The association of childhood iron deficiency anaemia with severe dental caries

Shaoul, Ron; Gaitini, Louis; Kharouba, Johni; Darawshi, Geith; Maor, Irit; Somri, Mostafa

doi:10.1111/j.1651-2227.2011.02448.x

Cited by 38 publications

(54 citation statements)

References 12 publications

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“…In fact, the adjusted odds of children with S-ECC having low ferritin was nearly double that of cavity-free children. More recently, another group has reported a similar significant relationship between rampant caries during childhood and low ferritin status [19]. They reported that children with rampant caries had significantly lower levels of ferritin, haemoglobin, and iron than a group of caries-free controls [19].…”

Section: Discussionmentioning

confidence: 97%

Association between iron status, iron deficiency anaemia, and severe early childhood caries: a case–control study

et al. 2013

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BackgroundSevere tooth decay is known to affect the health and well-being of young children. However, little is known about the influence of Severe Early Childhood Caries (S-ECC) on childhood nutritional status. The purpose of this study was to contrast ferritin and haemoglobin levels between preschoolers with S-ECC and caries-free controls.MethodsChildren were recruited as part of a larger case–control study examining differences in nutritional status between those with and without S-ECC. Preschoolers with S-ECC were recruited on the day of their dental surgery, while caries-free controls were recruited from the community. Parents completed a questionnaire and the child underwent venipuncture. The study was approved by the University’s Health Research Ethics Board. Statistics included descriptive, bivariate and logistic regression analyses. A p value ≤ .05 was significant. A total of 266 children were recruited; 144 with S-ECC and 122 caries-free.ResultsThe mean age was 40.8 ± 14.1 months. The mean ferritin concentration for all children was 29.6 ± 17.9 μg/L while the mean haemoglobin level was 115.1 ± 10.1 g/L. Children with S-ECC were significantly more likely to have low ferritin (p=.033) and low haemoglobin levels (p>.001). Logistic regression analyses revealed that children with S-ECC were nearly twice as likely to have low ferritin levels and were over six times more likely to have iron deficiency anaemia than caries-free controls.ConclusionsChildren with S-ECC appear to be at significantly greater odds of having low ferritin status compared with caries-free children and also appear to have significantly lower haemoglobin levels than the caries-free control group. Children with S-ECC also appear to be at significantly greater odds for iron deficiency anaemia than cavity-free children.

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Section: Discussionmentioning

confidence: 97%

Association between iron status, iron deficiency anaemia, and severe early childhood caries: a case–control study

et al. 2013

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“…22 Shaoul et al have observed severe dental caries in children with iron deficiency. 23 As for the interpretation of the data on eating habits, the present study may have some limitations due to information and interpretation biases, with regard to the information the children's parents were asked about, as well as the bias in recall of this information.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of black stain and associated risk factors in preschool Spanish children

Martín

García

Lestón

et al. 2013

Pediatrics International

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“…The effects may be related to the ability of iron ions to incorporate into the apatitic crystal by reacting with phosphate and creating a barrier of ferric phosphate that could prevent demineralization [46, 50, 51]. However, detailed studies using human tooth enamel combined with X-ray diffraction and microhardness/micro-Computed Tomography testing are needed to elucidate how CAT-NP affect enamel structure and/or disrupt apatite acid-dissolution.…”

Section: Discussionmentioning

confidence: 99%

Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo

et al. 2016

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Dental biofilms (known as plaque) are notoriously difficult to remove or treat because the bacteria can be enmeshed in a protective extracellular matrix. It can also create highly acidic microenvironments that cause acid-dissolution of enamel-apatite on teeth, leading to the onset of dental caries. Current antimicrobial agents are incapable of disrupting the matrix and thereby fail to efficiently kill the microbes within plaque-biofilms. Here, we report a novel strategy to control plaque-biofilms using catalytic nanoparticles (CAT-NP) with peroxidase-like activity that trigger extracellular matrix degradation and cause bacterial death within acidic niches of caries-causing biofilm. CAT-NP containing biocompatible Fe3O4 were developed to catalyze H2O2 to generate free-radicals in situ that simultaneously degrade the biofilm matrix and rapidly kill the embedded bacteria with exceptional efficacy (>5-log reduction of cell-viability). Moreover, it displays an additional property of reducing apatite demineralization in acidic conditions. Using 1-minute topical daily treatments akin to a clinical situation, we demonstrate that CAT-NP in combination with H2O2 effectively suppress the onset and severity of dental caries while sparing normal tissues in vivo. Our results reveal the potential to exploit nanocatalysts with enzyme-like activity as a potent alternative approach for treatment of a prevalent biofilm-associated oral disease.

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The association of childhood iron deficiency anaemia with severe dental caries

Cited by 38 publications

References 12 publications

Association between iron status, iron deficiency anaemia, and severe early childhood caries: a case–control study

Association between iron status, iron deficiency anaemia, and severe early childhood caries: a case–control study

Prevalence of black stain and associated risk factors in preschool Spanish children

Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo

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