The association of carotid intima-media thickness with body mass index and cortisol level in fibromyalgia syndrome

Koca, Tuba Tülay; Çimen, Ayla Özaydoğdu

doi:10.18621/eurj.376343

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…All these markers had effect size estimators around zero, and the distribution of estimators across studies showed a highly conflicting picture for almost all main outcome measures. For example, approximately half of the studies reported decreased levels of blood cortisol 19,21,22,38,69,89 or ACTH 1,13,81,89 for individuals with FMS compared with FMS-free controls, whereas the other half reported increased levels for the respective outcome measures. 3,6,7,12,14,60 This suggests that these markers do not appear to be altered per se in FMS.…”

Section: Discussionmentioning

confidence: 99%

Stress biomarkers in individuals with fibromyalgia syndrome: a systematic review with meta-analysis

Beiner¹,

Lucas²,

Reichert³

et al. 2023

Pain

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Section: Discussionmentioning

confidence: 99%

Stress biomarkers in individuals with fibromyalgia syndrome: a systematic review with meta-analysis

Beiner¹,

Lucas²,

Reichert³

et al. 2023

Pain

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“…No statistically significant difference was found between the two groups. However, the effect of acute phase reactants was not evaluated in this study, and in our research, the result of acute phase reactants on CIMT was also assessed 40 …”

Section: Discussionmentioning

confidence: 92%

Subclinical atherosclerosis in fibromyalgia syndrome

Gul,

Yildiz,

Atik

et al. 2023

Sonography

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IntroductionFibromyalgia syndrome (FMS) is a chronic disease of unknown pathophysiology in which inflammatory markers are not increased. The risk of cardiovascular disease is known to be raised in FMS. Determination of carotid intima‐media thickness (CIMT) is essential for the early detection of cardiovascular disease risk. In this study, we aimed to investigate how FMS affects CIMT and its relationship with disease duration.MethodsThis study was planned prospectively and included 20 female FMS patients and 20 healthy female controls. Detailed medical histories were obtained. Persons with a known chronic disease (diabetes mellitus, hypertension, thyroid function disorder, rheumatic disease, etc.), known atherosclerotic condition, body mass index >30 and smokers were excluded. Laboratory values of FMS patients and the control group in the last 3 months were recorded. The patients' and control groups' right and left common carotid arteries were imaged with ultrasonography.ResultsThere was no significant difference in laboratory values (although creatinine was different, it was within the normal range in both groups). The mean right common carotid artery intima‐media thickness was 0.5 (±0.07) mm in the patient group and 0.43 (±0.05) mm in the control group (p = .005). The mean left common carotid artery intima‐media thickness was 0.5 (±0.06) mm in the patient group and 0.43 (±0.05) mm in the control group (p = .001). Carotid intima‐media thickness values were significantly higher in the patient group than in the control group.ConclusionsAlthough FMS is not an inflammatory disease, it causes endothelial dysfunction and atherosclerosis.

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“…This suggests that hsCRP may only have a moderating function and may be less causally involved in the pathogenesis of FMS than an expression of possible co-morbidities associated with both FMS and inflammatory processes. A central co-factor that is repeatedly discussed here is obesity, which is associated with both FMS and subclinical inflammatory processes (10,35).…”

Section: Association Between Hscrp Concentrations and Clinical Measuresmentioning

confidence: 98%

Elevated high sensitive C-reactive protein in fibromyalgia

Beiner,

Brenner Miguel,

Friederich

et al. 2023

Front. Psychiatry

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IntroductionFibromyalgia syndrome (FMS) is a complex chronic pain condition characterized by widespread pain and tenderness, fatigue, and sleep disturbances. Currently, factors contributing to FMS are considered to be multifactorial, and the involvement of inflammatory processes is a question of debate.ObjectiveThe aims of this study were (1) to assess whether serum concentrations of high-sensitivity C-reactive protein (hsCRP) differ between individuals diagnosed with FMS and pain-free controls, (2) to determine whether these differences are associated with clinical symptoms, and (3) to explore whether the observed differences can be explained by specific covariates such as age, weight, and smoking status.MethodsAn ANOVA was applied to identify differences of hsCRP levels between FMS and pain-free controls and an analysis of covariance (ANCOVA) was performed to investigate the dependencies of hsCRP with respect to covariates. To assess the reliability of our findings, we also utilized a Bayesian robust estimation model to determine the level of confidence associated with our results.ResultsThe results showed that individuals with FMS had higher hsCRP levels compared to healthy controls [F(1,106) = 8.802, p < 0.001] and that higher hsCRP levels were significant correlated with a higher symptom burden (r = 0. 287, p = 0.008) and more tender points (r = 0.307, p = 0.005). Further, hsCRP levels were significantly associated with weight (η2 = 0.154, p < 0.001), but independent of age (η2 = 0.005, p = 0.42), smoking status (η2 = 0.002, p = 0.623), or gender (η2 = 0.0045, p = 0.437), which resulted in an insignificant group effect between FMS and controls (η2 = 0.029, p = 0.052), even after controlling for covariates.ConclusionIn conclusion, this study provides evidence that sub-inflammatory processes correlate with clinical symptoms, which can be partly attributed to differences in weight, but cannot be fully explained by them. Further research is needed to elucidate the mechanisms underlying the association between hsCRP and FMS and to explore the potential therapeutic implications of targeting hsCRP in the management of FMS.

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The association of carotid intima-media thickness with body mass index and cortisol level in fibromyalgia syndrome

Cited by 5 publications

References 17 publications

Stress biomarkers in individuals with fibromyalgia syndrome: a systematic review with meta-analysis

Stress biomarkers in individuals with fibromyalgia syndrome: a systematic review with meta-analysis

Subclinical atherosclerosis in fibromyalgia syndrome

Elevated high sensitive C-reactive protein in fibromyalgia

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