The Association of HLA and Immune Responses to Bovine Collagen Implants

Vanderveen, Evelyn E.; McCoy, J. Philip; Schade, William J.; Kapur, Janet J.; Hamilton, Ted A.; Ragsdale, Carol Godoshian; Grekin, Roy C.; Swanson, Neil A.

doi:10.1001/archderm.1986.01660180056014

Cited by 16 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allergic reactions generally occur within minutes of exposure, but delayed hypersensitivity can occur several months or years after injection [ 9 ]. Allergy to bovine derived collagen is genetically regulated by the lack of the HLA-DR4 antigen [ 234 ]. To avoid allergic reaction, skin testing now is mandatory.…”

Section: Adverse Reactions To Collagen-based Injectable Implantsmentioning

confidence: 99%

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Salvatore¹,

Natali

Brunetti³

et al. 2023

Polymers

View full text Add to dashboard Cite

Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly and sometimes constant interventions. With the average lifetime increase, a proportional increase of age-related soft tissues diseases has been witnessed. Due to this, the last two decades have seen a tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific and industrial research has led to the recognition of injectable formulations as a new advantageous approach in the management of complex diseases that are challenging to treat with conventional strategies. Among them, collagen-based products are revealed to be one of the most promising among bioactive biomaterials-based formulations. Collagen is the most abundant structural protein of vertebrate connective tissues and, because of its structural and non-structural role, is one of the most widely used multifunctional biomaterials in the health-related sectors, including medical care and cosmetics. Indeed, collagen-based formulations are historically considered as the “gold standard” and from 1981 have been paving the way for the development of a new generation of fillers. A huge number of collagen-based injectable products have been approved worldwide for clinical use and have routinely been introduced in many clinical settings for both aesthetic and regenerative surgery. In this context, this review article aims to be an update on the clinical outcomes of approved collagen-based injectables for both aesthetic and regenerative medicine of the last 20 years with an in-depth focus on their safety and effectiveness for the treatment of diseases of the integumental, gastrointestinal, musculoskeletal, and urogenital apparatus.

show abstract

Section: Adverse Reactions To Collagen-based Injectable Implantsmentioning

confidence: 99%

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Salvatore¹,

Natali

Brunetti³

et al. 2023

Polymers

View full text Add to dashboard Cite

show abstract

Adverse reactions to bovine collagen implants. Additional evidence for immune response gene control of collagen reactivity in humans

Trentham¹

1986

Archives of Dermatology

View full text Add to dashboard Cite

Immune response after collagen injection for laryngeal rehabilitation: development of an enzyme-linked immunosorbent assay

Remacle¹

1991

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The appearance of circulating antibodies directed against bovine collagen has been observed in dermatology after collagen injections with or without clinical reactions. Knowing the serologically positive patients among the clinically negatives ones is important if a second collagen injection should be planned. In these cases, skin and blood tests have to be carefully checked to confirm reactivity. In connection with this, we have developed an enzyme-linked immunosorbent assay (ELISA) for determining the response to GAX collagen injections. Such injections induce a very low rate of anti-collagen antibodies. However, without having recourse to a positive control permitting statistical analysis of data, no conclusions can be made about significant positivity. In the present investigation of 12 patients following GAX collagen injections into the larynx, 1 was found to be borderline and 1 positive (17%). The positive control was made up with 20 ng/ml anti-type III collagen antibodies, which was purified and tested against type III bovine and human collagen. The present study showed that the systematic detection of antinuclear or anti-DNA antibodies after GAX collagen injection is not useful. However, the anti-collagen positivity of two control samples from 3 patients already positive for antinuclear antibodies demonstrates that bovine collagen injections are contraindicated in auto-immune disease.

show abstract

The Association of HLA and Immune Responses to Bovine Collagen Implants

Cited by 16 publications

References 12 publications

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Adverse reactions to bovine collagen implants. Additional evidence for immune response gene control of collagen reactivity in humans

Immune response after collagen injection for laryngeal rehabilitation: development of an enzyme-linked immunosorbent assay

Contact Info

Product

Resources

About