The association of cardiorespiratory fitness, body mass index, and age with testosterone levels at screening of healthy men undergoing preventive medical examinations: The Cooper Center Longitudinal Study

DeFina, Laura F.; Radford, Nina B.; Léonard, David; Wilson, Rick K.; Cooper, Tyler; Clark, S. Michael; Willis, Benjamin L.; Vega, Gloria Lena; Barlow, Carolyn E.; Farrell, Stephen W.; Gibbons, Larry W.; Yildiz, Bülent O.; Gruntmanis, Uģis

doi:10.1016/j.maturitas.2018.09.004

Cited by 13 publications

(12 citation statements)

References 28 publications

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“…We speculate that a decline in testosterone levels with age could affect physiological variables (DeFina et al 2018;Hosick et al 2018;Kelsey et al 2014), which may influence results when using the EB equation for men. Another explanation might be that both pre-pubertal boys and elderly men with low absolute VO 2 max are outside or at the lower end of the VO 2 max range in the EB sample for men in Bjorkman et al (2016), indicating a more uncertain estimation Fig.…”

Section: Discussionmentioning

confidence: 99%

Criterion validity of the Ekblom-Bak and the Åstrand submaximal test in an elderly population

et al. 2019

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The aim of this study was to validate the submaximal Ekblom-Bak test (EB-test) and the Åstrand test (Å-test) for an elderly population. Methods Participants (n = 104), aged 65-75 years, completed a submaximal aerobic test on a cycle ergometer followed by an individually adjusted indirect calorimetry VO 2 max test on a treadmill. The HR from the submaximal test was used to estimate VO 2 max using both the EB-test and Å-test equations. Results The correlation between measured and estimated VO 2 max using the EB method and Å method in women was r = 0.64 and r = 0.58, respectively and in men r = 0.44 and r = 0.44, respectively. In women, the mean difference between estimated and measured VO 2 max was − 0.02 L min −1 (95% CI − 0.08 to 0.04) for the EB method and − 0.12 L min −1 (95% CI − 0.22 to − 0.02) for the Å method. Corresponding values for men were 0.05 L min −1 (95% CI − 0.04 to 0.14) and − 0.28 L min −1 (95% CI − 0.42 to − 0.14), respectively. However, the EB method was found to overestimate VO 2 max in men with low fitness and the Å method was found to underestimate VO 2 max in both women and men. For women, the coefficient of variance was 11.1%, when using the EB method and 19.8% when using the Å method. Corresponding values for men were 11.6% and 18.9%, respectively. Conclusion The submaximal EB-test is valid for estimating VO 2 max in elderly women, but not in all elderly men. The Å-test is not valid for estimating VO 2 max in the elderly.

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Section: Discussionmentioning

confidence: 99%

Criterion validity of the Ekblom-Bak and the Åstrand submaximal test in an elderly population

et al. 2019

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“…The decline in testosterone plasmatic levels may be intensified with low physical capacities in aging individuals. The Cooper Center longitudinal study has shown that low testosterone levels were directly associated with decreased CRF in elderly men ( DeFina et al, 2018 ). In a cohort study (≥65 years; n = 2,587), an inverse association was shown between testosterone levels and physical function and risk of falls in 4 years of follow-up.…”

Section: Anabolic-androgenic Steroids When Exercise Seems Ineffective...mentioning

confidence: 99%

Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia

2022

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Sarcopenia is an emerging clinical condition determined by the reduction in physical function and muscle mass, being a health concern since it impairs quality of life and survival. Exercise training is a well-known approach to improve physical capacities and body composition, hence managing sarcopenia progression and worsening. However, it may be an ineffective treatment for many elderly with exercise-intolerant conditions. Thus, the use of anabolic-androgenic steroids (AAS) may be a plausible strategy, since these drugs can increase physical function and muscle mass. The decision to initiate AAS treatment should be guided by an evidence-based patient-centric perspective, once the balance between risks and benefits may change depending on the clinical condition coexisting with sarcopenia. This mini-review points out a critical appraisal of evidence and limitation of exercise training and AAS to treat sarcopenia.

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“…Moreover, we performed a subgroup analysis by BMI (normal weight, overweight, and obese) to investigate whether specific BMI subgroups of seniors are more sensitive with regard to the relationship between testosterone and WOMAC scores or K/L grades. These analyses were performed because obesity is a very well documented risk factor for knee OA (35,36), and several studies have shown that testosterone levels are inversely associated with BMI (37,38). Statistical significance was set at a P value less than or equal to 0.05; reported P values are 2-sided.…”

Section: Significance and Innovationsmentioning

confidence: 99%

Total Serum Testosterone and Western Ontario and McMaster Universities Osteoarthritis Index Pain and Function Among Older Men and Women With Severe Knee Osteoarthritis

Freystätter

Fischer

Orav

et al. 2020

Arthritis Care & Research

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Objective. To investigate whether serum total testosterone level is associated with knee pain and function in men and women with severe knee osteoarthritis (OA). Methods. We enrolled 272 adults age ≥60 years (mean ± SD age 70.4 ± 4.4 years, 53% women) who underwent unilateral total knee replacement (TKR) due to severe knee OA. Serum testosterone levels and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function of the operated and contralateral knee were measured at 6-8 weeks after surgery. At the nonoperated knee, 56% of participants had radiographic knee OA with a Kellgren/Lawrence grade ≥2. Cross-sectional analyses were performed by sex and body mass index (BMI) subgroups, using multivariable regression adjusted for age, physical activity, and BMI. Results. At the operated knee, higher testosterone levels were associated with less WOMAC pain in men (B =-0.62, P = 0.046) and women (B =-3.79, P = 0.02), and less WOMAC disability scores in women (B =-3.62, P = 0.02) and obese men (B =-1.99, P = 0.02). At the nonoperated knee, testosterone levels were not associated with WOMAC pain in men or women, but higher testosterone levels were associated with less disability in women (B =-0.95, P = 0.02). Testosterone levels were inconsistently associated with pain and disability in BMI subgroups among men. Only among obese women, testosterone levels were inversely associated with radiographic knee OA (odds ratio = 0.10, P = 0.003). Conclusion. Higher total testosterone levels were associated with less pain in the operated knee in men and women undergoing TKR and less disability in women. At the nonoperated knee, higher testosterone levels were inconsistently associated with less pain and disability.

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The association of cardiorespiratory fitness, body mass index, and age with testosterone levels at screening of healthy men undergoing preventive medical examinations: The Cooper Center Longitudinal Study

Cited by 13 publications

References 28 publications

Criterion validity of the Ekblom-Bak and the Åstrand submaximal test in an elderly population

Criterion validity of the Ekblom-Bak and the Åstrand submaximal test in an elderly population

Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia

Total Serum Testosterone and Western Ontario and McMaster Universities Osteoarthritis Index Pain and Function Among Older Men and Women With Severe Knee Osteoarthritis

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