The association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with myocardial infarction risk in Han Chinese

Xia, Kun; Ding, Rongjing; Zhang, Zhiyong; Li, Weiming; Shang, Xiaoming; Yang, Xinchun; Wang, Lefeng; Zhāng, Qí

doi:10.1016/j.gene.2017.04.045

Cited by 12 publications

(5 citation statements)

References 42 publications

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“…Coronary artery disease (CAD) is one of the leading causes of disease in developed and developing countries. The β 1 -adrenergic receptor (ADRB1) and β 2 -adrenergic receptor (ADRB2) play a pivotal role in the regulation of the cardiovascular system (Dhein et al , 2017; Xia et al , 2017). There are two major single nucleotide polymorphisms (SNPs) in the ADRB1 gene: the Ser49Gly (rs1801252) and Arg389Gly (rs1801253) polymorphisms; the ADRB2 gene exhibits three major SNPs: the Arg16Gly (rs1042713), Gln27Glu (rs1042714), and Thr164Ile (rs1800888) polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

β₂-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

Yuan

Sun

et al. 2019

Genetic Testing and Molecular Biomarkers

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Aims: β-Adrenergic receptors (ADRBs) play a pivotal role in cardiovascular disease. Recently, genetic polymorphisms of ADRB1 and ADRB2 have been suggested to be associated with cardiovascular events and all-cause mortality in coronary artery disease (CAD) patients, but the results of relevant studies are inconsistent and controversial. Therefore, we performed a meta-analysis to investigate the association between ADRB1 and ADRB2 polymorphisms with cardiovascular events and all-cause mortality in CAD patients.Materials and Methods: The PubMed, Ovid, EMBASE, Cochrane, and CINAHL databases were searched for eligible studies published before April 2018. A total of 5495 patients from eight studies were included in our meta-analysis.Results: We found that CAD patients harboring the ADRB2 rs1042714 Glu27 allele exhibited a positive association with cardiovascular events (risk ratio [RR] = 1.31, 95% confidence interval [CI]: 1.08–1.58, p = 0.006), but not with all-cause mortality (RR = 0.97, 95% CI: 0.70–1.35, p = 0.859), compared with patients who were Gln27 homozygotes. No other significant associations were observed between ADRB1 (rs1801252, rs1801253), ADRB2 (rs1042713, rs1800888) polymorphisms and cardiovascular events or all-cause mortality in CAD patients.Conclusion: This study suggests that the identified ADRB2 polymorphism could influence the outcomes of CAD patients, showing important clinical value.

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Section: Introductionmentioning

confidence: 99%

β₂-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

Yuan

Sun

et al. 2019

Genetic Testing and Molecular Biomarkers

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“…analyzed 83 Japanese patients with CAD and 107 healthy controls and found that the ADRB3 Trp64Arg variation was significantly correlated with this disease. Further, Xia et al [31]. recently studied Chinese patients with myocardial infarction, including 717 patients with myocardial infarction and 612 healthy controls, and found that the ADRB3 Trp64Arg mutation increased the risk of myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population

Zhang

Zhao

et al. 2020

Preprint

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Background: Coronary artery disease (CAD) is the most common type of heart disease and causes high morbidity worldwide. The β3-adrenergic receptor gene (ADRB3) is potentially linked to obesity, insulin resistance, diabetes, and hypertension based on its role in energy homeostasis and lipolysis in human adipose tissue. However, the relationship between ADRB3 gene polymorphisms and CAD remains unclear. we sought to assess this association in the Han and Uygur populations of China. Methods: We used the following two case-control studies: a Han population (308 CAD patients and 294 control subjects) and an Uygur population (259 CAD patients and 161 control subjects). All 1022 participants were genotyped for the two single nucleotide polymorphisms (SNPs) (rs1892818, rs9693898) of ADRB3 using real-time polymerase chain reaction (TaqMan). Results: We found that the rs1892818 CT genotype (8.5% compared with 3.9%, P = 0.019) and T allele (4.3% compared with 1.9%, P = 0.021) were more frequent in control subjects than in CAD patients of the Han, but not Uygur population. No significant differences in rs9693898 of ADRB3 were found between CAD patients and control subjects for both populations. After adjusting for other confounders, logistic regression analysis suggested that the difference remained significant between the two groups in the Han population (CT compared with CC, P = 0.036, OR = 0.410, 95% CI: 0.178–0.944). Conclusion: Our results suggest that ADRB3 rs1892818 is associated with CAD in a Han population and that the CT genotype of ADRB3 rs1892818 might be a protective factor for CAD in Han individuals.

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“…New findings were available in the last two decades for β-ar signalling. In the classic linear model, β-ars were thought to primarily mediate cardiac functions such as inotropy, chronotropy, and lusitropy through the activation of stimulating Gs pathway, activating the adenylate cyclase which increases cAMP's intracellular concentration (Guimarães and Moura, 2001;Xia et al, 2017). Increased cAMP's concentration leads to the activation of PKA, which phosphorylates several downstream proteins like calcium ATPase enhancing intracellular calcium concentration with a consequent increase of heart contractions and blood flow rate (Bernstein et al, 2011).…”

Section: Relationship Between Localization and Function Of β2-adrenergic Receptors In The Cardiovascular Systemmentioning

confidence: 99%

“…Recent studies reported the correlation of a different expression of β2-ar in the myocardium and heart diseases, potentially allowing to detect new markers of myocardium infarction. Moreover, β2-ar can be a potential therapy target for several heart diseases (Li et al, 2019;Xia et al, 2017). In addition, β2-ars are also present on endothelial cells where they modulate vasodilation and angiogenesis (Chisholm et al, 2012;Guimarães and Moura, 2001).…”

Section: Introductionmentioning

confidence: 99%

The effects of beta (2)-adrenergic receptors activation on the cardiovascular system and on the skeletal muscle: A narrative review

Romano¹,

Cozzolino²,

Zinno³

et al. 2021

Journal of Human Sport and Exercise - 2021 - Winter Conferences of Sports Science

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Beta(2)-adrenergic receptors (adrenoceptors) are activated by the catecholamines norepinephrine and epinephrine. Adrenoceptors are found in different tissues, such as smooth muscle, skeletal muscle and myocardium. Stimulation of adrenoceptors is implicated in several physiological functions in the body, such as bronchodilation, increased perfusion and vasodilation. The latters, together with increased muscular mass and contraction speed, facilitate muscle's motility and contraction. In the cardiovascular system, the activation of adrenoceptors increases heart muscle contraction, cardiac output and heart rate. Some studies also suggested a cardioprotective role of the stimulation of adrenoceptors. Beta(2)-adrenergic receptors agonists, principally divided in long-acting beta(2) agonists (LABAs) and short-acting beta(2) agonists (SABAs), are primarily used to treat asthma and other pulmonary disorders. Beta(2)-adrenergic receptors activation has been correlated with anabolic properties and muscular hypertrophy with the use of oral clenbuterol, as well as intravenous albuterol. Given these anabolic, lipolytic and performance-enhancing effects, LABAs are frequently abused by athletes. For this reason, most of these drugs are banned by the World Anti-Doping Agency, or admissible only with limitations. The aim of this narrative review is to report the results of some recent studies about the effects of beta(2)-adrenergic receptors activation on the cardiovascular system and on the skeletal muscle.

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The association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with myocardial infarction risk in Han Chinese

Cited by 12 publications

References 42 publications

β₂-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

β₂-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population

The effects of beta (2)-adrenergic receptors activation on the cardiovascular system and on the skeletal muscle: A narrative review

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The association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with myocardial infarction risk in Han Chinese

Cited by 12 publications

References 42 publications

β2-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

β2-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population

The effects of beta (2)-adrenergic receptors activation on the cardiovascular system and on the skeletal muscle: A narrative review

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β₂-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

β₂-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies