majority of articles concern the metabolite of vitamin D (25(OH)D), which is measured as a standard in diagnostic laboratories. Even though there is a lot of valuable information in the literature, we believe that the other elements of the vitamin D pathway also deserve attention and suggest their research in correlation with orthopedic disorders to supplement the missing knowledge on this topic.

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“…Osteoporosis has become one of the common comorbidities in patients undergoing primary noncemented THA. Previous studies have reported on the effect of bone health on implant-related complications after primary noncemented THA and implant survivorship, 11 illustrating that osteoporosis is a notable risk factor for the development of periprosthetic fracture after primary THA and revision THA. In a radiostereometric analysis, Aro et al 12 reported that osteoporosis can lead to four possible complications of noncemented THA: increased migration (subsidence) of the stem, delay in osteointegration, increased risk of periprosthetic fracture, and risk of late loosening due to the mechanical failure of ingrown trabecular bone.…”

Section: Discussionmentioning

confidence: 99%

Artificial Neural Networks Can Predict Early Failure of Cementless Total Hip Arthroplasty in Patients With Osteoporosis

Cohen-Levy¹,

Melnic²,

Kwon³

2022

J Am Acad Orthop Surg

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Background: Total hip arthroplasty (THA) done in the aging population is associated with osteoporosis-related complications. The altered bone density in osteoporotic patients is a risk factor for revision surgery. This study aimed to develop and validate machine learning (ML) models to predict revision surgery in patients with osteoporosis after primary noncemented THA. Methods: We retrospectively reviewed a consecutive series of 350 patients with osteoporosis (T-score less than or equal to 22.5) who underwent primary noncemented THA at a tertiary referral center. All patients had a minimum 2-year follow-up (range: 2.1 to 5.6). Four ML algorithms were developed to predict the probability of revision surgery, and these were assessed by discrimination, calibration, and decision curve analysis. Results: The overall incidence of revision surgery was 5.2% at a mean follow-up of 3.7 years after primary noncemented THA in osteoporotic patients. Revision THA was done because of periprosthetic fracture in nine patients (50%), aseptic loosening/subsidence in five patients (28%), periprosthetic joint infection in two patients (11%) and dislocation in two patients (11%). The strongest predictors for revision surgery in patients after primary noncemented THA were female sex, BMI (.35 kg/m 2 ), age (.70 years), American Society of Anesthesiology score ($3), and T-score. All four ML models demonstrated good model performance across discrimination (AUC range: 0.78 to 0.81), calibration, and decision curve analysis. Conclusion:The ML models presented in this study demonstrated high accuracy for the prediction of revision surgery in osteoporotic patients after primary noncemented THA. The presented ML models have the potential to be used by orthopaedic surgeons for preoperative patient counseling and optimization to improve the outcomes of primary noncemented THA in osteoporotic patients.

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The Association of Calcium and Vitamin D Use With Implant Survival of Total Knee Arthroplasty: A Nationwide Population-Based Cohort Study

Cited by 10 publications

References 36 publications

What’s New in Osteoporosis and Fragility Fractures

What’s New in Osteoporosis and Fragility Fractures

Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

Artificial Neural Networks Can Predict Early Failure of Cementless Total Hip Arthroplasty in Patients With Osteoporosis

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