The association of diabetes mellitus with carotid atherosclerosis and arterial stiffness in the Corinthia study

Theofilis, Panagiotis; Oikonomou, Evangelos; Lazaros, George; Vogiatzi, Georgia; Anastasiou, Μaria; Mystakidi, Vasiliki Chara; Goliopoulou, Athina; Christoforatou, Evangelia; Bourouki, Evgenia; Vavouranaki, Georgia; Μαρίνος, Γεώργιος; Tousoulis, Dimitris

doi:10.1016/j.numecd.2021.12.013

Cited by 9 publications

(7 citation statements)

References 68 publications

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“…However, the data of drug history is not available and validation analysis cannot be perfomed, which is the de ciency of this study. However, previous studies have found association of carotid plaque formation with diabetes and hypertension [29,31]. Our study suggest that MHR level is also correlated with carotid plaque formation and development in people without diabetes and hypertension.…”

Section: Discussionsupporting

confidence: 45%

“…This study found that the proportion of subjects with diabetes and hypertension did rise with the severity of plaque. This may caused by disorders of glucose and lipid metabolism in most diabetes or hypertension patients, and the incidence of carotid plaques is increased [29][30][31][32][33]. Thus in further analysis, we compared subjects with diabetes, hypertension and those without these two diseases respectively.…”

Section: Discussionmentioning

confidence: 99%

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Blood monocyte to high density lipoprotein cholesterol ratio (MHR) can be used as an independent risk factor of carotid artery plaque

Men

Nan

et al. 2022

Preprint

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Background: Carotid plaque is a manifestation of carotid atherosclerosis,monocytes play a key role in atherosclerosis related inflammatory response ,high density lipoprotein cholesterol (HDL-C) has vascular protective effects such as anti-inflammatory, antithrombotic and anti atherosclerosis. This study is to investigate the relationships of MHR level and the incidence of carotid artery plaque. Methods: Data of physical examination personnel in the first medical center of the General Hospital of PLA from January to April in 2018 was collected and 3848 subjects were included for retrospectively analysis. Statistical analysis was performed on Spss 22.0 0 software and statistical software R and its GAM package.Results: The difference was statistically significant in levels of MHR, body mass index (BMI), high-sensitive C-reactive protein (hs-CRP), blood lipids (HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol(TC), triglyceride(Tg)), blood glucose(Glu), Hyperglycemic hemoglobin(HbA1c), renal function (Urea, creatinine(Crea), estimated glomerular filtration rate(eGFR), Uric acid (Ua)) in carotid plaque groups (p=0.000,respectively). No significant difference between the gender (p=0.635) and age(p=0.063) in different groups. MHR levels was positively correlated with levels of BMI (r = 0.364, P = 0.000), hs-CRP (r = 0.320, P =0.000), Tg (r = 0.417, P=0.000), Crea(r=0.323, P=0.000), eGFR(r=-0.248, P=0.000), Ua(r=0.383, P=0.000) and HbA1c (r=0.197, P=0.000). Levels of TC, Glu, Urea were slightly correlated with MHR level(r=-0.150, P=0.000; r=0.187, P=0.000; r=0.137, P=0.000; respectively ). In subjects with both hypertension and diabetes, MHR levels showed difference among three groups (p=0.009). MHR level increased with elevated site number of carotid plaque in subjects without hypertension or diabetes(p=0.000). MHR level still showed differences among carotid plaque groups in subjects with hypertension and diabetes. In adjusted models, the probability of occurrence of carotid plaque increased by1.958 (95% CI: 1.144-3.351, P = 0.000) times; The probability of multiple occurrence of carotid plaques increased by 2.068 (95% CI: 1.100-3.887, P = 0.000) times. The GAM curve showed a non-linear correlation between normalized MHR and the probability of carotid plaque occurrence. Conclusions: MHR could be used as an independent risk factor and indicator for plaque formation and severity.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Blood monocyte to high density lipoprotein cholesterol ratio (MHR) can be used as an independent risk factor of carotid artery plaque

Men

Nan

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…This study found that the proportion of subjects with diabetes and hypertension increased with the severity of plaque. This may be caused by disorders of glucose and lipid metabolism in most diabetes or hypertension patients, and the incidence of carotid plaques is increased [ 24 – 28 ]. Thus, in further analysis, we compared subjects with diabetes, hypertension and those without these two diseases.…”

Section: Discussionmentioning

confidence: 99%

The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

Men

Nan

et al. 2022

Lipids Health Dis

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Background MHR is the ratio of monocyte to high-density lipoprotein cholesterol (HDL-C). It has been reported that MHR changes are associated with cardiovascular and cerebrovascular disease. Carotid plaque is a common vascular lesion of the carotid artery and is a manifestation of atherogenesis. This study investigated the relationships between the MHR and the incidence of carotid plaques. Methods The data of 3848 physical examiners were analyzed for retrospective analysis, which included 1428 patients with noncarotid plaque, 1133 patients with single carotid plaque, and 1287 patients with bilateral or multiple carotid plaques. Statistical analysis was performed on SPSS 22.0 0 software and statistical software R and its GAM package. Results The difference was statistically significant in the levels of MHR, body mass index (BMI), high-sensitivity C-reactive protein (hs-CRP), blood lipids (HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (Tg)), blood glucose (Glu), hemoglobin A1c (HbA1c), renal function (urea, creatinine (Crea)), estimated glomerular filtration rate (eGFR), and uric acid (Ua) in the carotid plaque groups (P < 0.001, respectively). There was no significant difference between the sex (P = 0.635) and age (P = 0.063) in the different groups. MHR levels were positively correlated with BMI (r = 0.364, P < 0.001), hs-CRP (r = 0.320, P < 0.001), Tg (r = 0.417, P < 0.001), Crea (r = 0.323, P < 0.001), eGFR (r = − 0.248, P < 0.001), Ua (r = 0.383, P < 0.001) and HbA1c (r = 0.197, P < 0.001). Levels of TC, Glu, and urea were slightly correlated with the MHR level (r = − 0.150, P < 0.001; r = 0.187, P < 0.001; r = 0.137, P < 0.001, respectively). The MHR level increased with elevated severity of carotid plaque in subjects without hypertension or diabetes (P < 0.001). In adjusted models, with the rise of MHR level, the probability of occurrence of carotid plaque had a 1.871-fold (95% CI: 1.015–3.450, P = 0.045) increase; the probability of multiple occurrences of carotid plaques had a 2.896-fold (95% CI: 1.415–5.928, P < 0.001) increase. The GAM curve showed a nonlinear correlation between the normalized MHR and the probability of carotid plaque occurrence. Conclusions MHR could be used as a possible marker for plaque formation and severity.

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“…2,19 Data regarding the interaction between diabetes and central systolic BP is sparse, however, diabetes seems to be associated with increased arterial stiffness. 10,[12][13][14][15][16] In type 2 diabetes, increased arterial stiffness is associated with cardiovascular risk, independently of glycemic control and ambulatory BP. 13 We found that diabetes was associated with an increase in the delta systolic pressure, independently of b-blocker exposure.…”

Section: Discussionmentioning

confidence: 99%

The impact of β‐blockers on the central and delta systolic pressures in a real‐world population with treated hypertension: A cross‐sectional study

Bénard

Durand

Berthoumieux³

et al. 2022

Health Science Reports

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The association of diabetes mellitus with carotid atherosclerosis and arterial stiffness in the Corinthia study

Cited by 9 publications

References 68 publications

Blood monocyte to high density lipoprotein cholesterol ratio (MHR) can be used as an independent risk factor of carotid artery plaque

Blood monocyte to high density lipoprotein cholesterol ratio (MHR) can be used as an independent risk factor of carotid artery plaque

The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

The impact of β‐blockers on the central and delta systolic pressures in a real‐world population with treated hypertension: A cross‐sectional study

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