The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and<i>Helicobacter Pylori</i>Infection to Gastric Cancer

FU, CHUN-KAI; MONG, MEI-CHIN; TZENG, HUEY-EN; YANG, MEI-DUE; CHEN, JAW-CHYUN; HSIA, TE-CHUN; HSIA, NING-YI; TSAI, CHIA-WEN; CHANG, WEN-SHIN; CHEN, CHOU-PIN; BAU, DA-TIAN

doi:10.21873/invivo.13414

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…RAD51 rs1801320 genotyping procedures. Genomic DNA extracted from peripheral blood leukocytes of both patients and controls was prepared using the QIAamp Blood Mini Kit (Blossom, Taipei, Taiwan, ROC) and processed as previously outlined (63)(64)(65)(66). The polymerase chain reaction (PCR) cycling programs for RAD51 rs1801320 genotypes were as follows: an initial cycle at 94˚C for 5 min; followed by 35 cycles of 94˚C for 30 s, 55˚C for 30 s, and 72˚C for 30 s; and a final extension at 72˚C for 10 min.…”

Section: Methodsmentioning

confidence: 99%

The Contribution of Double-strand Break Repair Radiation Sensitive Protein 51 Genotypes to Lung Cancer in Taiwan

CHIU,

WANG,

et al. 2024

Anticancer Res

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Background/Aim: Numerous studies have reported the over-expression of the radiation-sensitive protein 51 (RAD51) in various types of cancer. However, the role of RAD51 genotypes in lung cancer remains largely unknown. This study aimed to assess the impact of the common variant RAD51 rs1801320 (G-135C) genotypes on the risk of lung cancer in Taiwan. Materials and Methods: The contribution of RAD51 rs1801320 genotypes to lung cancer risk was investigated in a cohort comprising 358 lung cancer patients and 716 age-and sex-matched healthy controls, utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The analysis revealed that among the control subjects, the percentages of GG, CG, and CC genotypes of RAD51 rs1801320 were 73.2%, 24.3%, and 2.5%, respectively. Among the lung cancer patients, these percentages were 71.0%, 25.1%, and 3.9%, respectively (p for trend=0.4075). Allelic frequency distributions showed no significant association between the C allele of RAD51 rs1801320 and lung cancer risk determination (p=0.2987). Specifically, the RAD51 rs1801320 CC genotypes were associated with an elevated risk of lung cancer among males [adjusted odds ratio (aOR)=2.28, 95% confidence interval (95%CI)=1. , but not among females and non-smokers. Conclusion: The RAD51 rs1801320 CC genotype was identified as a risk factor for elevated lung cancer risk in males and smokers. This genotype may serve as a molecular biomarker at the DNA level for early detection and prediction of lung cancer in Taiwan.

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Section: Methodsmentioning

confidence: 99%

The Contribution of Double-strand Break Repair Radiation Sensitive Protein 51 Genotypes to Lung Cancer in Taiwan

CHIU,

WANG,

et al. 2024

Anticancer Res

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Gastric cancer—Epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: An updated review

Mamun,

Younus,

Rahman

2024

Cancer Treatment and Research Communications

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Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer

Watrowski,

Schuster,

Van Gorp

et al. 2024

IJMS

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Single nucleotide polymorphisms (SNPs) of the IL-16 gene have been reported to influence the risk of several cancers, but their role in ovarian cancer (OC) has not been studied. Using the restriction fragment length polymorphism (PCR-RFLP) method, we examined four IL-16 SNPs: rs11556218 (T > G), rs4778889 (T > C), rs4072111 (C > T), and rs1131445 (T > C) in blood samples from 413 women of Central European descent, including 200 OC patients and 213 healthy controls. Among the patients, 62% were postmenopausal, 84.5% were diagnosed in late stages (FIGO IIb-IV), and 73.5% had high-grade serous OC (HGSOC). Minor allele frequencies in controls were 9.2% for rs11556218 (G allele), 13.7% for rs4778889 (C allele), 10.4% for rs4072111 (T allele), and 32.3% for rs1131445 (C allele). We found significant associations of rs11556218 (G vs. T allele: OR 2.76, 95% CI 1.84–4.14, p < 0.0001) with elevated OC risk in the whole cohort (p < 0.001) and in both premenopausal (p < 0.001) and postmenopausal (p = 0.001) subgroups. These associations remained significant across heterozygote (p < 0.001), dominant (p < 0.001), and overdominant (p < 0.001) models. IL-16 rs4778889 was associated with OC risk predominantly in premenopausal women (p < 0.0001 in almost all models). In the whole cohort, the C allele was associated with OC risk (OR 1.54, CI 95% 1.06–2.23, p = 0.024), and the association of rs4778889 was significant in dominant (p = 0.019), overdominant (p = 0.033), and heterozygote (p = 0.027) models. Furthermore, rs4778889 was linked with HGSOC (p = 0.036) and endometriosis-related OC subtypes (p = 0.002). No significant associations were found for rs4072111 or rs1131445 (p = 0.81 or 0.47, respectively). In conclusion, rs11556218 and rs4778889 SNPs are associated with OC risk, especially in premenopausal women.

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The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, andHelicobacter PyloriInfection to Gastric Cancer

Cited by 3 publications

References 43 publications

The Contribution of Double-strand Break Repair Radiation Sensitive Protein 51 Genotypes to Lung Cancer in Taiwan

The Contribution of Double-strand Break Repair Radiation Sensitive Protein 51 Genotypes to Lung Cancer in Taiwan

Gastric cancer—Epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: An updated review

Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer

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