The Association of Daily Activity Levels and Estimated Kidney Function in Men and Women With Predialysis Chronic Kidney Disease

Abstract

IntroductionChronic kidney disease (CKD) is often accompanied by complications including poor physical activity level. However, only a few studies have objectively characterized physical activity levels in predialysis CKD. Our study sought to measure daily activity levels by accelerometry in individuals with CKD (stages III−V) and to determine the association between daily activity and kidney function.MethodsWe determined kidney function by means of the estimated glomerular filtration rate (eGFR) using the Modification of Diet and Renal Disease (MDRD) equation. Participants wore an accelerometer for 7 consecutive days, and we measured multiple physical activity outcomes including total daily activity, sedentary, light, and moderate−vigorous activity. Average durations and intensity of activity were determined according to stage of CKD. The association between kidney function and activity level was determined by regression analysis.ResultsWe analyzed data from 110 individuals (60% men and 40% women) with stages III to V CKD. The mean age of our participants was 64 years, mean body mass index was 27.5 kg/m2, and mean eGFR was 23.7 ± 1.2 ml/min/1.73 m2. Our participants were primarily sedentary (mean duration of inactivity = 1152 ± 100 minutes per day; 79% of day). Light activity was performed 280 ± 99 minutes per day, and individuals participated in only 6 ± 9 minutes per day of moderate−vigorous activity. The eGFR did not predict physical activity level (P > 0.05 for all).DiscussionIndividuals with stages III to V CKD are sedentary, and do not meet the national recommendations of 150 minutes of moderate−vigorous activity per week. Further study is required to determine whether interventions to increase activity levels in patients with CKD are associated with improved health outcomes.

Altered vascular function in chronic kidney disease: evidence from passive leg movement

“…It was recently reported that a standard group of stage 3–5 nondialysis CKD patients acquired only 6 ± 9 min of moderate‐to‐vigorous intensity physical activity per day, suggesting that these patients achieve far less than the national recommendations of 150 min per week (West et al. ). Similarly, significantly reduced VO 2 peak measurements have been reported in patients with CKD when compared to sedentary age‐predicted norms (Padilla et al.…”

Risk of Kidney Dysfunction from Polypharmacy among Older Patients: A Nested Case-Control Study of the South Korean Senior Cohort

“…The medication-specific risk factors were angiotensin-converting-enzyme inhibitors (ACEIs) 63–66 , angiotensin II receptor blockers (ARBs) 63–67 , metformin 68 , statins 69 , non-steroidal anti-inflammatory drugs (NSAIDs) 50,63–66,70,71 , proton pump inhibitors (PPIs) 64,65,72–74 , and allopurinol 63,65,75 . Finally, the lifestyle-related risk factors were smoking 38,39,41–43,50,59,76–79 , alcohol consumption 41,43,76,80,81 , and physical activity 43,59,82–85 .…”

The Relationship between Physical Activity Levels and Functional Capacity in Patients with Advanced Chronic Kidney Disease

“…However, based on the 12-Item Short Form Health Survey (SF-12) questionnaire, Barthel Index, and Timed Up-And-Go Test, they found no differences in the HRQoL of these patients. In addition, a Canadian study showed that there was no relationship between physical activity levels (measured using pedometers) and renal function (assessed by glomerular filtration rates), although the authors did note that patients with CKD-5D had a sedentary lifestyle (West et al, 2017). A similar study in Spain concluded that there were no differences in physical activity levels or HRQoL in patients with CKD-5D, although this cohort excluded patients aged over 70 years and only included six patients on HD and eight patients on PD (Hernández Sánchez et al, 2015).…”