The association of health-related quality of life and cerebral gray matter volume in the context of aging: A voxel-based morphometry study with a general population sample

Hahm, Stefanie; Lotze, Martín; Domín, Martin; Schmidt, Silke

doi:10.1016/j.neuroimage.2019.02.035

Cited by 18 publications

(12 citation statements)

References 71 publications

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“…This extends a previous finding in middle-aged athletes (Eyme et al, 2019 ) to the older population. In agreement with the well-established aging-related deterioration of the precuneus (Eyme et al, 2019 ; Hahm et al, 2019 ), our findings validate the analogous effects of sports in older athletes (≥65 years). The current results also highlight the benefits of commencing sports training in early life and continuing training into old age to maintain the structural integrity of the precuneus.…”

Section: Discussionsupporting

confidence: 92%

“…Magnetic resonance imaging (MRI) studies have revealed key structural characteristics of the aging brain. For example, the gray matter volume (GMV) of the frontal cortex, cingulate cortex, hippocampus, cerebellum, basal ganglia, and parietal lobe (e.g., supramarginal gyrus and precuneus) decreases with age (Raz et al, 2004 , 2010 ; Ramanoël et al, 2018 ; Eyme et al, 2019 ; Hahm et al, 2019 ). Atrophy of these brain regions is associated with age-related decline in various behavioral measures of cognitive function (Seidler et al, 2010 ; Nyberg et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Early-Commenced and Continued Sports Training on the Precuneus in Older Athletes

Yamashita

Suzuki

Kawagoe

et al. 2021

Front. Hum. Neurosci.

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Intervention studies on sedentary older adults have demonstrated that commencing physical exercise at an older age has a positive effect on brain structure. Although this suggests that older athletes with lifelong sports training have larger gray matter volume (GMV) in some brain regions compared to age-matched non-athletes, evidence in the literature is scarce. Moreover, it remains unclear whether a larger GMV is associated with training intensity or period of training in life. To address these gaps in the literature, we compared regional brain GMV between 24 older athletes (mean age, 71.4 years; age at the commencement of sports training, 31.2 years, continuous sports training, 40.0 years; current training time, 7.9 h/week) and 24 age-matched non-athletes (mean age, 71.0 years). The period of sports training and the current training time of the athletes were assessed. Both groups were evaluated for physical activity intensity as well as cognitive and motor performance. Although no group differences were noted in cognitive and motor performance, athletes reported higher physical activity intensity than non-athletes. Whole-brain structural analysis revealed a significantly larger GMV in several brain regions in athletes. Notably, the GMV of the precuneus in athletes was positively correlated with earlier commencement of sports training and training duration but was negatively correlated with current training time. Our findings demonstrate that early-commenced and continued sports training predicts structural maintenance of the precuneus in old age. Our results also suggest that excessive training time in old age may have a negative impact on the GMV of the precuneus; thereby delineating how the precuneus is associated with lifelong sports training in older athletes.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Impact of Early-Commenced and Continued Sports Training on the Precuneus in Older Athletes

Yamashita

Suzuki

Kawagoe

et al. 2021

Front. Hum. Neurosci.

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“…Some of these findings have been obtained in large samples of different research groups and seem to be quite robust. The absence of these factors increase quality of life (Hahm et al [ 113 ]), participants show higher income (Lotze et al [ 58 ]), and are more active in leisure sports (Eyme et al [ 45 ]) and therefore show opposite effects on the brain’s GMV (increase in medial prefrontal GMV with higher quality of life; increase in hippocampus/amygdala GMV with higher income and less stress). In addition, all factors on the brain are dependent in their effect on brain maturation, which has to be investigated in other cohorts including younger participants.…”

Section: Resultsmentioning

confidence: 99%

SHIP-MR and Radiology: 12 Years of Whole-Body Magnetic Resonance Imaging in a Single Center

et al. 2021

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The Study of Health in Pomerania (SHIP), a population-based study from a rural state in northeastern Germany with a relatively poor life expectancy, supplemented its comprehensive examination program in 2008 with whole-body MR imaging at 1.5 T (SHIP-MR). We reviewed more than 100 publications that used the SHIP-MR data and analyzed which sequences already produced fruitful scientific outputs and which manuscripts have been referenced frequently. Upon reviewing the publications about imaging sequences, those that used T1-weighted structured imaging of the brain and a gradient-echo sequence for R2* mapping obtained the highest scientific output; regarding specific body parts examined, most scientific publications focused on MR sequences involving the brain and the (upper) abdomen. We conclude that population-based MR imaging in cohort studies should define more precise goals when allocating imaging time. In addition, quality control measures might include recording the number and impact of published work, preferably on a bi-annual basis and starting 2 years after initiation of the study. Structured teaching courses may enhance the desired output in areas that appear underrepresented.

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“…Taking more time to understand can be costly in conversation, when a listener could fall behind or lose the thread - common complaints for older adults, especially with hearing loss. Cingulo-opercular regions exhibit structural declines with increasing age and poor health ( Eckert et al, 2010 ; Fjell et al, 2009 ; Hahm et al, 2019 ) and less adaptive control is observed with increasing age ( Vaden et al, 2015 ). More research is needed to determine the extent to which decision criteria flexibility, and perceptual decisionmaking more broadly, change with increasing age and have detrimental consequences for the ability to adapt to changing listening conditions.…”

Section: Discussionmentioning

confidence: 99%

Evidence for cortical adjustments to perceptual decision criteria during word recognition in noise

et al. 2022

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The association of health-related quality of life and cerebral gray matter volume in the context of aging: A voxel-based morphometry study with a general population sample

Cited by 18 publications

References 71 publications

Impact of Early-Commenced and Continued Sports Training on the Precuneus in Older Athletes

Impact of Early-Commenced and Continued Sports Training on the Precuneus in Older Athletes

SHIP-MR and Radiology: 12 Years of Whole-Body Magnetic Resonance Imaging in a Single Center

Evidence for cortical adjustments to perceptual decision criteria during word recognition in noise

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