The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese

Abstract

Background/Aim: Impaired DNA repair capacity may play a critical role in genome instability and carcinogenesis. However, the impact of DNA ligase 1 (Lig1) genotypes on tumorigenesis remains unclear. This study aimed to investigate the contribution of Lig1 rs20579 genotypes to the risk of developing lung cancer, and review the related literature. Materials and Methods: Polymerase chain reactionrestriction fragment length polymorphism analysis was used to determine the genotypes of Lig1 rs20579 and evaluate their association with lung cancer risk among 358 lung cancer cases and 716 age-and sex-matched cancer-free control subjects. Results: The distribution of GG, AG, and AA genotypes for Lig1 rs20579 was 77.1%, 20.8%, and 2.1% among the controls, and 76.0%, 21.5%, and 2.5% among the lung cancer cases (p for trend=0.8686). There was no significant difference in the distribution of AG and AA genotypes between the two groups (p=0.8257 and 0.8098, respectively). Allelic frequency analysis indicated that individuals carrying the variant A allele for Lig1 rs20579 had a non-significant 1.07-fold higher risk of developing lung cancer than those carrying the wild-type G allele [95% confidence interval (CI)=0. 82-1.40, p=0.6639]. Furthermore, no differential distribution of the Lig1 rs20579 genotype was found among non-smokers (p=0.9910) or smokers (p=0.9001). Conclusion: In contrast to Americans, Lig1 rs20579 genotypes do not appear to play a critical role in determining susceptibility to lung cancer among Taiwanese individuals.Lung cancer accounts for more than 11% of all neoplasms and 18% of cancer-related deaths worldwide (1). Over the last few decades, lung cancer has been the most prevalent malignant tumor and the leading cause of cancer fatalities (2). Lung cancer is the top cause of cancer-related deaths in both sexes (3) and a major public health concern due to its high fatality rate (4) and the 5-year survival rate of only 17.8% (5). Globally, there were an estimated 2,206,771 new cases of lung cancer in 2020, accounting for 11.4% of all new cancer diagnoses (6). Furthermore, lung cancer had the third-highest incidence and mortality after breast and prostate 1504

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